1. Transition Metal and Organo-catalysis: (a) Organo-catalysis, especially N-heterocyclic carbene, iminium catalysis, organoboron, phosphines. (b) Transition metal catalysis and bond activations (c) Cooperative transition metal and organo-catalysis. (d) Efficient systems and ligands designed for modern synthetic chemistry.
2. Metallo-Carbene, Metallo-Nitrene and Metallo-Enzyme Chemistry: (a) Study of metal-carbon frameworks and reactive intermediates. (b) Includes carbene-like and cluster-based species. (c) Important for catalysis and organometallic reactivity (d) Metalloenzymes containing bound metal ions (Fe, Cu, Zn, Mn) in catalysis.
3. Isotope Labelling: (a) Synthesis and Utilisation of ¹³C, ²H, ¹⁵N for tracing reaction pathways. (b) Essential for mechanistic and metabolic studies.
4. Targeted and Asymmetric Synthesis: (a) Design of molecules includes Indole alkaloid multi-cyclic derivatives (b) Method development for controlling enantio- and dia-stereoselectivity in synthesis. (c) Key applications in drug and natural product synthesis.
5. Carbo-heterocyclic Synthesis with Phosphorus (P), Boron (B), Silicon (Si) Molecules: (a) Construction of N-heterocycles and functional heteroatom systems including boron-, phosphorus-, and silicon-containing rings. (b) Widely used in pharmaceuticals and materials science.
Our research program is dedicated to the development of innovative and versatile catalytic strategies for modern organic synthesis. We employ N-heterocyclic carbene (NHCs) catalysis both as ligands in transition-metal complexes and as powerful organocatalysts to enable challenging C–C, C–N, and C–X bond activations. By integrating transition-metal catalysis with NHCs and Lewis acids, our approach allows precise molecular construction, highly efficient and stereoselective transformations, and the discovery of new reaction manifolds. This research offers students the opportunity to engage in cutting-edge catalysis, develop deep mechanistic insight, and contribute creatively to advancing the frontiers of catalysis and synthesis.
Key References:
S. Díez-González, N. Marion, S. P. Nolan, N-Heterocyclic Carbenes in Late Transition Metal Catalysis Chem. Rev. 2009, 109, 3612.
2. Z.-F. Zhang, C.-L. Zhang, S. Ye, N‐Heterocyclic Carbene/Transition Metal Dual Catalysis. Chem. Eur. J. 2024, 30, e202402259.