Providing excellence in clinical research delivery
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The National Institute for Health and Care Research (NIHR) Sheffield Clinical Research Facility (CRF) is part of the NIHR and hosted by Sheffield Teaching Hospitals NHS Foundation Trust in partnership with the University of Sheffield.
The NIHR funds, enables and delivers world-leading health and social care research that improves people’s health and wellbeing and promotes economic growth.
NIHR Clinical Research Facilities (CRFs) are purpose-built facilities in NHS hospitals where researchers can conduct studies. The NIHR has awarded £161 million over 5 years to 28 CRF facilities across England, to support early-phase and complex studies.
In 2022, the NIHR Sheffield CRF was awarded £7.9m in funding which will support the development and testing of new treatments for diseases, many of which currently have no cure. This funding award covers 2022 to 2029.
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World-first trial harnesses remote technology to help motor neuron disease patients live longer
World-first trial harnesses remote technology to help motor neuron disease patients live longer
A world-first clinical trial supporting people living with motor neuron disease (MND) to access breathing support from home using remote monitoring tech is being launched by Sheffield Teaching Hospitals NHS Foundation Trust in partnership with the University of Sheffield.
MND is an incurable and rapidly progressing muscle-wasting illness – with breathing difficulties common as the muscles that help the lung inhale and exhale weaken. Many people with MND will rely on ventilation support. This type of ventilation needs regular monitoring and timely intervention to prevent complications and maintain a better quality of life. However, over half of people with MND struggle or are unable to use portable ventilators for breathing support for long enough to gain the full benefits.
The £1.7m National Institute for Health and Care Research (NIHR) DENIM trial is testing the benefits of remotely monitoring and adjusting portable ventilators for breathing support in MND patients, across 12 areas of England.
For more information please visit the news page on the Sheffield Teaching Hospitals website.
(November 2025)
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