Leave your comments here

International Credentials

International recognition

Topic Editors

for special issues

Novel Approaches to The Treatment of Multidrug-Resistant BacteriaMultidrug-resistant (MDR) organisms are one of the key global problems faced by healthcare providers; where MDR superbugs used to be limited to hospital-acquired infection, they are now reported in community-acquired infections. This creates a dilemma as more potent antimicrobials need to be considered as first-line treatment, which in turn generates greater drug resistance. Treatment failure of bacterial infections has become more common as organisms that were once susceptible to the majority of clinically used antibiotics have developed resistance, resulting in greater morbidity and mortality rates.Current research shows that there is a rising incidence of multidrug resistance among a wide variety of human pathogens. There is a myriad of mechanisms of resistance that can be observed, including altered targets of antimicrobial drugs (be they structural proteins or enzymes), and reduction of drug concentrations in the target organism by reducing entry or by active efflux, where the chromosomal coding to enable these are often transmitted from other bacteria via plasmids. Several researchers have warned that we may be headed back to the pre-antibiotic era if no solutions are found for the increasing trend of MDR organisms. Several research avenues have been suggested to combat this including combinations of existing antibiotics or using adjuvants in combination with antibiotics to overcome the resistance, and of course looking for new antibiotics or alternative treatments s...

Novel Approaches to The Treatment of Multidrug-Resistant Bacteria, volume IIMultidrug-resistant (MDR) organisms are one of the key global problems faced by healthcare providers; where MDR superbugs used to be limited to hospital-acquired infection, they are now reported in community-acquired infections. This creates a dilemma as more potent antimicrobials need to be considered as first-line treatment, which in turn generates greater drug resistance. Treatment failure of bacterial infections has become more common as organisms that were once susceptible to the majority of clinically used antibiotics have developed resistance, resulting in greater morbidity and mortality rates.Current research shows that there is a rising incidence of multidrug resistance among a wide variety of human pathogens. There is a myriad of mechanisms of resistance that can be observed, including altered targets of antimicrobial drugs (be they structural proteins or enzymes), and reduction of drug concentrations in the target organism by reducing entry or by active efflux, where the chromosomal coding to enable these are often transmitted from other bacteria via plasmids. Several researchers have warned that we may be headed back to the pre-antibiotic era if no solutions are found for the increasing trend of MDR organisms. Several research avenues have been suggested to combat this including combinations of existing antibiotics or using adjuvants in combination with antibiotics to overcome the resistance, and of course, looking for new antibiotics or alternative treatments ...

Actinobacteria: Prolific Producers of Bioactive Metabolites Natural products continue to be an indispensable source of leads for new medicines in order to fulfill the burgeoning market demand. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread emergence of antimicrobial-resistant pathogens, and coinciding with the reduced number of new drugs in the market, have driven this field of research further by looking at all potential sources of natural products. The concept of drug discovery from microbial sources have made significant contributions to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers and highly pertinent in face of today’s booming resistance and health issues. Actinobacteria are one of the most prominent and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds. In fact, they have provided more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by r...

The search for biological active agent(s) from actinobacteriaThere is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The fur...

Media coverage

MUGA .pdf

Natural means to combat AHPND in Malaysia’s shrimp farming sectorProducts derived from two native plants could significantly improve the sustainability of Malaysia’s shrimp and prawn farming sector, according to researchers from Monash University.

Salvaging Malaysia’s shrimp industry reputationMalaysia’s shrimp industry is big business, but unapproved antibiotic use has led to negative perceptions of the country’s aquaculture industry. Can bioprospecting turn things around?

Ilmuwan Kembangkan Probiotik dari Habitat Asli UdangBerita Perikanan - Peneliti berharap dapat mengubah galur probiotik yang diisolasi dari hutan bakau menjadi agen biokontrol untuk budidaya udang.

International recognition by senior expert in the field

In memory of Eugene WeinbergIn memory of IU Professor Emeritus Eugene D. Weinberg, 1922-2019.

Statement received from the late Professor Emeritus E.D. Weinberg from Indiana University, US

Dear Dr. Bey-Hing Goh,

Just a brief note to express my enthusiasm for your fine review on Streptomyces bacteria as potential probiotics in aquaculture in Front Microbiol 2016.

“This fine article in a first rate journal articulates potential roles of Streptomyces which tends to be overlooked by many research scientists. Your work demonstrates a maturity of understanding in this field and reflects in depth mechanisms that might be involved. This article will not only create an immediate impact but also will stimulate further discoveries of the usefulness of Streptomyces to our civilization.”

E.D. Weinberg, PhD, 2016

Navigate

Page updated

Report abuse