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Aerobic and resistance exercise are the cornerstones of managing diabetes and reducing complications, however, there is limited evidence explaining why exercise works in some cases but not others. Mechanistic clinical trials, which assess whether and how an exercise intervention works, are urgently needed. To address this critical gap, we have successfully completed the following trials:
Reversing diabetic neuropathy with exercise
Reversing diabetic neuropathy with exercise
This was the first clinical trial first to examine exercise induced adaptations in nerve and muscle non-invasively using co-localized advanced MRI in people with diabetic neuropathy.
Pain Mechanisms and Muscle activation with BFR Resistance Training
Pain Mechanisms and Muscle activation with BFR Resistance Training
Our findings suggest that resistance exercise affords a reduction in pain sensitivity, and that muscle activation may contribute to the reduction in pain sensitivity.
Wearable muscle vibration and resistance training
Wearable muscle vibration and resistance training
We found that local muscle vibration can reduce delayed onset muscle soreness accompanying resistance training.
Targeting hyaluronan accumulation with exercise
Targeting hyaluronan accumulation with exercise
This clinical trial was funded by the Inaugural Georgeny Award from the Foundation of Physical Therapy Research to examine the effects of exercise on muscle stiffness and hyaluronan accumulation in people with diabetes.
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