Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake; it is a powerful appetite suppressant. 

You can expect weight loss in the 8-10lb a month range. Some patients lose more.

• Delays stomach emptying, leading to a feeling of fullness and smaller meal size

• Slows intestinal motility

• Lowers blood sugars, in part by reducing the production of sugar in the liver 

Side Effects: Mild fatigue, intermittent nausea, constipation, and diarrhea. This is not a full list of possible side effects, but the most common we have gotten feedback on. Most are able to be prevented with the additon of B12 and also with increased water intake and nutrition choices. Glycine is added to prevent muscle loss! 

What to Expect: For your initial visit, you will need to schedule an online/telehealth appointment with our office. Before our first appointment, you will have received paperwork online to complete. Then you will have your consultation with the Nurse Practitioner who will use her discretion (based on the FDA recommendations for treating obesity) to determine if semaglutide is a safe and good option for you. She will carefully screen you by evaluating your past medical history, any current medications you take, your vital signs, and your body mass index (BMI). 

You are NOT a good candidate for semaglutide if you have any of the following: diabetic retinopathy, low blood sugar, decreased kidney function, pancreatitis, medullary thyroid cancer (or a family history of medullary thyroid carcinoma), or multiple endocrine neoplasia type 2.

**This is a once weekly subcutaneous injection and the dosage depends on weight loss goals and tolerance. 

**Not for pregnant or breastfeeding mothers!

Tirzepatide works similarly to semaglutide but also targets an additional receptor—glucose-dependent insulinotropic polypeptide (GIP). It works by regulating insulin and glucagon, leading to reduced appetite, delayed gastric emptying, and improved glucose control, all contributing to weight loss. 

Tirzepatide, while more expensive, has shown demonstrated superiority over Semaglutide in reducing weight and therefore provides better value for money than semaglutide for weight reduction.

Side Effects: Mild fatigue, intermittent nausea, constipation, and diarrhea. This is not a full list of possible side effects, but the most common we have gotten feedback on. Most are able to be prevented with the additon of B12 and also with increased water intake and nutrition choices. Glycine is added to prevent muscle loss! 

What to Expect: For your initial visit, you will need to schedule an online/telehealth appointment with our office. Before our first appointment, you will have received paperwork online to complete. Then you will have your consultation with the Nurse Practitioner who will use her discretion (based on the FDA recommendations for treating obesity) to determine if tirzepatide is a safe and good option for you. She will carefully screen you by evaluating your past medical history, any current medications you take and your body mass index (BMI). 

You are NOT a good candidate for tirzepatide if you have any of the following: diabetic retinopathy, low blood sugar, decreased kidney function, pancreatitis, medullary thyroid cancer (or a family history of medullary thyroid carcinoma), or multiple endocrine neoplasia type 2.

**This is a once weekly subcutaneous injection and the dosage depends on weight loss goals and tolerance. 

**Not for pregnant or breastfeeding mothers!

BURN FAT, SUPPRESS APPETITE, BOOST IMMUNITY, AND INCREASE ENERGY

Reduces the storage fat

Suppresses appetite 

Boosts immunity and helps the body fight off infections

Boosts yours metabolism 

Increases your energy

Helps muscles recover quicker after exercise / workouts 

Mega-Burn offers methionine, inositol, choline, plus B-complex vitamins (B-1, B-2, B-3, B-6, B-9, and B-12) that help to metabolize carbohydrates as well as fats. It also contains L-carnitine and Vitamin-C. Together, all these nutrients can aid the body to decrease fat cell production, breakdown stored fat, detoxify the liver and decrease cholesterol levels.  Mega-Burn injections have also been shown to aid in fat oxidation, increase energy, help with lean muscle gains, reduce  hunger, and help boost immunity and fight off infections. Mega-Burn can be taken by itself to help boost weight loss, or it can be taken safely in conjunction with any of our other prescriptive weight loss medications. 

Afraid of injections? Don’t worry, a lot of people are initially concerned about receiving an injection, but at New Leaf Wellness Rx, we allow only trained medical professionals to administer the injections and we use hypodermic needles, which make the pain very minimal and brief. Additionally, the Mega-Burn injection contains a small amount of lidocaine, a common local anesthetic, that helps prevent/relieve itching, pain, or burning that can be associated with injections containing vitamins. 

**Also available in capsule form!! 

**May take home and administer subcutaneously 2x/ week if prefer OR weekly intramuscular injection in office 

**MAY BOOK INJECTION WITHOUT CONSULTATION**

Vitamin B-12 is an essential water-soluble vitamin that influences fat and carbohydrate metabolism, as well as, food absorption. Vitamin B-12 is important for energy production and plays a key role in both a healthy metabolism and immune system. It also serves many biological purposes including healthy cognitive and nerve functions, as well as, memory and emotional well-being. 

Therapeutic use of Vitamin B-12 has been proven effective for fatigue, depression, insomnia, and has even been useful in the treatment of osteoarthritis, bursitis, and asthma.

Vitamin B-12 injections are much more effective than an over-the-counter supplement because intramuscular absorption rate is much higher than pill-form. Your body is able to use it much more efficiently than something which has to pass through your GI system.

**MAY BOOK INJECTION WITHOUT CONSULTATION**

This is a popular peptide combination that stimulates the pituitary gland to release more natural growth hormone (GH) for benefits like improved sleep, metabolism, muscle growth, and fat loss, working synergistically (CJC-1295 prolongs pulses, Ipamorelin triggers them) with fewer side effects than synthetic HGH. While generally well-tolerated with common mild side effects like injection site reactions, it's used in anti-aging and wellness for enhanced recovery, energy, and body composition.

How It Works (Synergy)

• CJC-1295 (Modified GRF 1-29): A GHRH (Growth Hormone-Releasing Hormone) analog that extends the duration of GH release from the pituitary gland.

• Ipamorelin: A ghrelin mimetic that selectively stimulates the pituitary to release GH, without significantly affecting cortisol or prolactin levels.

• Combined Effect: CJC-1295 sustains the release, while Ipamorelin amplifies the strength, creating a powerful, natural, pulsatile GH increase. 

Potential Benefits

• Body Composition: Supports lean muscle gain and fat loss.

• Energy & Recovery: Boosts energy, sharpens focus, and speeds workout recovery.

• Sleep: Promotes deeper, more restorative sleep.

• Anti-Aging: Improves skin tone, hair strength, and overall vitality.

• Metabolism: Supports a healthy metabolism and better glucose utilization. 

Potential Side Effects & Considerations

• Mild Side Effects: Flushing, warmth, pain/redness at injection site, headache, or dizziness.

• FDA Warning: The FDA warns of potential immunogenicity (immune response) and cardiovascular risks (increased heart rate, flushing) for unapproved use.

*Administered subcutaneously 5x per week Monday-Friday(administer at home)

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in every cell of your body, playing a critical role in energy production, metabolism, and cellular repair. 

As we age, our NAD+ levels naturally decline, leading to fatigue, cognitive decline, and a weakened immune system. 

Supplementing with NAD+ injection will help to restore youthful cellular function and delay the aging process.

What it does:

• Energy Production: Acts as a coenzyme in metabolism, transferring electrons to create ATP (cellular energy).

• DNA Repair: Essential for repairing damaged DNA, a key part of cellular maintenance.

• Cellular Signaling: Regulates enzymes involved in protein activity, linking cell energy to stress response. 

Why it's important:

• NAD+ levels naturally fall as we age, linked to fatigue, slower recovery, and age-related conditions.

• Boosting NAD+ is researched for potential anti-aging, improved energy, and better mental clarity. 

Boosting NAD+:

• Precursors: Since NAD+ molecules are too large to enter cells directly, precursors like Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) (Vitamin B3 derivatives) are used to build it inside cells.

• Lifestyle: Exercise, healthy sleep, and a diet rich in B3 (meat, dairy, legumes, fruits) can also help

Potential Side Effects & Considerations

• Mild Side Effects: Flushing, warmth, pain/redness at injection site, headache, or dizziness.

*Administered 3x per week titrating up each week (administer at home)

This compounded weight management capsule combines five active ingredients to target multiple pathways involved in weight loss and overall health. Each component helps to play a unique role in appetite suppression, energy enhancement, and metabolic support, making this a comprehensive approach to achieving weight management goals. Once daily capsule by mouth.

Bupropion promotes weight loss by boosting energy levels and mood while suppressing appetite through its action on noradrenaline, dopamine, and serotonin neurotransmitters. It counteracts stress-induced appetite increases by balancing neurotransmitter activity, leading to better adherence to weight management plans. Clinical evidence shows that bupropion can enhance weight reduction efforts more effectively than diet and exercise alone, making it a valuable tool for weight management.

Methylcobalamin, a form of Vitamin B12, is essential for converting food into glucose, fueling the body’s energy needs. This process is key to maintaining an efficient metabolism, which aids in weight management. Additionally, sufficient levels of methylcobalamin ensure the nervous system functions effectively, boosting energy levels and potentially increasing physical activity, indirectly facilitating weight loss. B12 is also pivotal in producing red blood cells, vital for oxygen transport, further improving metabolism and energy.

Naltrexone HCI, particularly at low doses, plays a role in reducing insulin resistance, a key factor in managing body weight. It helps in regulating appetite, ensuring a balance in food intake. Additionally, naltrexone HCI exhibits anti-inflammatory properties. Chronic inflammation can lead to hormonal imbalances that predispose individuals to weight gain by affecting metabolism and appetite control. By addressing inflammation, naltrexone HCI may help mitigate these hormonal changes, supporting efforts towards weight management.

Phentermine HCI works to curb appetite by inhibiting the reabsorption of key neurotransmitters in the brain such as norepinephrine, serotonin, and dopamine, all of which play a crucial role in regulating hunger and the feeling of satiety. It specifically acts on the brain’s appetite control center to reduce hunger sensations. 

Topiramate, primarily used as an anticonvulsant and for migraine prevention, has been observed to influence weight loss through appetite suppression, leading to reduced caloric intake. It may also alter taste preferences, which can decrease the desire for high-calorie, fatty foods. Additionally, topiramate’s effects on insulin sensitivity and energy expenditure could further contribute to its weight-loss properties.

**Naltrexone can cause vivid dreams the first few weeks of therapy. Most common side effects include fatigue, insomnia, flu-like symptoms, decreased appetite, anxiety, headache, or dizziness. Do not use LDN treatment if you are receiving opioid analgesics, dependent on opioids.

**Phentermine can increase blood pressure and heart rate, and is therefore contraindicated in individuals with a history of heart disease, uncontrolled high blood pressure, coronary artery disease, arrhythmias, or stroke. 

**Not for pregnant or breastfeeding mothers!

Methylene blue has recently gained significant attention in wellness communities and among biohackers for its potential anti-aging and cognitive-enhancing properties. Early research in lab and animal studies have shown benefits in: 

• Cognitive Support: Improving memory, focus, and mental clarity by enhancing mitochondrial function and protecting brain cells from oxidative stress.

• Anti-aging: Protecting cells from age-related damage, leading to its inclusion in some skincare products.

• Antimicrobial Effects: Showing potential in light-activated treatments for drug-resistant bacteria, fungi, and viruses. 

Potential Side Effects & Considerations

• Serotonin Syndrome: Methylene blue is a potent monoamine oxidase inhibitor (MAOI). Combining it with other serotonergic medications like many antidepressants (SSRIs, SNRIs, MAOIs) can lead to dangerously high serotonin levels, a life-threatening condition called serotonin syndrome.

• G6PD Deficiency: People with a rare genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid methylene blue, as it can cause severe anemia.

• Side Effects: Common side effects include blue- or green-colored urine and skin, headache, nausea, and dizziness.

*Administered by mouth via capsules once daily

Low-dose naltrexone (LDN) provides a temporary blockade of opioid receptors resulting in a rebound effect, yielding an increase in endorphin production. This boost in endorphins aids in healing, regulates immunity, promotes pain relief, and helps reduce inflammation. Therapeutic benefits of LDN are evident in autoimmune diseases, gastrointestinal disorders, chronic pain, mental health challenges, and inflammation. Works great in addition to GLP-1 therapy!! 

Potential Clinical Uses of LDN: 

* Addiction * Addison’s Disease * Alopecia Areata * Alzheimer’s Disease * Ankylosing Spondylitis * Anxiety * Atopic Dermatitis * Chronic Fatigue Syndrome (CFS) How Supplied: FLEX-DOSE TABLETS * Chronic Pain * Complex Regional Pain Syndrome * Crohn’s Disease * Eczema * Fibromyalgia * Hashimoto’s Disease * Hypothyroidism * Inflammatory Bowel Disease * Irritable Bowel Syndrome * Kawasaki’s Disease * Lyme Disease * Lupus * Meniere’s Disease * Migraine Headaches * Multiple Sclerosis (MS) * Obsessive Compulsive Disorder (OCD)

Potential Side Effects & Considerations

• LDN can cause vivid dreams the first few weeks of therapy. Most common side effects include fatigue, insomnia, flu-like symptoms, decreased appetite, anxiety, headache, or dizziness. 

• Do not use LDN treatment if you are receiving opioid analgesics, dependent on opioids.

*Administered by mouth daily: Take 1.125 mg to 1.5 mg by mouth at bedtime for 7 to 14 days, then increase to 2.25 mg to 3 mg at bedtime for 7 to 14 days, then increase to 4.5 mg at bedtime thereafter.

**Not for pregnant or breastfeeding mothers!

Glutathione injections are used for delivering a concentrated dose of Glutathione, a powerful antioxidant, directly into the bloodstream for optimal absorption and effectiveness. The primary uses of Glutathione include:

Detoxification: Glutathione is vital for neutralizing and eliminating toxins from the body, supporting liver function, and promoting overall detoxification.

Antioxidant support: As a powerful antioxidant, glutathione helps protect cells from oxidative stress and damage, maintaining overall cellular health.

Skin brightening: Glutathione injections may help lighten and brighten the skin, reducing hyperpigmentation and promoting a more even skin tone.

Improved energy levels: Glutathione supports cellular energy production, and may help boost energy levels and reduce fatigue.

Strengthening the immune system: Glutathione plays a crucial role in maintaining a healthy immune system by supporting immune cell function and combating oxidative stress.

CONDITIONS TREATED WITH GLUTATHIONE:

Individuals with conditions that are associated with oxidative stress, inflammation, and/or

compromised immune function may benefit from glutathione supplementation.

* Chronic Fatigue Syndrome * Parkinson’s Disease * Alzheimer’s Disease * Multiple Sclerosis 

* Rheumatoid Arthritis * Inflammatory Bowel Disease * Chronic Obstructive Pulmonary Disease (COPD) * Asthma 

*Administered in a dissolvable troche in the cheek daily 

Accelerated Tissue Healing: TB-500 is associated with faster recovery from injuries affecting muscles, tendons, ligaments, and other soft tissues, including internal organs and skin. It helps improve the tensile strength of healing tissues and reduce scar formation.

Reduced Inflammation: The peptide has anti-inflammatory properties that may help calm inflammatory pathways, relieve chronic pain, and reduce stiffness associated with injury or chronic conditions.

Improved Flexibility and Mobility: By supporting tissue regeneration and reducing the formation of scar tissue, TB-500 can enhance range of motion and flexibility in joints and muscles.

Cellular Regeneration and Migration: It promotes the formation of actin, a protein vital for cell movement and migration to injury sites, which is essential for the body's natural repair mechanisms.

Angiogenesis (New Blood Vessel Growth): TB-500 stimulates the growth of new blood vessels, which improves circulation and the delivery of oxygen and nutrients to damaged tissues, further supporting the healing process.

Muscle Maintenance and Growth: It may help maintain muscle mass and support muscle growth, which can be beneficial for individuals experiencing muscle wasting due to illness or injury.

Cardiovascular Support: Research in animal models suggests potential benefits for the cardiovascular system, including support for vascular repair and recovery from heart injuries. 

Potential Side Effects: 

While often reported as mild (injection pain, swelling, headache), allergic reactions, infections, and blood pressure changes are possible. 

Who Should Avoid these Injections

• Pregnant or breastfeeding individuals.

• People with active cancer or high risk.

*Administered subcutaneously titrating up each week (administer at home)

*Works best if taken in conjunction with BPC-157 (Wolverine Pack)

*ONLY used for acute muscle/tendon/ligament or soft tissue injuries and for no longer than 3 months!

The Glow blend combines the unique properties of each peptide to support comprehensive regeneration and repair. 

• GHK-Cu (Copper Tripeptide): This naturally occurring peptide is renowned for its anti-aging capacity. It stimulates collagen and elastin production, improves skin elasticity and firmness, reduces inflammation, and promotes hair growth.

• BPC-157 (Body Protection Compound-157): Derived from stomach proteins, BPC-157 enhances tissue repair and reduces inflammation throughout the body, particularly in muscles, tendons, ligaments, and the gut.

• TB-500 (Thymosin Beta-4 analogue): This peptide supports cellular regeneration, tissue remodeling, muscle recovery, and enhances flexibility. It promotes cell migration and blood vessel formation (angiogenesis). 

Common Side Effects (Especially at Injection Site)

• Redness, Swelling, & Discomfort: Mild redness, minor swelling, or slight soreness where injected, usually resolving quickly. 

• Itching/Tingling: A sensation of itching or tingling at the site of application or injection

Who Should Avoid GHK-Cu Injections

• Pregnant or breastfeeding individuals.

• People with active cancer or high risk.

• Individuals with copper metabolism disorders (like Wilson's disease).

• Those with known allergies to copper compounds or peptides. 

*Administered under the skin 20 units Monday-Friday and can only be cycled for 3 months at a time.

A small peptide produced by mitochondria that helps regulate cellular energy, metabolism (like glucose and muscle), insulin sensitivity, and protects against age-related decline, with exercise boosting its production; it's being studied for conditions like diabetes and osteoporosis but is banned by WADA for athletes.  

Key functions & benefits:

• Metabolic Health: Enhances glucose metabolism, improves insulin sensitivity, and helps regulate body weight. 

• Muscle Health: Regulates skeletal muscle metabolism, improves physical performance, and protects against muscle atrophy. 

• Bone Health: Promotes bone formation and inhibits bone loss, potentially helping with osteoporosis. 

• Disease Potential: Shows promise in alleviating symptoms of metabolic disorders like gestational diabetes (GDM) and insulin resistance. 

Commonly Reported Side Effects:

Most reported side effects for MOTS-c are mild and often associated with the injection process or initial adjustment period. These include: 

• Injection site reactions: Redness, irritation, or discomfort at the site of injection.

• Headaches.

• Gastrointestinal issues: Slight nausea or stomach discomfort.

• Fatigue or insomnia: Some people report slight fatigue, while others experience insomnia.

*Administered subcutaneously twice weekly (at home)

Semax is a synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), specifically engineered for neuroprotective and cognitive enhancement applications. Developed through systematic peptide modification research in Russia, Semax (Met-Glu-His-Phe-Pro-Gly-Pro) represents a breakthrough in rational peptide design, optimized to enhance cognitive function while providing robust protection against neurological injury without the hormonal side effects of native ACTH.

This peptide has gained considerable attention in neurology and cognitive medicine due to its demonstrated multifaceted benefits in stroke recovery, traumatic brain injury rehabilitation, and cognitive performance optimization through comprehensive modulation of neurotransmitter systems, gene expression regulation, and neuroprotective pathways. Semax exhibits excellent CNS penetration via intranasal administration and maintains bioactivity across various physiological conditions, making it unique among neuroprotective peptides.

What it's used for: 

• Cognitive Enhancement: Improving memory, learning, attention, and focus.

• Neuroprotection: Protecting neurons from damage (e.g., oxidative stress).

• Recovery: Aiding recovery from stroke, brain trauma, and neurological deficits.

• Conditions Studied: ADHD, Rett syndrome, Parkinson's, Alzheimer's, and nerve regeneration.

Side Effects: 

• Generally well-tolerated, with low systemic toxicity.

• Mild effects can include nasal irritation, restlessness, or headaches.

*Administered via nasal spray 1 spray each nostril once daily

Selank is a synthetic heptapeptide consisting of seven amino acids (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the naturally occurring immunoregulatory peptide tuftsin. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in cooperation with the V.V. Zakusov Research Institute of Pharmacology, Selank represents a metabolically stable analog of the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) found in human immunoglobulin G heavy chains.

This peptide has gained considerable attention in neuropsychopharmacology due to its demonstrated anxiolytic and nootropic effects in both preclinical and clinical studies, particularly in anxiety management, cognitive enhancement, and mood regulation. Selank exhibits remarkable stability compared to its endogenous counterpart and maintains bioactivity through modulation of GABAergic, dopaminergic, and serotonergic neurotransmitter systems, making it unique among therapeutic peptides.

What it's used for: 

• Anxiety Reduction: Reduces anxiety and emotional stress, with some users experiencing effects within days.

• Cognitive Enhancement: Improves focus, learning, memory, and attention, particularly in stress-related deficits.

• Antidepressant-like Effects: Shows promise in animal models of depression.

• Anti-inflammatory: Helps decrease inflammation.

Side Effects: 

• Generally well-tolerated, with minimal sedation; reported side effects include mild headaches, sinus irritation, or soreness at the injection site.

• Regulation: Approved in Russia for anxiety and nootropic use, but not FDA-approved in the U.S. for general treatment. 

*Administered via nasal spray 1 spray each nostril once daily

Also known by the generic name bremelanotide, is a synthetic peptide used to treat hypoactive (low) sexual desire disorder (HSDD) in premenopausal women. It works on the brain's melanocortin receptors to increase sexual desire and arousal, rather than affecting the vascular system like traditional erectile dysfunction medications. 

PT-141 is FDA-approved for the treatment of generalized HSDD in premenopausal women who experience low sexual desire that causes personal distress and is not due to another medical condition, relationship problems, or medication use.

Many women report significant improvements in sexual desire and satisfaction, with effects often felt within a few hours and lasting for up to 12-72 hours, depending on the individual.

While not FDA-approved for men, PT-141 is used off-label to treat erectile dysfunction and low libido, sometimes in combination with PDE-5 inhibitors like Viagra, for those who haven't responded adequately to traditional treatments. 

Side Effects

• Common Side Effects: Nausea, flushing (warmth and redness), headache.

• Less Common Side Effects: Dizziness, fatigue.

• Warnings: PT-141 may cause a temporary increase in blood pressure and decrease in heart rate after each dose. It is contraindicated for individuals with uncontrolled hypertension or known cardiovascular disease. 

*Administered 1 spray each nostril 1-4 hours before sex and a maximum of 8 doses per month.