current projects

T. Frazier, S. Lee, A. Bowles, J.A. Semon, B.A. Bunnell, X. Wu, J. Gimble. Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction. Adipocyte, DOI: 10.1080/21623945.2018.1460009 (2018)

A novel biomaterial invented by collaborators at S&T is made of borate bioactive glass fibers. It has recently been used successfully in the clinic to treat chronic, nonhealing dermal wounds, often without scarring. Despite it’s success, it is unclear how the biomaterial heals wounds. Because adipose derived MSCs (ASCs) have been demonstrated to have multiple roles in wound healing, this project investigates the effects of the borate bioactive glass fibers on ASCs from different sources.

N.J. Thyparambil, L.C. Gutgesell, B.A. Bromet, L.E. Flowers, S. Greaney, D.E. Day, J.A. Semon. Bioactive borate glass triggers phenotypic changes in adipose stem cells. J Mater Sci: Mater Med 31, 35. https://doi.org/10.1007/s10856-020-06366-w (2020)

N.J. Thyparambil, L.C. Gutgesell, C.C. Hurley, L.E. Flowers, D.E. Day, J.A. Semon. Adult stem cell response to doped bioactive borate glass. J Mater Sci: Mater Med 31, 13. https://doi.org/10.1007/s10856-019-6353-4 (2020)

With collaborators, we've developed a novel method to bioprint ASCs and bioactive glass. This technique produces flexible, angiogenic scaffolds that can be personalized per patient.

K.C.R. Kolan, J.A. Semon, A. Bindbeutel, D.E. Day, and M. Leu. Bioprinting with bioactive glass loaded polylactic acid composite and human adipoe stem cells. Bioprinting, 18:e00075 (2020)

K.C.R. Kolan, J.A. Semon, B.A. Bromet B, D.E. Day, and M. Leu. Bioprinting with human stem cells-laden alginate-gelatine and bioactive glass for tissue engineering. IJB, 5(2.2):3-15 (2019)

K.C.R. Kolan, J. Li, S. Roberts, J.A. Semon, J. Park, D.E. Day, and M. Leu. Near-field elecrospinning of a polymer/bioactive glass composition to fabricate 3D biomimetric structures. IJB, 5(1):1-6 (2019)

K.C.R. Kolan, J. Li, S. Roberts, J.A. Semon, J. Park, D.E. Day, M. Leu. Near-field electrospinning of a polymer/bioactive glass composite to fabricate 3D biomimetic structures. IJB, 5(1):1-6 (2018)

C. Murphy, K.C.R. Kolan, M. Long, W. Li, M.C. Leu, J.A. Semon, D.E. Day. 3D Bioprinting of Stem Cells and Polymer/Bioactive Glass Composite Scaffolds for Bone Tissue Engineering. IJB, 3(1):1-11 (2017)

K. Kolan, Y. Liu, J. Baldridge, C. Murphy, J.A. Semon, D.E. Day, M. Leu, A. Shih, J. Cao. Solvent Based 3D Printing of Biopolymer/Bioactive Glass Composite and Hydrogel for Tissue Engineering Applications. 65:38-43. ELSEVIER SCIENCE BV (2017)

C. Murphy, K.C.R. Kolan, M. Long, W. Li, M.C. Leu, J.A. Semon, D.E. Day. 3D Printing of a Polymer Bioactive Glass Composite for Bone Repair. Solid Freeform Fabrication Proceedings, 1718-1731 (2016)

For a complete list of publications, please click any of the following links:

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Scholar's Mine Scopus