Our recent discoveries.....
Our recent discoveries.....
____________________________________________________________
____________________________________________________________
CGGBP1 from higher amniotes restricts cytosine methylation and drives a GC-bias in transcription factor binding sites at repressed promoters. Praveen Kumar, Ishani Morbia, Aditi Lakshmi Satish, Subhamoy Datta, Umashankar Singh
doi: https://doi.org/10.1101/2024.11.14.623544
Morbia I, Kumar P, Satish AL, Mudgal A, Datta S, Singh U. The amniote-
conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of
transcription factor binding sites in proximal promoters to regulate gene
expression. BMC Genom Data. 2024 Nov 18;25(1):98. PMID: 39558239; PMCID: PMC11575156.
Datta S., Patel M., Sathyaseelan C., Ghosh C., Mudgal A., Patel D., Rathinavelan T., Singh U.
G-quadruplex landscape and its regulation revealed by a new antibody capture method.
Oncotarget. 2024; 15: 175-198.
Datta S, Patel M, Kashyap S, Patel D, Singh U. Chimeric chromosome landscapes
of human somatic cell cultures show dependence on stress and regulation of
genomic repeats by CGGBP1. Oncotarget. 2022 Jan 17;13:136-155. doi:
10.18632/oncotarget.28174. PMID: 35070079; PMCID: PMC8765472.
Patel D, Patel M, Datta S, Singh U. CGGBP1-dependent CTCF-binding sites
restrict ectopic transcription. Cell Cycle. 2021 Nov;20(22):2387-2401. doi:
10.1080/15384101.2021.1982508. Epub 2021 Sep 29. PMID: 34585631; PMCID:
PMC8794514.
Patel M, Patel D, Datta S, Singh U. An immunochemistry-based screen for
chemical inhibitors of DNA-protein interactions and its application to human
CGGBP1. BMC Cancer. 2020 Oct 20;20(1):1016. doi: 10.1186/s12885-020-07526-5.
PMID: 33081720; PMCID: PMC7576722.
Patel M, Patel D, Datta S, Singh U. CGGBP1-regulated cytosine methylation at
CTCF-binding motifs resists stochasticity. BMC Genet. 2020 Jul 29;21(1):84. doi:
10.1186/s12863-020-00894-8. PMID: 32727353; PMCID: PMC7392725.
Patel D, Patel M, Datta S, Singh U. CGGBP1 regulates CTCF occupancy at
repeats. Epigenetics Chromatin. 2019 Sep 23;12(1):57. doi:
10.1186/s13072-019-0305-6. PMID: 31547883; PMCID: PMC6757366.
Patel D, Patel M, Westermark B, Singh U. Dynamic bimodal changes in CpG and
non-CpG methylation genome-wide upon CGGBP1 loss-of-function. BMC Res Notes.
2018 Jul 2;11(1):419. doi: 10.1186/s13104-018-3516-1. PMID: 29966527; PMCID:
PMC6027561.
Singh U, Westermark B. CGGBP1--an indispensable protein with ubiquitous
cytoprotective functions. Ups J Med Sci. 2015;120(4):219-32. doi:
10.3109/03009734.2015.1086451. PMID: 26482656; PMCID: PMC4816882.
Agarwal P, Collier P, Fritz MH, Benes V, Wiklund HJ, Westermark B, Singh U.
CGGBP1 mitigates cytosine methylation at repetitive DNA sequences. BMC Genomics.
2015 May 16;16(1):390. doi: 10.1186/s12864-015-1593-2. PMID: 25981527; PMCID:
PMC4432828.
Agarwal P, Enroth S, Teichmann M, Jernberg Wiklund H, Smit A, Westermark B,
Singh U. Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs.
Cell Cycle. 2016 Jun 17;15(12):1558-71. doi: 10.4161/15384101.2014.967094. PMID:
25483050; PMCID: PMC4934077.
Singh U, Maturi V, Jones RE, Paulsson Y, Baird DM, Westermark B. CGGBP1
phosphorylation constitutes a telomere-protection signal. Cell Cycle.
2014;13(1):96-105. doi: 10.4161/cc.26813. Epub 2013 Oct 23. PMID: 24196442;
PMCID: PMC3925742.
Singh U, Westermark B. CGGBP1 is a nuclear and midbody protein regulating
abscission. Exp Cell Res. 2011 Jan 15;317(2):143-50. doi:
10.1016/j.yexcr.2010.08.019. Epub 2010 Sep 9. PMID: 20832400.
Singh U, Roswall P, Uhrbom L, Westermark B. CGGBP1 regulates cell cycle in
cancer cells. BMC Mol Biol. 2011 Jul 7;12:28. doi: 10.1186/1471-2199-12-28.
PMID: 21733196; PMCID: PMC3142506.
Singh U, Bongcam-Rudloff E, Westermark B. A DNA sequence directed mutual
transcription regulation of HSF1 and NFIX involves novel heat sensitive protein
interactions. PLoS One. 2009;4(4):e5050. doi: 10.1371/journal.pone.0005050. Epub
2009 Apr 1. PMID: 19337383; PMCID: PMC2660424.