研究成果 Research Awards

References

Selected publications

1.          CL Chiang, SS A Chen, SJ Lee, KC Tsao, PL Chu, CL Yao, and H Lee, “LPA Induces Erythropoiesis through Activating LPA Receptor 3,” Stem Cells. 2011 Sep 13. (SCI: 7.87)

2.          CL Chiang, S Goswami, FW Frissora, Z Xie, PS Yan, R Bundschuh, LA Walker, Xiaomeng Huang, Rajeswaran Mani, XM Mo, S Baskar, C Rader, MA Phelps, G Marcucci, JC Byrd, LJ Lee, N Muthusamy, “ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in CLL mouse model. “Blood. 2019 Aug 1;134(5):432-444. (SCI: 25.66)

3.            CL Chiang, MH Cheng, CH Lin. “From nanoparticles to cancer nanomedicine: old problems with new solutions. “Nanomaterials. 2021 11 (7), 1727. (SCI: 5.35)

4.            CL Chiang, EY Hu, L Chang, J Labanowska, K Zapolnik, X Mo, J Shi, TJ Doong, A Lozanski, PS Yan, R Bundschuh, LA Walker, D Gallego-Perez, W Lu, M Long, S Kim, NA Heerema, G Lozanski, JA Woyach, JC Byrd, LJ Lee, N Muthusamy. “Leukemia-initiating HSCs in chronic lymphocytic leukemia reveal clonal leukemogenesis and differential drug sensitivity,” Cell Reports.  2022 Jul 19;40(3):111115. (SCI: 10.00)

5.            CL Chiang, Y Ma,  YC Hou, Sinyu Chen, MH Chien, ZX Zhang, WH Hsu, X Wang, J Zhang, H Li, L Sun, PS Yan, S Fallen, I Lee, XY Chen, YS Chu, C Zhang, TS Cheng, E Reategui, W Lu, R Lee, Y Yuan, HC Liu, Kai Wang, Michael Hsiao, CY Huang, YS Shan, AS Lee and LJ Lee. “Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer.” Nature Communication. 14 (1), 6692. (SCI:16.6).

6.            Hong Li, CL Chiang (co-first author*), et al., Chi-Ying F. Huang, Cheng-Hsu Wang, Yan-Shen Shan, Chung-Pin Li, Martin Fleisher and L. James Lee, “Exosomal mRNA and microvesicular protein of Glypican 1 in pancreatic cancer diagnosis,” Advanced Science. (IF=17.5).

7.            Yifan Ma, Lili Sun, Jingjing Zhang, CL Chiang, et al., Yuan Yuan and L. James Lee, “Exosomal mRNAs for angiogenic–osteogenic coupled bone repair,” Advanced Science, 2302622 (SCI: 17.5)

8.            S Goswami, CL Chiang, K Zapolnik, J Nunes, A Ventura, X Mo, Z Xie, LJ Lee, S Baskar, C Rader, JC Byrd, M Phelps, B Bhatnagar, N Muthusamy. “ROR1 targeted immunoliposomal delivery of OSU-2S shows selective cytotoxicity in t (1; 19)(q23; p13) translocated B-cell acute lymphoblastic leukemia,” Leukemia research 118, 106872 2022. (SCI: 3.71)

9.            J Pan, CL Chiang, X Wang, P Bertani, Yifan Ma, J Cheng, V Talesara , LJ Lee , W Lu. “Cell membrane damage and cargo delivery in nano-electroporation,” Nanoscale. 2023 Feb 23;15(8):4080-4089. doi: 10.1039/d2nr05575a. “Cell membrane damage and cargo delivery in nano-electroporation,” Nanoscale. 2023 Feb 23;15(8):4080-4089. doi: 10.1039/d2nr05575a. (SCI: 8.31)

10.         S Goswami, R Mani, J Nunes, CL Chiang, K Zapolnik, E Hu, F Frissora, XMo, LA Walker, PYan, R Bundschuh, L Beaver, R Devine, YT Tsai, A Ventura, Z Xie, M Chen, R Lapalombella, A Walker, A Mims, K Larkin, N Grieselhuber, C Bennett, M Phelps, E Hertlein, G Behbehani, S Vasu, JC Byrd, N Muthusamy. “PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia,” Blood. 2022. 139 (9), 1340-1358. (SCI: 25.66)

11.         EY Hu, P Do, S Goswami, J Nunes, CL Chiang, S Elgamal, AM Ventura, C Cheney, K Zapolnik, E Williams, R Mani, F Frissora, X Mo, L Waldmeier, RR Beerli, H Peng, C Rader, M Long, U Grawunder, JC Byrd, N Muthusamy. “The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia.” Blood advances 5 (16), 3152-3162. 2021. (SCI: 6.80)

12.         EY Hu, JS Blachly, C Saygin, HG Ozer, SE Workman, A Lozanski, TJ Doong, CL Chiang, S Bhat, KA Rogers, JA Woyach, KR Coombes, D Jones, N Muthusamy, G Lozanski, JC Byrd “LC-FACSeq is a method for detecting rare clones in leukemia.” JCI insight 5 (12) 2020 (SCI: 6.20)

13.   S Goswami, CL Chiang, K Zapolnik, Z Xie, JL Lee, S Baskar, C Rader, JC Byrd, MA Phelps, B Bhatnagar, N Muthusamy. “ROR1 Targeted Immunoliposomal Delivery of OSU-2S Show Selective Cytotoxicity in t(1;19) Translocated B-ALL.” Blood, The Journal of the American Society of Hematology 134. 2019.

14.   Z Yang, J Shi, J Xie, Y Wang, J Sun, T Liu, Y Zhao, X Zhao, X Wang, Y Ma, V Malkoc, CL Chiang, W Deng, Y Chen, Y Fu, KJ Kwak, Y Fan, C Kang, CC Yin, J Rhee, P Bertani, J Otero, W Lu, K Yun, AS Lee, W Jiang, L Teng, BYS Kim, LJ Lee. “Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.” Nature Biomedical Engineering 4 (1), 69-83.  (SCI: 18.95)

15.       LC Hsiung, CL Chiang, CH Wang, YH Huang, CT Kuo, JY Cheng, CH Lin, V Wu, HY Chou, DS Jong, H Lee, and A M. Wo, “Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments,” Lab on a Chip. 2011; 21;11(14):2333-42. (SCI: 6.26)

16.   CT Kuo, CL Chiang, R YJ Huang, H Lee and A M Wo, “Configurable 2D and 3D spheroid tissue cultures on bioengineered surfaces with acquisition of epithelial–mesenchymal transition characteristics,” NPG Asia Materials. 2012; 4, e27; doi:10.1038 /am.2012.50. (SCI: 9.04)

17.   CT Kuo, CL Chiang, CH Chang, HK Liu, GS Huang, R YJ Huang, H Lee, CS Huang, A M. Wo “Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics,” Biomaterials, 2014, 1562–1571. (SCI: 7.60)

18.   R Mani, Y Mao, F Frissora, CL Chiang, J Wang, Y Zhao, Y Wu, B Yu , R Yan, X Mo, L Yu, J Flynn, J Jones, L Andritsos, S Baskar, C Rader, M Phelps, CS Chen, R Lee, J C. Byrd, LJ Lee. “Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia,” Leukemia, 2014. (SCI: 10.16)

19.   Y You, Y Tian, Z Yang, J Shi, KJ Kwak, Y Tong, A P Estania, J Cao, WH Hsu, Y Liu, CL Chiang, BR Schrank, K Huntoon, DY Lee, Ziwei Li, Y Zhao, H Zhang, TD Gallup, JH Ha, S Dong, Xuefeng Li, Y Wang, WJ Lu, E Bahrani, LJ Lee, L Teng, W Jiang, F Lan, BYS Kim, AS Lee. “Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy,” Nature Biomedical Engineering. 2023 Jan 12. doi: 10.1038/s41551-022-00989-w.  (SCI: 18.95)

20.   LTH Nguyen, J Zhang, XY Rima, X Wang, KJ Kwak, T Okimoto, J Amann, MJ Yoon, T Shukuya, CL Chiang, N Walters, Y Ma, D Belcher, H Li, AF Palmer, DP Carbone, LJ Lee, E Reátegui. “An immunogold single extracellular vesicular RNA and protein (AuSERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients,” J Extracellular Vesicles. 2022 Sep;11(9):e12258.   (SCI: 17.33)

21.   XY Rima, J Zhang, LTH Nguyen, A Rajasuriyar, MJ Yoon, CL Chiang, N Walters, KJ Kwak, LJ Lee, Eduardo Reátegui. “Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis,” Lab on a Chip 2022 (13), 2502-2518 (SCI: 7.51)

22.         Yi You, Y Tian, Z Yang, J Shi , KJ Kwak , Y Tong, AP Estania , J Cao, WH Hsu, Y Liu, CL Chiang, B Shrank, K Huntoon, D Lee, Z Li, Y Zhao, H Zhang, T Gallup, J Ha, S Dong , X Li, Y Wang, WJ Lu, E Bahrani, LJ Lee, L Teng , Wen J, Feng Len, BYS. Kim and Andrew S. Lee, “Intradermally delivered mRNAencapsulating extracellular vesicles for collagen-replacement therapy” Nature Biomedical Engineering (SCI: 29.2), https://doi.org/10.1038/s41551-022-00989-w (2023).