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Research
Research
[A] Organometallic Chemistry: Light Induced C-H activation Reactions
[B] Photo-Redox Catalysts: Design and Organic Transformations
[C] Photo-Dynamic Therapy of Cancer: Synthesis of Theranostic Agents
[D] Photo-Catalysis: Green Catalysts, Organic Conversions in Sunlight
[E] Bio-imaging BODIPYs: Mitochondria and ER Targeting Molecules
[F] Metal Dipyrrinato Complexes: Phosphorescence and Singlet Oxygen Generation
[A] Organometallic Chemistry: Light Induced C-H activation Reactions
The photocatalytic C−N borylation and C−H arylation mostly depend on the ruthenium and iridium complexes or eosin Y and the use of porphyrin and corroles as catalysts is still in infancy. The photoredox process catalyzed by porphyrins and corroles offers a mild, efficient and metal-free alternative for the formation of C−C, C−S, and C−Se bonds in aryl compounds; it can also be extended to borylation reaction.
Part of the work published in New Journal of Chemistry (2015) and in Dyes and Pigments (2017).
Organometallic Chemistry: Light Induced C-H activation Reactions
[B] Photo-Redox Catalysts: Design and Organic Transformations: Photoredox catalysis provides a green and sustainable alternative for C−H activation of organic molecules that eludes harsh conditions and use of transition metals. Photoredox catalysis has come to the forefront as a powerful tool to execute the formation of challenging carbon–carbon and carbon-heteroatom bonds. The chemistry of C–H activation reactions employing porphyrins and their metal complexes as photoredox catalysts is in early stages. Porphyrin and corrole based photo-redox catalysts are promising for C–H arylation reactions in the mild, green and energy efficient way.
Part of the work published in:
Sensors and Actuators B: Chemical, 244, 673–683, 2017
Luminescence, 1-5, 2017
Journal of Fluorescence, 1-14, 2017
Photo-Redox Catalysts: Design and Organic Transformations
[C] Photo-Dynamic Therapy of Cancer: Synthesis of Theranostic Agents: Photo-Dynamic Therapy (PDT) of cancer involves using light-activated compounds to selectively destroy cancer cells. The synthesis of theranostic agents combines therapeutic and diagnostic functions in a single molecule, enabling targeted treatment and real-time monitoring of cancer progression. Lysosomal enzymes and high accumulation of lipid droplets are associated with breast cancer. The lysosomes and lipid droplets can be monitored by BODIPYs, acting as autophagy activators in cancer cells
Photo-Dynamic Therapy of Cancer: Synthesis of Theranostic Agents
[D] Photo-Catalysis: Green Catalysts, Organic Conversions in Sunlight: Donor− acceptor (D− A) type porphyrins and their metal complexes are synthesized and studied by UV–vis absorption, fluorescence and electrochemical techniques. These porphyrins exhibited efficient energy transfer from the meso-donors to the porphyrin core. Palladium porphyrin are shown to be efficient photo-catalyst for the oxidation of aryl aldehydes in the presence of white LED and sunlight, with high TON and good product yields.
Photo-Catalysis: Green Catalysts, Organic Conversions in Sunlight
[E] Bio-imaging BODIPYs: Mitochondria and ER Targeting Molecules: Bio-imaging BODIPYs (boron-dipyrromethene dyes) are highly fluorescent, photostable molecules widely used for visualizing cellular structures. Lysosomal enzymes and high accumulation of lipid droplets are associated with breast cancer. Their tunable chemical structure allows for precise targeting of organelles like mitochondria and the endoplasmic reticulum (ER). By incorporating specific functional groups, BODIPYs can selectively accumulate in these organelles, enabling real-time imaging and tracking of cellular dynamics. These probes are valuable tools in studying organelle function, disease mechanisms, and drug delivery.
Photo-Catalysis: Green Catalysts, Organic Conversions in Sunlight
Metal Dipyrrinato Complexes: Phosphorescence and Singlet Oxygen Generation:
Ir(III)dipyrrinato complexes have proven to be highly efficient photocatalysts for aerobic oxidation reactions, including photo-oxidative benzylamine coupling, oxidation of sulfides to sulfoxides and the hydroxylation of aryl boronic acids. These reactions proceed with excellent yields within a short reaction time, showcasing the high reactivity and efficiency of these complexes. The exceptional singlet oxygen generation quantum yields, long-lived triplet excited states and strong visible-light absorption make these complexes particularly well-suited for photochemical applications.
Metal Dipyrrinato Complexes: Phosphorescence and Singlet Oxygen Generation
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