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Can CD4⁺ cytotoxic T cells kill as effectively as CD8⁺ cytotoxic T cells?
Our study provides clear experimental evidence that they can.
Published in @ScienceAdvances, the study shows in humans that CD4-CTLs are as potent killers as CD8-CTLs. Using an integrated multi-omics approach, the team identifies a rare stem cell memory CD4-CTL subset (TSCM-CTLs)—pre-committed to the cytotoxic lineage and potentially crucial for resolving viral infections.
Importantly, the researchers also establish an in vitro differentiation model to generate durable, long-lived, functional CD4-CTLs, opening exciting avenues for immunotherapies, cell-based therapies, vaccine development, and precision medicine.
This work strongly advocates exploring both CD4-CTLs and CD8-CTLs in next-generation vaccines and immunotherapies.
Read the study: https://www.science.org/doi/10.1126/sciadv.ady6423
Nature India covers our story. https://www.nature.com/articles/d44151-026-00015-x
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