Publications

Selected Journal Publications:

• A methodology for classifying tissue-specific metabolic and inflammatory receptor functions applied to subcutaneous and visceral adipose

GA Yehuda, J Somekh

PLOS ONE, 17 (10), e0276699, 2022.

• Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles

I Shalev, J Somekh, A Eran

Journal of Medical Genetics, 59 (10), 1002-1009, 2022.

• Predicting mechanical ventilation effects on six human tissue transcriptomes

J Somekh, N Lotan, E Sussman, GA Yehuda

PLOS ONE, 17 (3), e0264919, 2022.

• Model-based pathway enrichment analysis applied to the TGF-beta regulation of autophagy in autism

J Somekh

Journal of Biomedical Informatics, 103781, 2021.

• A methodology for predicting tissue-specific metabolic roles of receptors applied to subcutaneous adipose

J Somekh

Scientific Reports, 10(1): 1-11, 2020.

• Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

J Somekh, SS Shen-Orr, IS Kohane

BMC Bioinformatics, 20:268, 2019. 

• Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Haberman, Y., Karns, R., Dexheimer, P.J., Schirmer, M., Somekh, J. et al.

Nature communications, 10(1), p.38, 2019.     

• A Model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease

J Somekh, M Peleg, A Eran, I Koren, A Feiglin, A Demishtein, R Shiloh, M Heiner, SW Kong, Z Elazar, and IS Kohane.

Journal of Biomedical Informatics, 63: 366-378, 2016. 

• Conceptual Modeling of mRNA Decay Provokes Hypotheses 

J Somekh, G Haimovich, A Guterman, D Dori and M Choder

PlOS ONE, 9(9): e107085, 2014. 

• Conceptual Model-Based Systems Biology: Mapping Knowledge and Discovering Gaps in the mRNA Transcription Cycle

J Somekh, M Choder, and D Dori

PLOS ONE, 7(12): e51430, 2012.

• A Methodology for Eliciting and Modeling Exceptions

M Peleg, J Somekh, and D Dori

Journal of Biomedical Informatics, 42(4), pp. 736-747, 2009.