Publications

2023

Raseley K, Jinwala Z, Zhang D, Xiao M. Single-Molecule Telomere Assay via Optical Mapping (SMTA-OM) Can Potentially Define the ALT Positivity of Cancer. 2023 June 16; 14(6): 1278. DIO: 10.3390/genes14061278.

RagupathiA A, Singh M, Perez AM, Zhang D. Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights. Front. Cell Dev. Biol.  2023 March 22; 11: 1133472. DIO 10.3389//fcell.2023.1133472. 

Batista NJ, Desai SG, Perez AM, Finkelstein A, Radigan R, Singh M, Landman A, Drittel B, Abramov D, Ashan M, Cornwell S, Zhang D. The molecular and cellular basis of Hutchinson-Gildord progeria syndrome and potential treatments. Genes. 2023 Feb. 27; 14(3): 602. DIO: 10.3390/genes14030602.

2022

Loomba K, Shi D, Sherpa T, Chen J, Daniels TJ, Pavia CH, Zhang D. Use of the Western blot technique to identify the immunogenic proteins of Borrelia burgdorferi for developing a Lyme disease vaccine. Journ Biomed Pharm. 2022 Nov. 18; 157: 114013. DIO: 10.1016/j.biopha.2022.114013. 

Singh M, Zhang S, Perez AM, Lee EYC, Lee MYWT, Zhang D. POLDIP3: At the Crossroad of RNA and DNA Metabolism. Genes. 2022 Oct 22; 13(11), 1921. DIO: 10.3390/genes13111921. 

Singh M, MacKenzie D, Desai S, Batista N, Zhang D.  Diagnostic Biomarkers and Therapeutic Targets of ALT-Positive Cancers. Prec Med. 2022 Oct 14; 9(5). 

Zhang S, Lee WYC, Lee MYWT, Zhang D. POLDIP3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress. Anim Mosels Exp Med. 2022 Sept 27: 00 (1-9). DOI: 10.1002/ame2.12274 

2021

MacKenzie D, Watter AK, To JT, Young MW, Muratori J, Wilkoff MH, Abraham RG, Plummer M,  Zhang D. ALT Positivity in Human Cancers: Prevalence and Clinical Insights. Cancers (Basel). 2021 May 14;13(10). doi: 10.3390/cancers13102384. Review. PubMed PMID:  34069193; PubMed Central PMCID: PMC8156225.

2020

Seltzer ES, Watters AK, MacKenzie D Jr, Granat LM, Zhang D. Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Cancers (Basel). 2020 Oct 30;12(11). doi: 10.3390/cancers12113203. Review. PubMed PMID: 33143283; PubMed Central PMCID: PMC7693730.

Watters AK, Seltzer ES, MacKenzie D Jr, Young M, Muratori J, Hussein R, Sodoma AM, To J, Singh M,  Zhang D. The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers. Genes (Basel). 2020 Jul 21;11(7). doi: 10.3390/genes11070829. Review. PubMed PMID: 32708251; PubMed Central PMCID: PMC7396976.

Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, Huang J, Mohan N, Klosek S, Parsa K, Guh CY, Lu R, Pickett HA, Chu HP,  Zhang D. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019 Dec 13;9(1):19110. doi: 10.1038/s41598-019-55537-5. PubMed PMID: 31836759; PubMed Central PMCID: PMC6911001

2019

Granat LM, Kambhampati O, Klosek S, Niedzwecki B, Parsa K,  Zhang D. The promises and challenges of patient-derived tumor organoids in drug development and precision oncology. Animal Model Exp Med. 2019 Sep;2(3):150-161. doi: 10.1002/ame2.12077. eCollection 2019 Sep. Review. PubMed PMID: 31773090; PubMed Central PMCID: PMC6762043.

2018

Guo B, Han X, Tkach D, Huang SG,  Zhang D. AMPK promotes the survival of colorectal cancer stem cells. Animal Model Exp Med. 2018 Jun;1(2):134-142. DOI: 10.1002/ame2.12016. eCollection 2018 Jun. PubMed PMID: 30891558; PubMed Central PMCID: PMC6388072.

2017

Pan X, Ahmed N, Kong J,  Zhang D. Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy. Mol Cell Oncol. 2017;4(6):e1360978. DOI: 10.1080/23723556.2017.1360978. eCollection 2017. PubMed PMID: 29209649; PubMed Central PMCID: PMC5706943.

Pan X, Drosopoulos WC, Sethi L, Madireddy A, Schildkraut CL,  Zhang D. FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5940-E5949. DOI: 10.1073/pnas.1708065114. Epub 2017 Jul 3. PubMed PMID: 28673972; PubMed Central PMCID: PMC5530707.

2015 and Earlier 

Abdullah A, Sane S, Branick KA, Freeling JL, Wang H,  Zhang D, Rezvani K. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15;6(27):23561-81. DOI: 10.18632/oncotarget.4452. PubMed PMID: 26188124; PubMed Central PMCID: PMC4695137.

Abdullah A, Sane S, Freeling JL, Wang H, Zhang D, Rezvani K. Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells. J Cancer. 2015;6(11):1066-78. DOI: 10.7150/jca.12134. eCollection 2015. PubMed PMID: 26516353; PubMed Central PMCID: PMC4615341.

Liu Y, Xue Y, Ridley S,  Zhang D, Rezvani K, Fu XD, Wang H. Direct reprogramming of Huntington's disease patient fibroblasts into neuron-like cells leads to abnormal neurite outgrowth, increased cell death, and aggregate formation. PLoS One. 2014;9(10):e109621. DOI: 10.1371/journal.pone.0109621. eCollection 2014. PubMed PMID: 25275533; PubMed Central PMCID: PMC4183653.

Liu Y, Hettinger CL,  Zhang D, Rezvani K, Wang X, Wang H. Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease. J Neurochem. 2014 May;129(3):539-47. DOI: 10.1111/jnc.12647. Epub 2014 Jan 18. PubMed PMID: 24383989; PubMed Central PMCID: PMC3997618.

Liu Y, Hettinger CL,  Zhang D, Rezvani K, Wang X, Wang H. The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model. Cell Mol Neurobiol. 2014 Apr;34(3):315-22. DOI: 10.1007/s10571-013-0022-9. Epub 2013 Dec 21. PubMed PMID: 24363091; PubMed Central PMCID: PMC3954921.

Sane S, Abdullah A, Boudreau DA, Autenried RK, Gupta BK, Wang X, Wang H, Schlenker EH,  Zhang D, Telleria C, Huang L, Chauhan SC, Rezvani K. Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. Cell Death Dis. 2014 Mar 13;5:e1118. DOI: 10.1038/cddis.2014.100. PubMed PMID: 24625977; PubMed Central PMCID: PMC3973214.

Liu Y, Lü L, Hettinger CL, Dong G,  Zhang D, Rezvani K, Wang X, Wang H. Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice. J Neurosci. 2014 Feb 19;34(8):2813-21. DOI: 10.1523/JNEUROSCI.3541-13.2014. PubMed PMID: 24553923; PubMed Central PMCID: PMC3953589.

Zou J, Zhang D, Qin G, Chen X, Wang H,  Zhang D. BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Cell Cycle. 2014;13(23):3685-97. DOI: 10.4161/15384101.2014.964973. PubMed PMID: 25483079; PubMed Central PMCID: PMC4612125.

Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE,  Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13558-63. DOI: 10.1073/pnas.1306534110. Epub 2013 Jul 30. PubMed PMID: 23901102; PubMed Central PMCID: PMC3746927.

Zou J, Tian F, Li J, Pickner W, Long M, Rezvani K, Wang H,  Zhang D. FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Biol Open. 2013;2(10):1022-31. DOI: 10.1242/bio.20135801. eCollection 2013. PubMed PMID: 24167712; PubMed Central PMCID: PMC3798185.

Zou J, Rezvani K, Wang H, Lee KS,  Zhang D. BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress. Cell Cycle. 2013 Jul 15;12(14):2255-65. DOI: 10.4161/cc.25349. PubMed PMID: 24067368; PubMed Central PMCID: PMC3755076.

Dong G, Gross K, Qiao F, Ferguson J, Callegari EA, Rezvani K,  Zhang D, Gloeckner CJ, Ueffing M, Wang H. Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity. J Neurochem. 2012 Nov;123(3):437-46. DOI: 10.1111/j.1471-4159.2012.07919.x. Epub 2012 Sep 10. PubMed PMID: 22891683.

Dong G, Ferguson JM, Duling AJ, Nicholas RG,  Zhang D, Rezvani K, Fang S, Monteiro MJ, Li S, Li XJ, Wang H. Modeling pathogenesis of Huntington's disease with inducible neuroprogenitor cells. Cell Mol Neurobiol. 2011 Jul;31(5):737-47. DOI: 10.1007/s10571-011-9679-0. Epub 2011 Mar 31. PubMed PMID: 21452052; PubMed Central PMCID: PMC3724999.

Popov N, Wanzel M, Madiredjo M,  Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M. The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 2007 Jul;9(7):765-74. DOI: 10.1038/ncb1601. Epub 2007 Jun 10. PubMed PMID: 17558397.

Wang B, Matsuoka S, Ballif BA,  Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25;316(5828):1194-8. DOI: 10.1126/science.1139476. PubMed PMID: 17525340; PubMed Central PMCID: PMC3573690.

 Zhang D, Zaugg K, Mak TW, Elledge SJ. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell. 2006 Aug 11;126(3):529-42. DOI: 10.1016/j.cell.2006.06.039. PubMed PMID: 16901786.

 Zhang D, Abovich N, Rosbash M. A biochemical function for the Sm complex. Mol Cell. 2001 Feb;7(2):319-29. DOI: 10.1016/s1097-2765(01)00180-0. PubMed PMID: 11239461.

 Zhang D, Rosbash M. Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev. 1999 Mar 1;13(5):581-92. DOI: 10.1101/gad.13.5.581. PubMed PMID: 10072386; PubMed Central PMCID: PMC316503.

Stutz F, Kantor J, Zhang D, McCarthy T, Neville M, Rosbash M. The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region. Genes Dev. 1997 Nov 1;11(21):2857-68. DOI: 10.1101/gad.11.21.2857. PubMed PMID: 9353255; PubMed Central PMCID: PMC316647.