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Arushi Agrawal and Dean Castillo
Department of Biology, Miami University, Oxford OH
Abstract
Abstract
The evolution of sex chromosomes influences reproductive biology and genome evolution across species. In Drosophila pseudoobscura, the Y chromosome has a distinct origin compared to Drosophila melanogaster, with some ancestral Y-linked fertility genes now located on autosomes. Additionally, the Y chromosome exhibits polymorphism due to differences in transposable elements, raising questions about its role in male reproductive traits. This study investigates whether males with different Y chromosome genotypes exhibit fertility differences, measured as progeny production. Using carefully controlled fertility assays, virgin males and females were paired, and offspring were counted over a specified period.
Research Objectives
Research Objectives
Determine whether natural variation in Y chromosome size and structure influences male fertility and reproductive success in Drosophila pseudoobscura.
Establish Y chromosome substitution lines to isolate Y-linked effects from autosomal and X-linked genetic background, allowing for future gene expression and functional analyses.
Student Researcher
Student Researcher
Arushi Agrawal '27
Spanish Major | Premedical Co-Major
Faculty Advisor
Faculty Advisor
Dr. Dean Castillo
Assistant Professor.
Department of Biological Sciences, Miami University.
Acknowledgement
Acknowledgement
I’m incredibly grateful to Dr. Castillo for his guidance, support, and encouragement throughout this project. His mentorship has been invaluable in shaping my research experience and helping me grow as a researcher.
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