Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo

(doi: 10.1021/acs.chemneuro.9b00242)

Vini-Fiorella Buttino

Cal Poly Humboldt Biochemistry Major

October 28th, 2022 2:00 – 2:50PM (SciA 564)

ABSTRACT

Neurological diseases ranging from Alzheimer’s to Vascular dementia have been estimated to affect 5 million adults over the ages of 65, as of 2014. Those suffering from dementia will exhibit impaired reasoning skills, memory loss, and decreased communication skills. Common factors these neurodegenerative diseases share is the degeneration of synaptic functions caused by vasospasm, angiostenosis, and angiemphraxis. MN-12 is a memantine nitrate designed to treat neurodegenerative disorders by providing improved cerebral blood flow, which has been shown to exhibit anti-apoptotic properties. By potentially binding to guanylyl cyclase and acting as a potent vasodilator, NO donors have been shown to promote pro-survival effects against neurotoxicity and, in some cases, reversed excitotoxicity in vitro and in vivo.

Key words: dementia, Alzheimer’s disease, vascular dementia, Neuroprotection, vasodilation