Funding and Publications

Undergraduate student authors in the Wu Lab are underlined

Lowran, K.A., Campbell, L., Cismas, E., and Wu, C.G. (2025) Domain-specific DNA binding activities of BRCA1 reveal substrate preferences for homologous recombination and telomere regulation. Biochemistry (accepted; also in bioRxiv). 

Campbell, L., Lowran, K.A., Cismas, E., and Wu, C.G. (2025) 8-Oxoguanine Disrupts G-Quadruplex DNA Stability and Modulates FANCJ AKKQ Peptide Binding. Molecules (in press; also in bioRxiv)

Tabobondung, M., Connelly, C., Esposto, J., Ebralidze, I., Wu, C.G., Martic, S. (2025) Electrochemical and surface analysis of interactions between Cu(II) and Zn(II) metal ions with TDP-43 protein immobilized on gold surface. Canadian Journal of Chemistry (in review). 

Ketkar, A., Sewilam, R., Paxton, B., Morales, M., Schaller, J., Jackson, K., Lowran, K., Paul, A., Patel, M., Seenivasan, S., McCrury, M., Maddukuri, L., Kendrick, S., Wu, C.G., Gunderson, J., Eoff, R.L. (2025) Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA. Nucleic Acids Research (submitted).

Cismas, E., Salib, V., Lowry, E., and Wu, C.G. (2025) Pathogenic BRCA1 DBD variants exhibit altered DNA binding specificities and susceptibility to menadione. (in preparation)

Lowran, K., Salib, V., Cismas, C., and Wu, C.G. (2024) Advancing the Study of Protein-G4 Interactions in DNA Repair: Insights from Biolayer Interferometry. Methods in Enzymology 695, 89-101

Medley, J., Yim, N., DiPanni, J., Sebou, B., Shaffou, B., Cramer, E., Wu, C.G., Kabara, M., and Song, M.H. (2023) Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number. iScience 26(12), 108410 

Ahmad, M., Esposto, J., Golec, C., Wu, C.G., and Martic, S. (2021) Aggregation of gelsolin wild-type and G167K/R, N184K, and D187N/Y mutant peptides and inhibition. Molecular and Cellular Biochemistry 476(6) ,2393-2408

 Ziu, I., Rettig, I., Luo, D., Dutta, A., McCormick, T., Wu, C.G., and Martic, S. (2020) The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorganic and Medicinal Chemistry 28(18) 115667

Lowran, K., Campbell, L., Popp, P., and Wu, C.G. (2019) Assembly of a G-quadruplex repair complex by the FANCJ DNA helicase and the REV1 polymerase. Genes  11(1), 5-21

Ziu, I., Laryea, E., Alashkar, F., Wu, C.G., and Martic, S. (2019) A dip-and-read optical aptasensor for detection of tau protein. Analytical and Bioanalytical Chemistry 412(5), 1193-1201

Wu, C.G., and Spies, M. (2016) G-quadruplex recognition and remodeling by the FANCJ helicase. Nucleic Acids Res 44(18), 8742-8753

*Bain, F., *Wu, C.G., Spies, M. (2016) Single-molecule sorting of DNA helicases. Methods 108, 14-23 (*these authors contributed equally)

Xie, F., Wu, C.G., Weiland, E., Lohman, T.M. (2013) Asymmetric Regulation of Bipolar Single-stranded DNA Translocation by the Two Motors within E. coli RecBCD Helicase. JBC 288(2), 1055-1064

Wu, C.G., and Spies, M. (2012) Overview: What are Helicases? Adv Exp Med Biol 767, 1-16

Wu, C.G., Xie, F., Lohman, T.M. (2012) The Primary and Secondary Translocase Activities within E. coli RecBC Helicase are Tightly Coupled to ATP Hydrolysis by the RecB Motor. J Mol Biol 423(3), 303-314

Fischer, C.J., Tomko, E.J., Wu, C.G., and Lohman, T.M. (2012) Fluorescence Methods to Study DNA Translocation and Unwinding Kinetics by Nucleic Acid Motors. Methods Mol Biol 875, 85-104

Pugh, R.A., Wu, C.G., and Spies, M. (2011) Regulation of Translocation Polarity by Helicase Domain 1 in SF2B Helicases. EMBO J 31(2), 503-514

Wu, C.G., Bradford, C.L., Lohman, T.M. (2010) E. coli RecBC Helicase has Two Translocase Activities Controlled by a Single ATPase Motor. Nat Struc Mol Biol 17(10), 1210-1217

Lohman, T.M., Tomko, E.J., Wu, C.G. (2008) Non-hexameric DNA Helicases and Translocases: Mechanisms and Regulation. Nat Rev Mol Cell Biol 9(5), 391-401

Wu, C.G. and Lohman, T.M. (2008) Influence of DNA End Structure on the Mechanism of Initiation of DNA Unwinding by the Escherichia coli RecBCD and RecBC Helicases. J Mol Biol 382(2), 312-326