Lab Members
Hongbing Wang, PhD, Principal Investigator
I received my B.S. in Cell Biology from Peking University. My Ph.D. thesis was performed at UCLA under the supervision of Dr. Richard Olsen. I learned to examine brain activity and animal behavior while I did my postdoc work with Dr. Daniel Storm at University of Washington.
My long-term research interests are to elucidate molecular and cellular mechanisms underlying memory formation and forgetting. I hope that some outcomes from these basic research directions may lead to therapeutic strategies for the treatment of pathological conditions including Fragile X syndrome, autism, and mood disorders.
E-mail: wangho@msu.edu; Phone: 517-884-5119.
Qi Ding, PhD, Research Assistant Professor
I am investigating homeostatic control of gene expression in neurons. My other efforts are dedicated to understand molecular underpinnings of pathophysiology associated with Bipolar disorder and Fragile X syndrome.
Publications:
Xianju Zhou, Qi Ding, Zhuoyou Chen, Huifang Yun, and Hongbing Wang (2013) Involvement of GluN2A and GluN2B in synaptic and extrasynaptic NMDA receptor function and neuronal excitotoxicity. J Biol Chem. 288(33):24151-9. PMCID: PMC3745357.
Qi Ding, Ferzin Sethna, and Hongbing Wang (2014) Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background. Behavioural Brain Res. 271:72-78. PMCID: PMC4104211.
Zixiang Song, Qi Chen, Qi Ding, Fei Zheng, Chengwei Li, Leping Wu, and Hongbing Wang (2015) Function of Ca2+-/calmodulin-dependent protein kinase IV in Ca2+-stimulated neuronal signaling and behavior. Sci China Life Sci. 58:6-13.
Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
Ferzin Sethna, Wei Feng, Qi Ding, Alfred J. Robison, Yue Feng, Hongbing Wang (2017) Enhanced expression of ADCY1 underlies aberrant neuronal signaling and behavior in a syndromic autism model. Nature Communications. Feb 20;8:14359.
Qi Ding, Ferzin Sethna, Xue-Ting Wu, Zhuang Miao, Ping Chen, Yueqi Zhang, Hua Xiao, Wei Feng, Yue Feng, Xuan Li, Hongbing Wang (2020) Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model. Communications Biology. Mar 16;3(1):127. doi: 10.1038/s42003-020-0833-4.
Qi Ding, Fan Zhang, Yue Feng, Hongbing Wang (2020) Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome. Int J Mol Sci 21 (23), 9327; https://doi.org/10.3390/ijms21239327.
# Miyoung Yang*, Qi Ding*, Ming Zhang, Changjong Moon, Hongbing Wang (2020) Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress. Neurobiology of Stress. https://doi.org/10.1016/j.ynstr.2020.100237. * equal contribution.
# Qi Ding, Xueting Wu, Xuan Li, Hongbing Wang (2022) Vorinostat corrects cognitive and non-cognitive symptoms in a mouse model of fragile X syndrome. The International Journal of Neuropsychopharmacology. 25 (2): 147-159.
Jiao Chen, Qi Ding, Lulu An, Hongbing Wang (2022) Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders. Front. Pharmacol. 13:949384. doi: 10.3389/fphar.2022.949384
Yuen Gao, PhD, Research Associate
I investigate the function of nucleolus in neurons and glial cells.
Lulu An, MS, Graduate Student
I investigate the function of the Ca-stimulated ADCY8 in regulating neuronal signaling and adaptive behavior.
Publications:
Jiao Chen, Qi Ding, Lulu An, Hongbing Wang (2022) Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders. Front. Pharmacol. 13:949384. doi: 10.3389/fphar.2022.949384
Nicholas Williams, BS, Research Assistant
I investigate the function of cAMP signaling in regulating synaptic plasticity with acute hippocampal slices.
Ziyi Li, MS, Graduate Student
I use a genetic model to study the mechanisms underlying PTSD.