About Dr. Sean McBride

Dr. Sean McBride is excited to provide clinical care in his new private practice and continue to conduct basic science research through his newly founded Institute for Brain and Behavioral Health. He has over 30 years of experience studying the molecular underpinnings and circuitry of learning, memory and attention across multiple animal models. He brings his extensive scientific training and knowledge to translate breakthrough research findings to help patients with a variety of psychiatric needs.

EDUCATION & TRAINING

Dr. McBride grew up in Cape May, N.J. He received his undergraduate degree in biology from Swarthmore College and his M.D. and Ph.D. degrees from the Albert Einstein College of Medicine in Bronx, N.Y., where he completed the prestigious NIH-sponsored dual-degree Medical Scientist Training Program. He then received his psychiatry training at the University of Pennsylvania Health System and Penn Behavioral Health with sub-specialty training at the Penn Memory Center and in the Penn Adult ADHD and Developmental Disorders Program. After his residency, Dr. McBride completed a clinical fellowship and a basic science fellowship in Neuropsychopharmacology also at the University of Pennsylvania.

PRIOR ACADEMIC APPOINTMENT

Assistant Professor, Rowan University School of Osteopathic Medicine in the Departments of Cell Biology, Geriatrics and Gerontology, Psychiatry and the New Jersey Institute for Successful Aging

SELECT SCIENTIFIC TALKS BY INVITATION

National Fragile X Foundation International Conference, Cincinnati, OH. "From flies to mice to clinic, a story of discovery", July, 2018.

Senior Biology and Campus wide Seminar, Swarthmore College. Swarthmore, PA. "Enhancing memory in monogenetic disorders associated with intellectual disability and autism spectrum disorders", September, 2018

Winter Conference on Brain Research. "Enhancing memory in Fragile X fly and mouse models", February, 2019.

NJISA Fellows Research Conference. "Enhancing memory in animal models of Alzheimer's disease", Spring, 2019.

National Fragile X Foundation International Conference, Held Virtually. "Using medications for diabetes in the treatment of Fragile X syndrome to improve social interactions, language and anxiety", July, 2020.

NIA (National Institute on Aging)-NIH Workshop: Can Autism tell us Anything about Alzheimer’s Disease. "Identifying novel molecules for the treatment of ASDs and Alzheimer’s Disease", March, 2022.

HIGHLIGHTS OF PUBLICATIONS

1. Rachel Monyak, Danielle Emerson*, Brian P. Schoenfeld*, Xiangzhong Zheng, Daniel B Chambers, Paul Hinchey, Catherine H. Choi, Thomas V. McDonald, Francois V. Bolduc, Amita Sehgal, Sean M. J. McBride# and Thomas A. Jongens#. “Insulin Misregulation underlies Circadian and Cognitive Deficits in a Drosophila Fragile X Model.” (2017) Molecular Psychaitry. Apr 19. doi: 10.1038/mp.2016.51. [Epub ahead of print 2016]. #Co-corresponding authors.

2. Catherine H. Choi, Brian P. Schoenfeld, Aaron J. Bell, Joseph Hinchey, Daniel B. Chambers, Michael J. Gertner, Sean R Campbell, Danielle Emerson, Paul Hinchey, Maria Kollaros, Neal J. Ferrick, Cory Rosenfelt, Steven Langer, Steven Sust, Aatika Malik, Allison M. Terlizzi, David A. Liebelt, David Ferreiro, Ali Sharma, Eric Koenigsberg, Richard J. Choi, Natalia Louneva, Steven E. Arnold, Robert E. Featherstone, Steve J. Siegel, R Suzanne Zukin, Francois Bolduc#, Tom V. McDonald#, Thomas A. Jongens#, Sean M. J. McBride# “Multiple drug treatments that increase cAMP signaling restore long-term memory and aberrant signaling in fragile X syndrome models.” (2016) Frontiers in Behavioral Neuroscience. Jun 30;10:136. doi: 10.3389/fnbeh.2016.00136. eCollection 2016. #Co-corresponding authors.

3. Catherine Choi, Brian Schoenfeld, Eliana Weisz, Aaron Bell, Daniel Chambers, Joseph Hinchey, Richard Choi, Paul Hinchey, Maria Kallaros, Michael Gertner, Neal Ferrick, Allison Terlizzi, Nicole Yohn, David Liebelt, Eric Koenigsberg, R. Suzanne Zukin, Newton Woo, Michael Tranfaglia, Natalia Louneva, Steven Arnold, Steven Siegel, #Francois Bolduc, #Thomas McDonald, #Thomas Jongens, and #Sean McBride. “PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of Fragile X syndrome.” (2015) Journal of Neuroscience. Jan 7;35(1):396-408. doi: 10.1523/JNEUROSCI.1356-12.2015. #Co-corresponding authors.

4. Marc A. Wolman, Eric D. de Groh, Sean M. McBride, Thomas A. Jongens, Michael Granato and Jonathan A. Epstein.“Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1.” (2014) Cell Reports. Sep 11;8(5):1265-70. doi: 10.1016/j.celrep.2014.07.054. Epub 2014 Aug 28.

5. Brian P. Schoenfeld, Richard J. Choi, Catherine H. Choi, Aaron J. Bell, Paul Hinchey, Maria Kollaros, Neal J. Ferrick, Allison M. Terlizzi, David A. Liebelt, David Ferreiro, Steven J. Siegel, Thomas V. McDonald#, Thomas A. Jongens#, Sean M. J. McBride#. “The Drosophila DmGluRA is required for social interaction and memory” (2013) Frontiers in Pharmacology. May 23;4:64. #Co-corresponding authors.

6. Catherine H. Choi, Brian P. Schoenfeld, Aaron J. Bell, Paul Hinchey, Maria Kollaros, Michael J. Gertner, Newton H. Woo, Michael R. Tranfaglia, Mark F. Bear, R. Suzanne Zukin, Thomas V. McDonald, #Thomas A. Jongens, #Sean M. J. McBride.“Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment.” (2011) Brain Research., Mar 22;1380:106-19. #Co-corresponding authors.

7. *#McBride, S.M.J., *Choi, C.H., *Schoenfeld, B.P., Bell, A., Rudominer, R.L., Liebelt, D.A., Ferreiro, D., Choi, R.J., Terlizzi, A.M., Ferrick, N.J., Koenigsberg, E., Hinchey, P., Kollaros, M,. Sumida, A., Chiorean, S., Siwicki, K.K., Nguyen, H.T., Fortini, M.E., #McDonald, T.V., #Jongens, T.A. "Pharmacological and genetic reversal of age dependent cognitive deficits due to decreased presenilin function." (2010) Journal of Neuroscience, Jul 14;30(28):9510-22. *Authors contributed equally. #Co-corresponding authors.

8. Banerjee, P., Schoenfeld, B.P., Bell, A.J., Choi, C.H., Bradley, M.P., Hinchey, P., Kollaros, M., Park, J.H., #McBride, S.M.J., #Dockendorff, T.C. "Short and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein." (2010) Journal of Neuroscience, May 12;30(19):6782-92. #Co-corresponding authors.

9. *Choi, C.H., *#McBride, S.M., Schoenfeld, B.P., Liebelt, D.A., Ferreiro, D., Ferrick, N.J., Hinchey, P., Kollaros, M., Rudominer, R.L., Terlizzi, A.M., Koenigsberg, E., Wang, Y., Sumida, A., Nguyen, H.T., Bell, A.J., McDonald, T.V., #Jongens, T.A. (2010) "Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue." (2010) Biogerontology., Jun;11(3):347-62. *Authors contributed equally. #Co-corresponding authors.

10. Sharma, A., Hoeffer, C.A., Takayasu, Y., Miyawaki, T., **McBride, S.M., **Klann, E., Zukin, R.S. (2010) Dysregulation of mTOR signaling in fragile X syndrome. *Authors contributed equally. J of Neuroscience, 30: 694-702.

11. *#McBride, S. M., *Choi, C. H., Wang, Y., Liebelt, D., Braunstein, E., Ferreiro, D., Sehgal, A., Dockendorff, T. C., Nguyen, H., McDonald, T. V., and #Jongens, T. A. (2005) “Pharmacological rescue of synaptic plasticity, courtship behavior and mushroom body defects in a Drosophila model of Fragile X syndrome.” Neuron, 45: 753-64. *Authors contributed equally. #Co-corresponding authors.

12. Dockendorff, T. C., **Su, H. S., **McBride, S. M., Yang, Z., Choi, C. H., Siwicki, K. K., Sehgal, A., and Jongens T. A. (2002) “Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.” Neuron, 34: 973-84. **Authors contributed equally.

13. McBride, S. M. J., Giuliani, G., Choi, C., Correale, D., Watson, K., Krause, P., Baker, G., and Siwicki, K. K. (1999) “Mushroom body ablation impairs short-term memory and long-term memory of courtship conditioning in Drosophila melanogaster.” Neuron, 24: 967-77.

14. Mak, D. D., McBride, S. and Foskett, J. K. (1998) “ Inositol 1, 4, 5-trisphosphate activation of inositol trisphosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.” Proc. Natl. Acad. Sci., U. S. A., 95: 15,821-5.

MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES (past and present)

• American Psychiatric Association

• American Academy of Psychodynamic Psychiatry and Psychoanalysis

• Neuropsychoanalysis Association

• New Jersey Psychiatric Society

• Society for Neuroscience

• American Medical Association

• FRAXA Research Foundation

• National Fragile X Foundation

• CHARGE Syndrome Foundation

• Society of General Physiology

• Biophysical Society

For Dr. McBride's complete CV, please click here (Google users): Curriculum Vitae