Alumni
Fei Zheng
PhD student (2006-2011); currently scientist at St. Jude Children's Research Hospital
Published work from Wang lab:
1. Ming Zhang, Changjong Moon, Guy Chan, Lan Yang, Fei Zheng, Alana Conti, Lisa Muglia, Louis Muglia, Daniel Storm, and Hongbing Wang. (2008) Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J. Neurosci. 28 (18): 4736-4744. PMCID: PMC2865254.
2. Fei Zheng, Deborah Soellner, Jopseph Nunez, and Hongbing Wang. (2008) The basal level of intracellular calcium gates the activation of phosphoinositide 3-kinase -Akt signaling by brain-derived neurotrophic factor in cortical neurons. J. Neurochem. 106 (3): 1259-1274. PMCID: PMC2574892.
3. Fei Zheng, Yongneng Luo, and Hongbing Wang. (2009). Regulation of BDNF-mediated transcription of immediate early gene Arc by intracellular calcium and calmodulin. J. Neurosci. Res. 87(2):380-392. PMCID: PMC2628963.
4. Fei Zheng and Hongbing Wang. (2009) NMDA-mediated and Self-induced Bdnf Exon IV Transcriptions are Differentially Regulated in Cultured Cortical Neurons. Neurochem Int. 54:385-392. PMCID: PMC2722960.
5. Xianju Zhou, Changjong Moon, Fei Zheng, Yongneng Luo, Deborah Soellner, Jopseph Nunez, and Hongbing Wang. (2009) NMDA-stimulated ERK1/2 signaling and the transcription of plasticity-related genes are developmentally regulated following in vitro neuronal maturation. J. Neurosci . Res. 87:2632-44. PMCID: PMC2857719.
6. Yan Wang, Fei Zheng, Xianju Zhou, Zhongsheng Sun, and Hongbing Wang. (2009) Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. Neurosci Lett. 460: 36-40. PMCID: PMC2726798.
7. Xianju Zhou, David S. Lin, Fei Zheng, Michael A Sutton, and Hongbing Wang. (2010) Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis. J. Neurosci . Res. 88(7):1420-32. PMCID: PMC2857705.
8. Fei Zheng, Xianju Zhou, Hua Xiao, Gary Wayman, and Hongbing Wang. (2011) Regulation of Brain-derived Neurotrophic Factor Exon IV Transcription Through Calcium Responsive Elements In Cortical Neurons. PLoS ONE 6(12):e28441. PMCID: PMC3235121.
9. Xianju Zhou, Fei Zheng, Changjong Moon, Oliver M. Schlüter, and Hongbing Wang (2012) Bi-directional regulation of CaMKIIα phosphorylation at Thr286 by NMDA receptors in cultured cortical neurons. J. Neurochem. 122:295-307. PMCID: PMC3434305.
10. Fei Zheng, Xianju Zhou, Changjong Moon, and Hongbing Wang (2012) Regulation of brain-derived neurotrophic factor expression in neurons. Int J Physiol Pathophysiol Pharmacol. 4 (4): 188-200. PMCID: PMC3544221
11. Zixiang Song, Qi Chen, Qi Ding, Fei Zheng, Chengwei Li, Leping Wu, and Hongbing Wang (2015) Function of Ca2+-/calmodulin-dependent protein kinase IV in Ca2+-stimulated neuronal signaling and behavior. Sci China Life Sci. 58:6-13.
12. Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
Ming Zhang
Postdoc Research Associate (2007-2011); Currently Professor at Kunming Medical University
Published work from Wang lab:
1. Ming Zhang, Changjong Moon, Guy Chan, Lan Yang, Fei Zheng, Alana Conti, Lisa Muglia, Louis Muglia, Daniel Storm, and Hongbing Wang. (2008) Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J. Neurosci. 28 (18): 4736-4744. PMCID: PMC2865254.
2. Yan Wang, Ming Zhang, Changjong Moon, Qubai Hu, Baiping Wang, George Martin, Zhongsheng Sun, Hongbing Wang. (2009) The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation. Learn Mem. 16:537-44.
3. Ming Zhang, Daniel Storm, and Hongbing Wang. (2011) Bidirectional synaptic plasticity and spatial memory flexibility require Ca2+-stimulated adenylyl cyclases. J. Neurosci. 31(28): 10174-183. PMCID: PMC3145492
4. Hongbing Wang and Ming Zhang. (2012) The role of Ca2+-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function. Rev. Neurosci. 23(1):67-78.
5. Ming Zhang and Hongbing Wang (2013) Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression. Learn Mem. 20: 352-357. PMCID: PMC3687257.
6. Ferzin Sethna, Ming Zhang, Hanoch Kaphzan, Eric Klann, Dawn Autio, Charles L Cox, Hongbing Wang (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res. 94:401-408.
7. Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
Xianju Zhou
Postdoc Research Associate (2007-2012); Currently Professor at The Affiliated Hospital of Nanjing Medical University
Published work from Wang lab:
1. Xianju Zhou, Changjong Moon, Fei Zheng, Yongneng Luo, Deborah Soellner, Jopseph Nunez, and Hongbing Wang. (2009) NMDA-stimulated ERK1/2 signaling and the transcription of plasticity-related genes are developmentally regulated following in vitro neuronal maturation. J. Neurosci . Res. 87:2632-44. PMCID: PMC2857719.
2. Yan Wang, Fei Zheng, Xianju Zhou, Zhongsheng Sun, and Hongbing Wang. (2009) Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. Neurosci Lett. 460: 36-40. PMCID: PMC2726798.
3. Xianju Zhou, David S. Lin, Fei Zheng, Michael A Sutton, and Hongbing Wang. (2010) Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis. J. Neurosci . Res. 88(7):1420-32. PMCID: PMC2857705.
4. Xianju Zhou, Hua, Xiao, and Hongbing Wang (2011) Developmental changes of TrkB signaling in response to exogenous BDNF in primary cortical neurons. J. Neurochem. 119(6):1205-16. PMCID: PMC3230766.
5. Fei Zheng, Xianju Zhou, Hua Xiao, Gary Wayman, and Hongbing Wang. (2011) Regulation of Brain-derived Neurotrophic Factor Exon IV Transcription Through Calcium Responsive Elements In Cortical Neurons. PLoS ONE 6(12):e28441. PMCID: PMC3235121.
6. Xianju Zhou, Fei Zheng, Changjong Moon, Oliver M. Schlüter, and Hongbing Wang (2012) Bi-directional regulation of CaMKIIα phosphorylation at Thr286 by NMDA receptors in cultured cortical neurons. J. Neurochem. 122:295-307. PMCID: PMC3434305.
7. Fei Zheng, Xianju Zhou, Changjong Moon, and Hongbing Wang (2012) Regulation of brain-derived neurotrophic factor expression in neurons. Int J Physiol Pathophysiol Pharmacol. 4 (4): 188-200. PMCID: PMC3544221
8. Xianju Zhou, Daniel Hollern, Jiayu Liao, Eran Andrechek, and Hongbing Wang (2013) NMDA receptor-mediated excitotoxicity depends on the co-activation of synaptic and extrasynaptic receptors. Cell Death & Disease. 4:e560. doi: 10.1038/cddis.2013.82. PMCID: PMC3615746.
9. Xianju Zhou1, Qi Ding, Zhuoyou Chen, Huifang Yun, and Hongbing Wang (2013) Involvement of GluN2A and GluN2B in synaptic and extrasynaptic NMDA receptor function and neuronal excitotoxicity. J Biol Chem. 288(33):24151-9. PMCID: PMC3745357.
10. Chen Z, Zhou Q, Zhang M, Wang H, Yun W, Zhou X (2014) Co-activation of synaptic and extrasynatpic NMDA receptors by neuronal insults determines cell death in acute brain slice. Neurochem Int. 78:28-34.
11. Zhou X, Chen Z, Yun W, Wang H (2015) NMDA receptor activity determines neuronal fate: location or number? Rev Neurosci. 26(1):39-47.
12. Xianju Zhou, Zhuoyou Chen, Wenwei Yun, J Ren, Chenwei Li, and Hongbing Wang (2015) Extrasynaptic NMDA Receptor in Excitotoxicity: Function Revisited. The Neuroscientist. (4):337-44.
Yan Wang
Visiting PhD student (2008-2010); currently Associate Professor at Beijing Institute of Life Science
Published work from Wang lab:
1. Yan Wang, Fei Zheng, Xianju Zhou, Zhongsheng Sun, and Hongbing Wang. (2009) Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. Neurosci Lett. 460: 36-40. PMCID: PMC2726798.
2. Yan Wang, Ming Zhang, Changjong Moon, Qubai Hu, Baiping Wang, George Martin, Zhongsheng Sun, Hongbing Wang. (2009) The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation. Learn Mem. 16:537-44.
Changjong Moon, Postdoc Research Associate (2006-2007); visiting professor (2014-2015); currently Professor at Chonnam National University
Published work from Wang lab:
1. Ming Zhang, Changjong Moon, Guy Chan, Lan Yang, Fei Zheng, Alana Conti, Lisa Muglia, Louis Muglia, Daniel Storm, and Hongbing Wang. (2008) Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J. Neurosci. 28 (18): 4736-4744. PMCID: PMC2865254.
2. Xianju Zhou, Changjong Moon, Fei Zheng, Yongneng Luo, Deborah Soellner, Jopseph Nunez, and Hongbing Wang. (2009) NMDA-stimulated ERK1/2 signaling and the transcription of plasticity-related genes are developmentally regulated following in vitro neuronal maturation. J. Neurosci . Res. 87:2632-44. PMCID: PMC2857719.
3. Yan Wang, Ming Zhang, Changjong Moon, Qubai Hu, Baiping Wang, George Martin, Zhongsheng Sun, Hongbing Wang. (2009) The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation. Learn Mem. 16:537-44.
4. Xianju Zhou, Fei Zheng, Changjong Moon, Oliver M. Schlüter, and Hongbing Wang (2012) Bi-directional regulation of CaMKIIα phosphorylation at Thr286 by NMDA receptors in cultured cortical neurons. J. Neurochem. 122:295-307. PMCID: PMC3434305.
5. Fei Zheng, Xianju Zhou, Changjong Moon, and Hongbing Wang (2012) Regulation of brain-derived neurotrophic factor expression in neurons. Int J Physiol Pathophysiol Pharmacol. 4 (4): 188-200. PMCID: PMC3544221
6. Ferzin Sethna, Changjong Moon, and Hongbing Wang. (2014) From FMRP Function to Potential Therapies for Fragile X Syndrome. Neurochem. Res. 39(6):1016-31. PMCID: PMC4024105.
7. Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
8. Sueun Lee, Miyoung Yang, Juhwan Kim, Yeonghoon Son, Jinwook Kim, Sohi Kang, Wooseok Ahn, Sung-Ho Kim, Jong-Choon Kim, Taekyun Shin, Hongbing Wang, Changjong Moon (2016) Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull. 121:48-58.
Miyoung Yang, Postdoc Research Associate (2014-2016); currently Associate Professor at Wonkwang University
Published work from Wang lab:
# Miyoung Yang*, Qi Ding*, Ming Zhang, Changjong Moon, Hongbing Wang (2020) Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress. Neurobiology of Stress. https://doi.org/10.1016/j.ynstr.2020.100237. * equal contribution.
Duanghathai Wiwatratana, Neuroscience Program Mater degree student (2011-2012)
Ferzin Sethna, Ph.D. Student (2009-2014); Postdoc Fellow (2014-2015); currently a scientist at SwanBio.
Published work from Wang lab:
1. Ferzin Sethna, Changjong Moon, and Hongbing Wang. (2014) From FMRP Function to Potential Therapies for Fragile X Syndrome. Neurochem. Res. 39(6):1016-31. PMCID: PMC4024105.
2. Qi Ding, Ferzin Sethna, and Hongbing Wang (2014) Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background. Behavioural Brain Res. 271:72-78. PMCID: PMC4104211.
3. Ferzin Sethna and Hongbing Wang (2014) Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction. Learn Mem. 21:647-650. PMCID: PMC4236415.
4. Ferzin Sethna and Hongbing Wang (2016) Acute inhibition of mGluR5 disrupts behavioral flexibility. Neurobiol Learn Mem. 130:1-6.
5. Ferzin Sethna, Ming Zhang, Hanoch Kaphzan, Eric Klann, Dawn Autio, Charles L Cox, Hongbing Wang (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res. 94:401-408.
6. Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
7. Ferzin Sethna, Wei Feng, Qi Ding, Alfred J. Robison, Yue Feng, Hongbing Wang (2017) Enhanced expression of ADCY1 underlies aberrant neuronal signaling and behavior in a syndromic autism model. Nature Communications. Feb 20;8:14359.
8. Qi Ding, Ferzin Sethna, Xue-Ting Wu, Zhuang Miao, Ping Chen, Yueqi Zhang, Hua Xiao, Wei Feng, Yue Feng, Xuan Li, Hongbing Wang (2020) Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model. Communications Biology. Mar 16;3(1):127. doi: 10.1038/s42003-020-0833-4.
Fan Zhang, visiting scholar (2014-2015); currently Instructor at Zhoukou Normal University.
Qi Ding, Fan Zhang, Yue Feng, Hongbing Wang (2020) Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome. Int J Mol Sci 21 (23), 9327; https://doi.org/10.3390/ijms21239327.
Thaddeus Kunkel, Undergraduate Researcher (2015-2017); currently PhD student at University of Michigan
Published work from Wang lab:
1. Thaddeus Kunkel and Hongbing Wang (2018) Socially dominant mice in C57BL6 background show increased social motivation. Behavioural Brain Research. 336:173-176.
Zhuang Miao, Postdoc research associate (2017-2018); currently scientist at University of Toronto
Published work from Wang lab:
Qi Ding, Ferzin Sethna, Xue-Ting Wu, Zhuang Miao, Ping Chen, Yueqi Zhang, Hua Xiao, Wei Feng, Yue Feng, Xuan Li, Hongbing Wang (2020) Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model. Communications Biology. Mar 16;3(1):127. doi: 10.1038/s42003-020-0833-4.
Jillian Matasovsky, Research Assistant (2020-2021); currently graduate student at Wayne State University
Jiao Chen, Postdoc Research Associate (2020-2022); currently instructor at Wenzhou Medical University