Inspired by the 2022 Bloomsbury Festival theme of ‘breathe’, the NIHR Moorfields Biomedical Research Centre took part in the Discovery Hub science fair from 20 to 22 October at Senate House in Bloomsbury. We highlighted the links between air pollution and eye disease, alongside science and creative teams from across UCL and further afield.
Our ‘Size up the particles’ activity explored the relative sizes of small particles and how harmful particulate matter (PM), in particular PM10 and microscopic PM2.5 (fine particulate matter), can enter the body.
In 2019* and 2021*, our researchers published papers showing associations between areas of high ambient air pollution and the frequency of three major eye diseases in the UK population: glaucoma, age-related macular degeneration (AMD) and cataracts – all among the commonest causes of blindness around the world.
The negative effects of PM and nitrogen dioxide on human health are well known, and a recent study estimated this type of pollution is responsible for 8 million excess deaths a year globally*. While the highest levels of toxic air pollution can be found in cities in India and China, many areas of London frequently exceed World Health Organisation guideline limits.
In 2020, for the first time in the UK, air pollution was officially recorded as a cause of death in the case of Ella Kissi-Debrah, a nine-year-old girl. Ella died from a combination of acute respiratory failure, severe asthma and exposure to air pollution, having grown up by a busy road in South London. Around 4,000 people die each year in London as a result of air pollution.
Once PM enters the bloodstream, via the lungs, they can potentially harm any organ in the body, including the eyes. Eye disease and sight loss, while not usually life-threatening, can have a devastating effect on quality of life. Our research shows that tackling air pollution could help to reduce the burden of long-term eye disease for patients. It could also help the NHS, where outpatient visits for ophthalmology (eye care) are higher than for any other area of medicine.
Watch our short video on the links between ambient air pollution and eye disease, and what you can do about it.
*References:
Chua SYL, Khawaja AP, UK Biobank Eye and Vision Consortium, et al. The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort. Investigative Ophthalmology & Visual Science November 2019, Vol.60, 4915-4923. doi: https://doi.org/10.1167/iovs.19-28346
Chua SYL, Warwick A, Peto T on behalf of The UK Biobank Eye and Vision Consortium, et al. Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank. British Journal of Ophthalmology 2022;106:705-711. doi: https://doi.org/10.1136/bjophthalmol-2020-316218
& Sharon Y. L. Chua; Anthony P. Khawaja, et al. The Association of Ambient Air Pollution With Cataract Surgery in UK Biobank Participants: Prospective Cohort Study. Investigative Ophthalmology & Visual Science December 2021, Vol.62, 7. doi: https://doi.org/10.1167/iovs.62.15.7
Karn Vohra, Alina Vodonos, et al. Global mortality from outdoor fine particle pollution generated by fossil fuel combustion: Results from GEOS-Chem. Environmental Research, Volume 195, 2021, 110754, ISSN 0013-9351, doi: https://doi.org/10.1016/j.envres.2021.110754