Publications

Selected Journal Publications: Link to google scholar

• A computational framework for detecting inter-tissue gene-expression coordination changes with aging

S Briller, G Ben David, Y Amir, G Atzmon, J Somekh

Scientific Reports 2025

*Featured in Globes Health, Jerusalem Post, interview in Kan 11 Television, Kol Israel radio-Kan Tarbut, Radio B.

• Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health. 

    Yi F, Yuan J, Han F, Somekh J, Peleg M, Wu F, Jia Z, Zhu YC, Huang Z.

    Brain 2025

• Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank

  F Yi, J Yuan, J Somekh, M Peleg, YC Zhu, Z Jia, F Wu, Z Huang

   Science Advances 2025

• Machine learning on longitudinal multi-modal data enables the understanding and prognosis of Alzheimer’s disease progression. 

Zhang S, Yuan J, Sun Y, Wu F, Liu Z, Zhai F, Zhang Y, Somekh J, Peleg M, Zhu YC, Huang Z

iScience 2024

• A methodology for classifying tissue-specific metabolic and inflammatory receptor functions applied to subcutaneous and visceral adipose

GA Yehuda, J Somekh

PLOS ONE, 2022.

• Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles

I Shalev, J Somekh, A Eran

Journal of Medical Genetics, 2022.

• Predicting mechanical ventilation effects on six human tissue transcriptomes

J Somekh, N Lotan, E Sussman, GA Yehuda

PLOS ONE, 2022.

• Model-based pathway enrichment analysis applied to the TGF-beta regulation of autophagy in autism

J Somekh

Journal of Biomedical Informatics, 2021.

• A methodology for predicting tissue-specific metabolic roles of receptors applied to subcutaneous adipose

J Somekh

Scientific Reports, 2020.

• Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

J Somekh, SS Shen-Orr, IS Kohane

BMC Bioinformatics, 2019. 

• Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Haberman, Y., Karns, R., Dexheimer, P.J., Schirmer, M., Somekh, J. et al.

Nature communications, 2019.     

• A Model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease

J Somekh, M Peleg, A Eran, I Koren, A Feiglin, A Demishtein, R Shiloh, M Heiner, SW Kong, Z Elazar, and IS Kohane.

Journal of Biomedical Informatics, 2016. 

• Conceptual Modeling of mRNA Decay Provokes Hypotheses 

J Somekh, G Haimovich, A Guterman, D Dori and M Choder

PlOS ONE, 2014. 

• Conceptual Model-Based Systems Biology: Mapping Knowledge and Discovering Gaps in the mRNA Transcription Cycle

J Somekh, M Choder, and D Dori

PLOS ONE, 2012.

• A Methodology for Eliciting and Modeling Exceptions

M Peleg, J Somekh, and D Dori

Journal of Biomedical Informatics, 2009.