Welcome
Welcome
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The Indian Institute of Science Education and Research Berhampur, established in 2016 by the Ministry of Human Resource Development, Government of India is a Center of Excellence dedicated to teaching and research in basic sciences. As a unique initiative in science education in India, IISER Berhampur aims to be a University of the highest caliber devoted to both high quality teaching and state-of-the-art research in a totally integrated manner, thus nurturing both curiosity and creativity.
WHAT IS iGEM?
WHAT IS iGEM?
The International Genetically Engineered Machine (iGEM) Foundation is an independent, non-profit organization dedicated to the advancement of synthetic biology, education and competition, and the development of an open community and collaboration. This is done by fostering an open, cooperative community, and friendly competition.
iGEM’s biggest program is the iGEM Competition. The iGEM Competition gives students the opportunity to push the boundaries of synthetic biology by tackling everyday issues facing the world. Made up of primarily university students, multidisciplinary teams work together to design, build, test, and measure a system of their own design using interchangeable biological parts and standard molecular biology techniques. Every year nearly 6,000 people dedicate their summer to iGEM and then come together in the fall to present their work and compete at the annual Jamboree. For more info visit here : iGEM
The IISER Berhampur iGEM team is a group of undergraduate students hailing from diverse disciplines. This year marks our maiden attempt in participating in this competition. We aim to formulate an intervention strategy for Dengue Virus by combining mathematical modelling, in silico analysis and chemical biology. The essence is to design an efficacious reporter system to implement our strategy as possible therapeutics that may spark further research to combat this dreaded disease.
ORIGIN OF 0ur project PROPOSAL
ORIGIN OF 0ur project PROPOSAL
The incidence of dengue, the disease our project is all about, has increased 30 times over the last 50 years. Up to 390 million infections have been estimated to occur annually around the world, putting over half of the world population at risk. Normally, dengue is not that dangerous, symptoms are mild rashes and the fever dies down after a few days. But in some cases it can lead to the deadly dengue hemorrhagic fever or dengue shock syndrome, where the body looses water very rapidly and blood does not coagulate. The present treatment includes close monitoring of fluids in the body. Till now there is no specific medicine or an effective vaccine to treat or prevent dengue infection.
So, some of the science folk here at IISER Berhampur got together and devised a strategy that will exploit the myriad protein-protein interactions that this little virus so skillfully uses. We hope to design a peptide inhibitor that targets and breaks the interaction of two proteins in the DENV pathogenesis pathways as a possible intervention game plan. Explore our project to learn about some of the exciting ways that synthetic biology can be used practically to combat this disease.
About our logo
About our logo
The centre of our project NSIPR is DENV or the virus behind dengue fever , so we chose to make it the protagonist of our logo as well. But what is the arbovirus without it's vector? The green snitch you see, just the wings of the Aedes aegypti carrying dengue virus. And did we add the stereotype for genetic engineering as well? Lets just say justice was done for design's sake.
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