Research Areas

Hydrogels and Hydrogel Nanoparticles for Drug Delivery

In recent years I have used the expertise I have developed in polymer reaction engineering, especially the NF technique, in modeling of polymer production for biomedical applications. Of prime interest to my work is the formation of hydrogels, and hydrogel nanoparticles used as scaffolds, and biomaterials for angiogenesis, wound healing and controlled delivery. Through the development of experimental protocols and mathematical models, we were able to develop and optimize hydrogels and nanoparticles for various applications as demonstrated by these selected publications:

  • Borges, Fernando TP, Georgia Papavasiliou, and Fouad Teymour. "Characterizing the Molecular Architecture of Hydrogels and Crosslinked Polymer Networks beyond Flory–Rehner—I. Theory." Biomacromolecules 21, no. 12 (2020): 5104-5118.

  • Pimentel MB, Borges FTP, Teymour F, Zaborina OY, Alverdy JC, Kuili F, Hong SH, Staneviciute A, He Y, Papavasiliou G. In vitro screening of phosphate-based therapeutic attenuation of pathogen-induced matrix degradation using hydrogel nanocomposite platforms. Journal of Materials Chemistry B. 8(2): 2454-2465, 2020.

  • Nichols, Dylan, Marja Pimentel, Fernando TP Borges, Sanjiv Kumar Hyojuh, Fouad Teymour, Seok Hoon Hong, Olga Y. Zaborina, John Chris Alverdy, and Georgia Papavasiliou. "Sustained Release of Polyphosphate from Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation In Vitro." Frontiers in Bioengineering and Biotechnology 7 (2019): 153.

  • Yin, Yushu, Georgia Papavasiliou, Olga Y. Zaborina, John C. Alverdy, and Fouad Teymour. “De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly (Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas Aeruginosa as a Model Intestinal Pathogen.” Annals of Biomedical Engineering 45(4) pp. 1058–1068, 2017.