About me!

Position

• Associate Professor - Department of Chemistry and Physics at Mount Royal University

• Adjunct Professor - Department of Biochemistry and Molecular Biology at University of Calgary

Education

• Ph.D. - Princeton University (Protein Crystallography/Chemistry)

• B.Sc. - University of Toronto (Chemical Physics and History of Science and Technology)

Scientific Research Interests

• Cosolute Effects on enzyme kinetics, inhibition and specificity

• Soil Enzymology and enzymes in heterogeneous environments

• Protein hydration

• General Biophysics/Biochemistry

• Mass Spectrometry

  • Hydrogen/Deuterium Exchange Mass spectrometry

  • Proteomics

Scholarship of Teaching in Learning Interests

• Better understanding and utilization of laboratory work in science education (REAL Labs and CSL)

• Part of the Nexen Scholars Program (2016) in the Institute for Scholarship of Teaching and Learning at Mount Royal University

Recent Publications

• Yavorska, O. A., Syriste, L., du Plessis, C. M., Yaqoob, M., Loogman, K., Cordara, M., & Chik, J. K. (2021). Cosolutes modify alkaline phosphatase catalysis through osmotic stress and crowding mechanisms. ACS Omega, acsomega.1c03243. https://doi.org/10.1021/acsomega.1c03243 (Open Data: doi.org/10.5683/SP2/N7ZKXV )

• MacDonald JA, Ishida H, Butler EI, Ulke-Lemée A, Chappellaz M, Tulk SE, Chik JK, Vogel HJ. Intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding. Biochemistry. 2012 Apr 3;51(13):2694-705. doi:10.1021/bi2019018. Epub 2012 Mar 22. PubMed PMID: 22424482.

• Chik JK, Schriemer DC, Childs SJ, McGhee JD. Proteome of the Caenorhabditis elegans oocyte. J Proteome Res. 2011 May 6;10(5):2300-5. doi: 10.1021/pr101124f. Epub 2011 Apr 15. PubMed PMID: 21452892.

• Bennett MJ, Chik JK, Slysz GW, Luchko T, Tuszynski J, Sackett DL, Schriemer DC. Structural mass spectrometry of the alpha beta-tubulin dimer supports a revised model of microtubule assembly. Biochemistry. 2009 Jun 9;48(22):4858-70. doi: 10.1021/bi900200q. Erratum in: Biochemistry. 2009 Oct 13;48(40):9704. PubMed PMID: 19388626; PubMed Central PMCID: PMC4129956.

• Huzil JT, Chik JK, Slysz GW, Freedman H, Tuszynski J, Taylor RE, Sackett DL, Schriemer DC. A unique mode of microtubule stabilization induced by peloruside A. J Mol Biol. 2008 May 16;378(5):1016-30. doi: 10.1016/j.jmb.2008.03.026. Epub 2008 Mar 19. PubMed PMID: 18405918; PubMed Central PMCID: PMC2441936.

• Chik J, Mizrahi S, Chi S, Parsegian VA, Rau DC. Hydration forces underlie the exclusion of salts and of neutral polar solutes from hydroxypropylcellulose. J Phys Chem B. 2005 May 12;109(18):9111-8. PubMed PMID: 16852084.

• Chik JK, Vande Graaf JL, Schriemer DC. Quantitating the statistical distribution of deuterium incorporation to extend the utility of H/D exchange MS data. Anal Chem. 2006 Jan 1;78(1):207-14. PubMed PMID: 16383329.

• Chik JK, Schriemer DC. Hydrogen/deuterium exchange mass spectrometry of actin in various biochemical contexts. J Mol Biol. 2003 Nov 28;334(3):373-85. PubMed PMID: 14623181.