What is the purpose of the study?

The purpose of this study is to evaluate the effectiveness of fructooligosaccharides (FOS) supplementation in improving the gut health of underprivileged older adults in Malaysia by examining changes in their gut microbiome and metabolic activity.

Why is this study important?

This study is important because most Malaysian adults, especially older adults with low socioeconomic status, consume inadequate dietary fibre — which is crucial for gut health, nutrient absorption, and prevention of chronic diseases, muscle loss, and cognitive decline. The findings could support strategies to improve gut health and overall well-being among a vulnerable population.

What type of study is this?

This is a longitudinal interventional study in which older adults receive a prebiotic (FOS) supplement, and their gut microbiome and metabolism are assessed at multiple time points to track changes.

How long will I be involved in this study?

You will be involved for about 8–10 weeks, during which FOS sachets will be distributed at several time points (week 0, 2, 4, 6, 8, and 10), and stool and urine samples will be collected at week 0, week 4, and week 8.

What will happen to any samples I give?

The samples you provide will be used only for this study. They will be securely stored and may be analyzed for related research in the future in compliance with ethical and regulatory guidelines. Specimens will be processed at Monash University Malaysia. Unprocessed samples will be securely stored at -80°C at the earliest opportunity. All specimens and data will be handled in compliance with ethical and regulatory guidelines, ensuring the utmost confidentiality and security.

At the end of the study, any remaining samples may be retained for future research for seven (7) years, subject to your consent. Specimens no longer required will be destroyed following institutional policies to ensure proper disposal.

Will my medical information be kept private?

All information obtained in the study will be kept and handled in a confidential manner, in accordance with applicable laws and/or regulations. This study has been approved by the Monash University Human Research Ethics Committee (MUHREC) [Project ID: 46148]. Only researchers involved in this study will access your data while your study data will be securely stored in password protected spreadsheets. Deidentified data may be shared on the ROBOT platform and DNA sequencing data deposited in GenBank for research purposes. When publishing or presenting the study results, your identity will not be revealed without your expressed consent. 

Will I be informed of the study findings?

The overall study results will not be informed to you. However, it may be available in the form of journal publication.

Who should I contact if I have questions?

If you have any questions about the study, you may contact Associate Professor Dr Chong Chun Wie (ChongChunWie@monash.edu) for further information.