Effective wound healing is essential, but abnormal repair can lead to scarring, marked by excess extracellular matrix and inflammation. TGFβ regulates key healing processes, but systemic inhibition to reduce scarring causes side effects and impairs re-epithelization. We developed a photo-responsive wound dressing with microcapsules for pulsatile  TGFβ inhibitor release, promoting wound closure and minimizing scarring. This approach offers a new strategy for scarless healing.

Nature Communications. 2021

https://www.nature.com/articles/s41467-021-21964-0

Metabolic reprogramming, particularly the Warburg Effect (accumulation of lactate), is a hallmark of cancer. This study develops a lactate-responsive drug delivery platform targeting this effect using gold/mesoporous silica Janus nanoparticles. Lactate oxidase on the gold triggers drug release in the presence of lactate. This platform shows enhanced drug specificity and therapeutic efficacy for cancer treatment, offering a novel approach to metabolically targeted drug delivery.

Cell Reports Medicine. 2025 

https://www.sciencedirect.com/science/article/pii/S2666379124006918?via%3Dihub