Feasibility

Specialty: Breast

PI: Dr Martin Hogg

CPMS No: 55251

Estimated Opening: September / October 2025

Description: A proof of concept study to evaluate treatments’ efficacy by monitoring Minimal Residual Disease using ctDNA in HR-positive/HER2-negative early breast cancer population. -The MiRaDor study-

Specialty: Gynae

PI: Rachel Rigby

IRAS No: 331369

Estimated Opening: Unknown 2025

Description: Gynaecological RAdiotherapy Consent Enhancement

Specialty: Gynae

PI: Prof. Dennis Hadjiyiannakis

CPMS No: 368839

Estimated Opening: December 2025

Description: A Phase 3, Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)

Specialty: Lung

PI: Dr Amin Ali

CPMS No: 64727

Estimated Opening: September / October 2025

Description: Safety and effectiveness of BNT327, an investigational therapy in combination with chemotherapy for patients with untreated small-cell lung cancer

Speciality: Prostate

PI: Mr Michal Smolski

CPMS No: 63289

Estimated Opening: TBC 2025

Description: A randomised controlled trial comparing the clinical and cost-effectiveness of lymph node removal in patients undergoing curative surgery for localised high-risk Prostate Cancer.

Specialty: Radiotherapy

PI: Mr Luigi Volpini

IRAS No: 325882

Estimated Opening: July / August 2025

Description: A phase III trial of proton beam therapy versus intensity-modulated radiotherapy for the treatment of sinonasal malignancy