My Internship

Overview of Internship Research Mission

Exposure to drugs during pregnancy influences serious conditions and mortality among newborns, infants, and developing pediatrics patients. In utero drug exposure can cause the fetus to become vulnerable to teratogenic effects, death, inadequate growth, premature or fetal distress during labor depending on the substance abused. Following birth, the newborn may experience respiratory distress, low birth weight, and withdrawal symptoms (tremors/irritability, sleep problems, high pitched crying, tight muscle tone, hyperactive reflexes, seizures, poor feeding, vomiting, diarrhea, dehydration, sweating, unstable temperature, etc). While these immediate effects can determine the length of stay in the NICU, there is a significant potential for long term effects on physical, mental, behavioral development and ability to reach normative scoring and milestones. Since many studies have confirmed the negative impact among pediatric patients secondary to illicit substance use, it is extremely important to assess the outcomes of Intrauterine drug exposure and opioid maintenance during pregnancy. My research with Neonatologist Dr. Matory focuses on the observational study conducted between 2002 and 2009 of pregnant women receiving buprenorphine and methadone opioid maintenance therapy treatments at Wishard Memorial Hospital in Indianapolis, IN. This data followed the journey of 79 pregnant women all of whom received their prenatal care at the outpatient substance abuse clinic at Wishard Memorial Hospital. The principle of this data consisted of data regarding the newborns included the type of delivery, gestation, birthweight, maternal admission drug screen, newborn urine and meconium drug screens, Apgar testing scores at 1 and 5 minutes following birth, newborn length of stay and treatment for Neonatal Abstinence Syndrome. The children within this study are now between the ages of 8 and 15 and received follow up visits at Eskenazi Health. Our mission is to retrospectively observe the medical records of the long-term outcomes of those infants that unfortunately experienced in utero drug exposure to the most commonly prescribed opioid treatments, buprenorphine and methadone in order to evaluate developmental and behavioral outcomes, medical issues, resource utilization, and routine well visits in the first 3-5 years of the newborn's life. In prospect, the hypothesis follows the belief that women who received the opioid treatments of methadone and buprenorphine will illustrate increased numbers of health care provider and medical interventions and lower successful pediatric patient assessments compared to normative and acceptable scoring with aging.

Limitations Of Observational Study

Of the expected data consisting of 418 total moms delivered- 79 of those mothers received either methadone or buprenorphine opioid therapy treatment prior to delivery and some limitations imposed upon the research regarding continued participation of the families if multiple health clinics and physicians are involved. In order to ensure the results and completion of necessary testing and evaluations for follow up outpatient visits- it is essential that the patients begins and ends with the same identified provider who monitors the development of the child. Several of the infants within the newborn nursery and NICU were provided with discharge and follow up appointments with primary care physicians in the healthcare system (Eskenazi formerly known as Wishard). It is expected that a majority of the patients remained within the clinics for the first 1-5 years of the child's life. Review of follow up information could provide a foundation for emerging and ongoing developmental problems. Unfortunately to date it was confirmed that there was quite a bit of data is missing particularly the older the children become, supporting the prediction that they did not continue care through the represented health systems, that they did not receive annual physics, and that child notes are not as frequent as expected. We will continue to review charting for these patients and cross reference information with subspeciality and developmental clinics.

Journals That Represent Research Similar To Our Mission

Morphine vs methadone in the treatment of neonatal abstinence syndrome

Cooney, Hannah, Hodgson, Kate & Davis, Peter. (2019). Morphine vs methadone in the treatment of neonatal abstinence syndrome. Acta Paediatrica, https://doi.org/10.1111/apa.14846

Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome

Lemon, Lara, Caritis, Steve, Venkataramanan, Raman, Platt, Robert & Bodnar, Lisa. (2018). Methadone Versus Buprenorphine for Opioid Use Dependence and Risk of Neonatal Abstinence Syndrome. Epidemiology, 29, 261-268. https://doi.org/10.1097/EDE.0000000000000780

Prenatal Buprenorphine Versus Methadone Exposure and Neonatal Outcomes: Systematic Review and Meta-Analysis


Brogly, Susan, Saia, Kelley, Walley, Alexander, Du, Haomo & Sebastiani, Paola. (2014). Prenatal Buprenorphine Versus Methadone Exposure and Neonatal Outcomes: Systematic Review and Meta-Analysis. American Journal of Epidemiology, 180, 673-686. https://doi.org/10.1093/aje/kwu190






High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome

Lim, Susie, Prasad, Mona, DO, MPH, Samuels, Philip, Gardner, Debra & Cordero, Leandro. (2009). High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. American Journal of Obstetrics & Gynecology, 200(1), 70e1-70e5. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovftj&NEWS=N&AN=00000447-200901000-00019.


Pharmacological Management of Opioid Use Disorder in Pregnant Women

Lim, Susie, Prasad, Mona, DO, MPH, Samuels, Philip, Gardner, Debra & Cordero, Leandro. (2009). High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. American Journal of Obstetrics & Gynecology, 200(1), 70e1-70e5. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovftj&NEWS=N&AN=00000447-200901000-00019.

Buprenorphine for the Treatment of Opioid Dependence in Pregnancy

Mittal, Leena. (2014). Buprenorphine for the Treatment of Opioid Dependence in Pregnancy. Journal of Perinatal & Neonatal Nursing, 28, 178-184. https://doi.org/10.1097/JPN.0000000000000044



Buprenorphine compared with methadone in opioid-dependent pregnant women: How does it affect neonatal abstinence syndrome?

Bivin, Bethany, MSN, RN, APRN, PMHNP-BC, Waring, Ashley, MSN, RN, CNP, CPN, et al. (2021). Buprenorphine compared with methadone in opioid-dependent pregnant women: How does it affect neonatal abstinence syndrome?. Journal of the American Association of Nurse Practitioners, 33, 119-125. https://doi.org/10.1097/JXX.0000000000000345

Comparison of Neonatal Abstinence Syndrome Manifestations in Preterm Versus Term Opioid-Exposed Infants

Allocco, Elizabeth, Melker, Marjorie, Rojas-Miguez, Florencia, Bradley, Caitlin, MS, NNP, Hahn, Kristen, et al. (2016). Comparison of Neonatal Abstinence Syndrome Manifestations in Preterm Versus Term Opioid-Exposed Infants. Advances in Neonatal Care, 16, 329-336. https://doi.org/10.1097/ANC.0000000000000320

Methadone and Buprenorphine for Opioid Dependence During Pregnancy: A Retrospective Cohort Study

Meyer, Marjorie, Johnston, Anne, Crocker, Abigail & Heil, Sarah. (2015). Methadone and Buprenorphine for Opioid Dependence During Pregnancy: A Retrospective Cohort Study. Journal of Addiction Medicine, 9, 81-86. https://doi.org/10.1097/ADM.0000000000000092


The Value of this Experience

All the activities that LHSI implemented in the long run expanded my depth of academic knowledge and gave me the ability to connect it to opportunities where I learned professional behaviors, gained leadership, strengthened my independence, built a professional network and assisted a team of medical professionals. Throughout the program I began to understand the significance behind the assignments, meetings, and development of an eportfolio because I was able to reflect upon the values of this amazing opportunity. LHSI helped navigate alongside the internship to amplify the meaningful memories, exceed beyond expectations, and utilize these advantages to develop a well-rounded student. Besides reaching milestones within my career and developing goals I believe that this experience with Dr.Matory broadened my perspectives on child development, neonatal care, and the worldwide effects that the opioid crisis in regards to NAS. Dr. Matory has given me a chance to be apart of developing clinical opioid therapy treatments and answering important questions that research and medicine revolving neonates has to offer. This internship peaked my interest because I wanted the ability to promote infant healthcare and productively become competent in risks associated with NAS in order to help improve child development.

Connections Between Classroom & Internship

The foundation of our research focuses on the idea that Neonatal Abstinence Syndrome proposes premature exposure to drugs which in consequence causes short and long term effects on infants health- physically, mentally, behaviorally. Since my major is Biology with pre-med track many off my classes relate to internship work in a way that supplies essential background information to understand the health risks imposed upon the baby. Throughout my college career I have enrolled in courses and become involved in activities that centralize science and medicine. Hand in hand, I am able to gain another perspective of how NAS works and possible ways to treat it in order to have a deeper understanding.

Meaningful Involvement

The first encounter I had with my supervisors was definitely intimidating because I found it difficult trying to balance professional communication yet also having the ability to be myself, since teamwork is the dreamwork as they say! After meeting them throughout the semester I am pleased to have been matched and accepted into an internship with such profound supervisors. I am able to express my concerns, questions, and ideas since they are always open and responsive, providing feedback when needed which allowed me to build a connection and a lasting impression that will make an impact for future career involvement. Throughout the site visit it strengthened my confidence as an intern when I was given validation that I was right on track and that my supervisor was satisfied with my work to recommend me for other possibilities down the line if I was interested! Having the opportunity to interact with my team whether it is via zoom, email, or in person has been extraordinary given the circumstances of covid- my supervisors have went above and beyond in order to give me an experience in areas I can grow in as a professional. My supervisors are supportive, display a helpful and respectful demeanor, and demonstrate compassion. They understand that even with my commitment and responsibility as an intern I am also a full-time student so while they hold high expectations they also always communicate so we as a team can effectively get the work done with quality along with meeting deadlines. I aspire to embody the professional behaviors and skills they acquire in order to be a successful and dependable professional myself one day.

Internship Reflections/ Favorite Experiences

While many people may reflect on the word "intern" as a person who just runs errands and grabs the coffee, it is so much more than that. As an intern I have become to realize that it is never to early in my career to gain experience and that there is never too much to learn from your supervisors- in fact, they become your role model and personally I embraced everything they threw my way in order to enhance my developmental goals and skills. Working in neonatology gave me newfound knowledge of skills, career paths, and research analysis. Throughout my time, there were multiple occasions I had to step out of my comfort zone in order to gain independence, believe in myself, and feel a sense of accomplishment through my work. In the past I never had much confidence in my communication in regards to speaking up and asking questions to my superiors. However, my supervisors have encouraged me to be a team player and involve me in tasks and projects along with providing constructive criticism and reassurance that my help is appreciated. My team has always been supportive from the beginning and forming professional connections with them has made journey that much better! Building a professional network has been an important aspect of this internship to me and I believe that I have made a lasting impression to be confident within. I have gained an understanding to always work hard no matter what I am doing even if the tasks are large, challenging, or never seem to be perfect which has taught me good work ethic to strive within the world of healthcare.

Success and Challenges

Throughout this opportunity my team and I have experienced many highs and lows together highlighted through our research. Due to covid, limitations of the observation study, and repetitive unfortunate luck of finding documentation of the screenings performed- some things began to look more promising than others. While we were not successful in retrieving everything from the databases I began to independently research literature reviews revolving the mission of our project. While I continue to wait to hear back from Regenstreif I have been fortunate enough to use the IUPUI library databases to my advantage and found many interesting perspectives on neonatal medicine regarding NAS, my abstracts for these journals can be found above. I am hopeful that I will soon be able to compare our data to those performed places around the world which makes this work even more relevant outside the boundaries of LHSI and Indianapolis. I believe that regardless of setback, we were able to overcome these challenges and persevere!


Expectations Vs Reality

My expectations coming into this internship may have been a little unrealistic with the pandemic. While the idea of physically interacting in a healthcare environment and having more data to analyze is appealing- in reality the internship was online and there was major setbacks that me and my team had to adapt to quickly in this forever changing covid-19 world that we live in today. Along with that, it also was difficult to communicate with peers and gain diverse perspectives through an online discussion of zoom breakout rooms. In the beginning, I was skeptical that I would really "gain" the internship involvement that I signed up for. However, in all honestly I would not change this experience for anything, I have learned and grown so much beyond the person I was before this internship. It might sound far-fetched or absurd but working with others during a tough time like this really allows you to display what you are capable of and what you are lacking in regards to motivation with everything being virtual, I'll admit zoom fatigue is a real thing!