IISER TVM is about 45 km from the Thiruvananthapuram airport and railway station.

The charge for a taxi trip is around Rs. 1800/- INR from the Airport/Central railway station to the IISER TVM permanent campus. 

The optimal road is via intermediate towns, Nedumangad and Vithura.

The campus is located about 7 kilometers from Vithura.

The journey from the city to the campus takes about 1 hour 30 minutes.

KSRTC (Kerala State Road Transport Corporation) bus services are available from KSRTC Central bus station known as Thampanoor.