Publications

See below for publications related to the current focus of the GRACE Lab. For a complete list of publications by Dr. Ryman, see her Bibliography at the National Library of Medicine or Google Scholar.

Featured Publications

Erhardt, E.B., Mayer, A.R., Lin, H.C., Pirio Richardson, S.E., Shaff, N.A., Vakhtin, A.A., Caprihan, A., van der Horn, H.J., Hoffman, N., Phillips, J.P., Grigg-Damberger, M., Wang, C., Gough, J., Hobson, S., Deligtisch, A., Suarez Cedeno, G., Sugar, D., & Ryman, S.G. (2025). The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults. npj Parkinsons Dis. 11, 334 (2025). https://doi.org/10.1038/s41531-025-01179-6

Ryman, S. G., Vakhtin, A. A., Mayer, A. R., van der Horn, H. J., Shaff, N. A., Nitschke, S. R., Julio, K. R., Tarawneh, R. M., Rosenberg, G. A., Diaz, S. V., Pirio Richardson, S. E., & Lin, H. C. (2024). Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases. Movement Disorders, 39(8), 1258–1268. PDF

Ryman, S. G., Shaff, N., Dodd, A., Nitschke, S., Wertz, C., Julio, K., Suarez Cedeno, G., Deligtisch, A., Erhardt, E., Lin, H., Vakhtin, A., Poston, K. L., Tarawneh, R., Pirio Richardson, S., & Mayer, A. (2023). Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson’s Disease. Movement Disorders. PDF

Ryman, S., Vakhtin, A.A., Richardson, S.P. et al. Microbiome–gut–brain dysfunction in prodromal and symptomatic Lewy body diseases. Journal of Neurology 270, 746–758 (2023). Open Access

2026 (select publications)

Ryman, S., Edwards, K., Ginossar, T., Verney, S., Cheromiah, A., Meehan, T., Nez, M., Garcia, M., Shaff, N., Hoffman, N., Prestopnik, J., Rosenberg, G., Shah, V., & Rahman-Filipiak, A. (2026). Considerations for disclosing Alzheimer's disease risk and biomarker results in a Pueblo community in Southwest United States. Alzheimer's & dementia (Amsterdam, Netherlands), 18(1), e70250. https://doi.org/10.1002/dad2.70250

2025 (select publications)

Vakhtin, A. A., Lin, H. C., Pirio Richardson, S. E., Shaff, N. A., & Ryman, S. G. (2025). Harnessing brain rhythms to activate the glymphatic pathway via controlled breathing and intermittent CO2. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X251399120. Advance online publication. https://doi.org/10.1177/0271678X251399120

Julio, K., van der Horn, H.J., Ryman, S.G. (2025). Fluid and Imaging Markers of Lewy Body Dementias. In: Tarawneh, R. (eds) Biomarkers of Neurodegenerative Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-80849-4_10

Aleksandr Birg, Amanda Carroll-Portillo, Henry C. Lin, Sephira Ryman, Haley Prather, Andrei Vakhtin, Su1281: BACTERIA-DERIVED HYDROGEN SULFIDE IMPROVES ENDOTOXIN LEVELS IN LONG COVID., Gastroenterology, Volume 169, Issue 1, Supplement, 2025, Pages S-729-S-730, ISSN 0016-5085, https://doi.org/10.1016/S0016-5085(25)02629-0 (https://www.sciencedirect.com/science/article/pii/S0016508525026290)

Ryman, S. G., Verney, S. P., Quam, M., Ghahate, D., Prestopnik, J., Partridge, E., Adair, J., Abrams-Silva, L., Knoefel, J., Pankratz, V. S., Erhardt, E., Unruh, M., Rosenberg, G., & Shah, V. (2025). Language Dominance and Education Considerations in the Neuropsychological Assessment of Southwestern American Indians Using the National Alzheimer Coordinating Center's Uniform Data Set Version 3. Alzheimer disease and associated disorders, 39(2), 75–81. https://doi.org/10.1097/WAD.0000000000000668

Lee, B., Young, C. B., Cai, W., Yuan, R., Ryman, S., Kim, J., Yang, L., Henderson, V. W., Poston, K. L., & Menon, V. (2025). Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease. Nature communications, 16(1), 2433. https://doi.org/10.1038/s41467-025-56660-w

van der Horn, H. J., Wick, T. V., Ling, J. M., McQuaid, J. R., Nathaniel, U., Miller, S. D., Kumar, D. S., Zotev, V., Vakhtin, A. A., Ryman, S. G., Cabral, J., Phillips, J. P., Campbell, R. A., Sapien, R. E., & Mayer, A. R. (2025). Trajectories of intrinsic connectivity one year post pediatric mild traumatic brain injury: Neural injury superimposed on neurodevelopment. Cortex; a journal devoted to the study of the nervous system and behavior, 184, 120–130. https://doi.org/10.1016/j.cortex.2024.12.022

Vincent Clark, Benjamin Gibson, Mason Briggs, Jeremy Hogevenn, Chris Wertz, Adam J. Woods Woods, John Phillips, Sephira Ryman, Andrew Mayer, TDCS Reverses Learning Deficits in Mild Cognitive Impairment: Results of the MEMORI Study, a Randomized Double Blind Clinical Trial, Brain Stimulation, Volume 18, Issue 1, 2025, Pages 603-604, ISSN 1935-861X, https://doi.org/10.1016/j.brs.2024.12.1127 (https://www.sciencedirect.com/science/article/pii/S1935861X24013226)

Erhardt, E.B., Mayer, A.R., Lin, H.C., Pirio Richardson, S.E., Shaff, N.A., Vakhtin, A.A., Caprihan, A., van der Horn, H.J., Hoffman, N., Phillips, J.P., Grigg-Damberger, M., Wang, C., Gough, J., Hobson, S., Deligtisch, A., Suarez Cedeno, G., Sugar, D., & Ryman, S.G. (2025). The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults. npj Parkinsons Dis. 11, 334 (2025). https://doi.org/10.1038/s41531-025-01179-6

2024 (select publications)

Ryman, S. G., Vakhtin, A. A., Mayer, A. R., van der Horn, H. J., Shaff, N. A., Nitschke, S. R., Julio, K. R., Tarawneh, R. M., Rosenberg, G. A., Diaz, S. V., Pirio Richardson, S. E., & Lin, H. C. (2024). Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases. Movement Disorders, 39(8), 1258–1268. https://doi.org/10.1002/mds.29867

Aleksandr Birg, van, Ryman, S. G., Branzoli, F., Deelchand, D. K., Quinn, D. K., Mayer, A. R., Lin, H. C., Erhardt, E. B., Arvind Caprihan, Vadim Zotev, Parada, A. N., Wick, T. V., Matos, Y. L., Barnhart, K. A., Nitschke, S. R., Shaff, N. A., Julio, K. R., Prather, H. E., & Vakhtin, A. A. (2024). Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study. Brain Behavior and Immunity. https://doi.org/10.1016/j.bbi.2024.08.034

Hergert, D. C., Gaasedelen, O., Ryman, S. G., Prestopnik, J., Arvind Caprihan, & Rosenberg, G. A. (2024). Blood–Brain Barrier Permeability Is Associated With Cognitive Functioning in Normal Aging and Neurodegenerative Diseases. Journal of the American Heart Association, 13(14). https://doi.org/10.1161/jaha.124.034225

Rutledge, J., Lehallier, B., Zarifkar, P., Moran Losada, P., Shahid-Besanti, M., Western, D., Gorijala, P., Ryman, S., Yutsis, M., Deutsch, G. K., Mormino, E., Trelle, A., Wagner, A. D., Kerchner, G. A., Tian, L., Cruchaga, C., Henderson, V. W., Montine, T. J., Borghammer, P., & Wyss-Coray, T. (2024). Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease. Acta Neuropathologica, 147(1). https://doi.org/10.1007/s00401-024-02706-0

Cai, W., Young, C. B., Yuan, R., Lee, B., Ryman, S., Kim, J., Yang, L., Levine, T. F., Henderson, V. W., Poston, K. L., & Menon, V. (2024). Subthalamic nucleus–language network connectivity predicts dopaminergic modulation of speech function in Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America, 121(22). https://doi.org/10.1073/pnas.2316149121

van der Horn, H. J., Vakhtin, A. A., Julio, K., Nitschke, S., Shaff, N., Dodd, A. B., Erhardt, E., Phillips, J. P., Pirio Richardson, S., Deligtisch, A., Stewart, M., Suarez Cedeno, G., Meles, S. K., Mayer, A. R., & Ryman, S. G. (2024). Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study. Journal of Cerebral Blood Flow & Metabolism, 44(10), 1774–1786. https://doi.org/10.1177/0271678x241241895

Shaff, N., Erhardt, E., Nitschke, S., Julio, K., Wertz, C., Vakhtin, A., Caprihan, A., Suarez‐Cedeno, G., Deligtisch, A., Richardson, S. P., Mayer, A. R., & Ryman, S. G. (2023). Comparison of automated and manual quantification methods for neuromelanin‐sensitive MRI in Parkinson’s disease. Human Brain Mapping, 45(1). https://doi.org/10.1002/hbm.26544

2023 (select publications)

Ryman, S. G., Shaff, N., Dodd, A., Nitschke, S., Wertz, C., Julio, K., Suarez Cedeno, G., Deligtisch, A., Erhardt, E., Lin, H., Vakhtin, A., Poston, K. L., Tarawneh, R., Pirio Richardson, S., & Mayer, A. (2023). Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson’s Disease. Movement Disorders. https://doi.org/10.1002/mds.29429

Ryman, S., Vakhtin, A.A., Richardson, S.P. et al. Microbiome–gut–brain dysfunction in prodromal and symptomatic Lewy body diseases. Journal of Neurology 270, 746–758 (2023). https://doi.org/10.1007/s00415-022-11461-9

Shahid, M., Rawls, A., Ramirez, V., Ryman, S., Santini, V. E., Yang, L., Sha, S. J., Hall, J. N., Montine, T. J., Lin, A., Tian, L., Henderson, V. W., Cholerton, B., Yutsis, M., & Poston, K. L. (2023). Illusory Responses across the Lewy Body Disease Spectrum. Annals of Neurology, 93(4), 702–714. https://doi.org/10.1002/ana.26574

Erhardt, E., Horner, A., Shaff, N., Wertz, C., Nitschke, S., Vakhtin, A., Mayer, A., Adair, J., Knoefel, J., Rosenberg, G., Poston, K., Suarez Cedeno, G., Deligtisch, A., Pirio Richardson, S., & Ryman, S. (2023). Longitudinal hippocampal subfields, CSF biomarkers, and cognition in patients with Parkinson disease. Clinical parkinsonism & related disorders, 9, 100199. https://doi.org/10.1016/j.prdoa.2023.100199

2022 (select publications)

Ryman, S. G., Caprihan, A., Rosenberg, G., Prestopnik, J., Quam, M., Ghahate, D., Pankratz, V. S., Faber, T., Unruh, M., & Shah, V. (2022). Albuminuria, cognition, and MRI biomarkers of cerebrovascular disease in American Indians of the Zuni Pueblo. eNeurologicalSci, 29, 100438. https://doi.org/10.1016/j.ensci.2022.100438

Shahid, M., Rawls, A., Ramirez, V., Ryman, S., Santini, V.E., Yang, L., Sha, S., Hall, J.N., Montine, T.J., Lin, A., Henderson, V., Cholerton, B., Yutsis, M. and Poston, K.L. (2022), Illusory responses across the Alzheimer’s disease spectrum and Lewy body disease spectrum. Alzheimer's & Dementia, 18: e063733. https://doi.org/10.1002/alz.063733

Cai, W., Young, C. B., Yuan, R., Lee, B., Ryman, S., Kim, J., Yang, L., Henderson, V. W., Poston, K. L., & Menon, V. (2022). Dopaminergic medication normalizes aberrant cognitive control circuit signalling in Parkinson’s disease. Brain, 145(11). https://doi.org/10.1093/brain/awac007

Cavanagh, J. F., Ryman, S., & Richardson, S. P. (2022). Cognitive control in Parkinson’s disease. Progress in Brain Research, 269(1), 137–152. https://doi.org/10.1016/bs.pbr.2022.01.019

Miller, J., Jones, T., Upston, J., Deng, Z.-D., McClintock, S. M., Ryman, S., Quinn, D., & Abbott, C. C. (2021). Ictal Theta Power as an Electroconvulsive Therapy Safety Biomarker. Journal of Ect, 38(2), 88–94. https://doi.org/10.1097/yct.0000000000000812

Lee, B., Cai, W., Young, C. B., Yuan, R., Ryman, S., Kim, J., Santini, V., Henderson, V. W., Poston, K. L., & Menon, V. (2022). Latent brain state dynamics and cognitive flexibility in older adults. Progress in Neurobiology, 208, 102180. https://doi.org/10.1016/j.pneurobio.2021.102180

Rutledge, J., Lehallier, B., Zarifkar, P., Losada, P. M., Ryman, S., Yutsis, M., Deutsch, G., Mormino, E., Trelle, A., Wagner, A. D., Kerchner, G., Tian, L., Henderson, V. W., Montine, T. J., Per Borghammer, Wyss-Coray, T., & Poston, K. L. (2022). Aromatic L-Amino Acid Decarboxylase is a novel fluid biomarker of Parkinson’s disease. MedRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2022.11.09.22282149 (Preprint)