Awareness and education are two of the best defenses against substance misuse and overdose. In Virginia, drug overdoses are the leading cause of unnatural death and have been since 2013. More Virginians die every year from overdoses than from automobile crashes. Opioids - specifically fentanyl - has been the driving force behind the large increases. Parents and caregivers are the first line of defense in protecting their child against substance use and overdose. Â