V01P01.IJEIR.2011
75506.pdfUltrastructural and morphometric study of the glomerular filtration slit during neonatal period
Anam Rashid Al-Salihi
Aida Hameed Al-Obaide
High Institute for the diagnosis of infertility and assisted reproduction techniques at Al Nahrain University
College of Medicine, Wasit University
Abstract
Background
The functional and morphological development of the glomerius is an essential part of nephrogenesis that takes place during Intra uterine life and early post-naiat days.
Objectives
To study the morphometric parameters of the maturation of the glomerular filtration slit of the kidney during neonatal period and its implication on the function of the kidney.
Method
Rat litters are used as a mammalian model of the development during the first 8 days of post -natal life. Image analysis using Bell software system was used for morphmetric measurement of filtration silt as examined by electron microscope-
Results
The width of the filtration slit of new born kidney was 11.24±1.6 nm which increased by increment to be 14.83+1,6 nm on 4th .post- natai day. Eventually reached 25.34±4.3 nm on day 8 post natally.
Conclusions
In New Born litters, the glomerular filtration slit is narrower than that of mature kidney. Glomerular development continues to take place during first post natal week to reach the adult mature parameters at the end of neonatal period. This explains the low GFR found in new born mammals.