Publications
(updated 1/26/2026)
Embedded Files
Book Chapters
Book Chapters
Carr, P.W., Davis, J.M., Rutan, S.C., Stoll, D.R., Principles of Multi-Dimensional Liquid Chromatography. In Advances in Chromatography, eds. N. Grinberg, E. Grushka, CRC Press, 2012, pp. 140-222.
Stoll, D.R., Groskreutz, S.R. Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation. In Hydrophilic Interaction Chromatography: a Guide for Practitioners, Chemical Analysis, Wiley, 2013, pp. 265–305.
Stoll, D.R. Introduction to Two-Dimensional Liquid Chromatography – Theory and Practice. In Handbook of Advanced Chromatography/Mass Spectrometry Techniques, eds. M. Holčapek, Wm. C. Byrdwell, Elsevier, 2017, pp. 227-286.
Carr, P.W., Stoll, D.R., A study of peak capacity optimization in one-dimensional gradient elution reversed-phase chromatography: a memorial to Eli Grushka. In Advances in Chromatography, ed. N. Grinberg, CRC Press, 2018, pp. 1-21.
Stoll, D.R., Zhang, K., Staples, G.O., Beck, A., Recent Advances in Two-Dimensional Liquid Chromatography for the Characterization of Monoclonal Antibodies and Other Therapeutic Proteins. In Advances in Chromatography, eds. N. Grinberg, P.Carr, CRC Press, 2018, pp.28-63.
Stoll, D.R. 2D-HPLC: Method Development for Successful Separations. In Optimization in HPLC: concepts and strategies; Kromidas, S., Ed.; Wiley-VCH: Weinheim, 2021; pp 3–18.
Books
Books
Multi-Dimensional Liquid Chromatography: Principles, Practice, and Applications; Stoll, D. R., Carr, P. W., Eds.; CRC PRESS: Boca Raton, FL, 2023.
Peer-Reviewed Publications
Peer-Reviewed Publications
* Indicates Gustavus undergraduate students
Dunlap, C. J.; McNeff, C. V.; Stoll, D. R.; Carr, P. W. "Zirconia stationary phases for extreme separations." Analytical Chemistry 2001, 73, 598A-607A.
Schellinger, A. P.; Stoll, D. R.; Carr, P. W. "High speed gradient elution reversed-phase liquid chromatography." Journal of Chromatography A 2005, 1064, 143-156.
Stoll, D. R.; Carr, P. W. "Fast, Comprehensive Two-dimensional HPLC separation of tryptic peptides based on High-Temperature HPLC." Journal of the American Chemical Society 2005, 127, 5034-5035.
Wang, X.; Stoll, D. R.; Schellinger, A. P.; Carr, P. W. "Peak capacity optimization of peptide separations in reversed-phase gradient elution chromatography: fixed column format." Analytical Chemistry 2006, 78, 3406-3416.
Wang, X.; Stoll, D. R.; Carr, P. W.; Schoenmakers, P. J. "A graphical method for understanding the kinetics of peak capacity production in gradient elution liquid chromatography." Journal of Chromatography A 2006, 1125, 177-181.
Stoll, D. R.; Cohen, J. D.; Carr, P. W. "Fast, comprehensive two-dimensional HPLC through the use of High Temperature Ultra-Fast Gradient Elution RPLC." Journal of Chromatography A 2006, 1122, 123-137.
Porter, S. E. G.; Stoll, D. R.; Rutan, S. C.; Carr, P. W.; Cohen, J. D. "Analysis of four-way two-dimensional liquid chromatography – diode array data: Application to metabolomics." Analytical Chemistry 2006, 78, 5559-5569.
Schellinger, A. P.; Stoll, D. R.; Carr, P. W. "High speed gradient elution RPLC of bases in buffered eluents Part II: Full equilibrium." Journal of Chromatography, A 2008, 1192, 54-61.
Schellinger, A. P.; Stoll, D. R.; Carr, P. W. "High speed gradient elution RPLC of bases in buffered eluents Part I: Retention repeatability and column reequilibration." Journal of Chromatography, A 2008, 1192, 43-51.
Stoll, D.R., C. Paek, and P.W. Carr. “Fast gradient elution reversed-phase HPLC with diode-array detection as a high throughput screening method for drugs of abuse. I: Chromatographic conditions. Journal of Chromatography A, 2006, 1137, 153-162.
Porter, S. E. G.; Stoll, D. R.; Carr, P. W.; Rutan, S. C. "Fast gradient elution reversed-phase HPLC with diode-array detection as a high throughput screening method for drugs of abuse. II: Data analysis." Journal of Chromatography A 2006, 1137, 163-172.
Stoll, D. R.; Li, X.; Wang, X.; Porter, S. E. G.; Rutan, S. C.; Carr, P. W. "High temperature, fast two-dimensional liquid chromatography." Journal of Chromatography A, 2007, 1168, 3-43, doi:10.1016/j.chroma.2007.08.054.
McNeff, C., V.; Yan, B.; Stoll, D., R.; Henry, R. "Practice and theory of high temperature liquid chromatography." Journal of Separation Science, 2007, 30, 1672-1685.
Davis, J. M.; Stoll, D., R.; Carr, P. W. "Effect of first dimension undersampling on effective peak capacity in comprehensive two-dimensional separations." Analytical Chemistry 2008, 80, 461-473, doi: 10.1021/ac071504j.
Stoll, D., R.; Wang, X.; Carr, P. W. "A comparison of the practical resolving power of one- and two-dimensional High Performance Liquid Chromatography analysis of metabolomic samples." Analytical Chemistry 2008, 80, 268-278, 10.1021/ac701676b.
Davis, J. M.; Stoll, D. R.; Carr, P.W. “Dependence of effective peak capacity in comprehensive two-dimensional separations on the distribution of peak capacity between the two dimensions.” Analytical Chemistry 2008, 80, 8122-8134, doi: 10.1021/ac800933z.
Reichenbach, S. E.; Carr, P. W.; Stoll, D. R.; Tao, Q. “Smart templates for peak pattern matching with comprehensive two-dimensional liquid chromatography.” Journal of Chromatography, A, 2008, 1216, 3458-3466, doi:10.1016/j.chroma.2008.09.058.
Li, X.; Stoll, D. R.; Carr, P. W. “Equation for peak capacity estimation in two-dimensional liquid chromatography.” Analytical Chemistry, 2008, 81, 845-850, doi:10.1021/ac801772u.
Carr, P.W.; Wang, X.; Stoll, D.R. “Effect of Pressure, Particle Size, and Time on Optimizing Performance in Liquid Chromatography.” Analytical Chemistry, 2009, 81, 5342-5353, doi: 10.1021/ac9001244.
Stoll, D.R. “Guidelines for Bioanalytical 2D-Chromatography Method Development and Implementation.” Bioanalysis, 2009, 2, 105-122, doi: 10.4155/bio.09.131.
Stoll, D. R. "Recent progress in online, comprehensive two-dimensional high-performance liquid chromatography for non-proteomic applications." Analytical and Bioanalytical Chemistry, 2010, 397, 979-986, doi: 10.1007/s00216-010-3659-y.
Reichenbach, S. E.; Tian, X.; Tao, Q.; Stoll, D. R.; Carr, P. W. "Comprehensive feature analysis for sample classification with comprehensive two-dimensional LC." Journal of Separation Science, 2010, 33, 1-11, doi: 10.1016/j.aca.2008.07.036.
Potts, L. W.; Stoll, D. R.; Li, X.; Carr, P. W. “The impact of sampling time on peak capacity and analysis speed in on-line comprehensive two-dimensional liquid chromatography.” Journal of Chromatography, A, 2010, 1217, 5700-5709, doi: 10.1016/j.chroma.2010.07.009.
Simpkins, S.*; Bedard, J. *; Groskreutz, S. *; Swenson, M. *; Liskutin, T. *; Stoll, D.R., “Targeted three-dimensional liquid chromatography - A Versatile tool for quantitative trace analysis in complex matrices.” Journal of Chromatography, A, 2010, 1217, 7648-7660, doi: 10.1016/j.chroma.2010.09.023.
Carr, P.W.; Wang, X.; Stoll, D.R. “Perspectives on Recent Advances in the Speed of High Performance Liquid Chromatography.” Analytical Chemistry 2010, 83, 1890-1900, doi: 10.1021/ac102570t.
Wang, X.; Carr, P.W.; Stoll, D.R. "A Simple Approach to Performance Optimization in HPLC and Its Application in Ultrafast Separation Development." LC-GC 2010, 28, 11, 932-942.
Groskreutz, S.*; Swenson, M.*; Secor, L.*; Stoll, D. R. “Selective Comprehensive Multi-dimensional Separation for Resolution Enhancement in High Performance Liquid Chromatography, Part I–Principles and Instrumentation.” Journal of Chromatography, A. 2012, 1228, 31-40, doi: 10.1016/j.chroma.2011.06.035.
Groskreutz, S.*; Swenson, M.*; Secor, L.*; Stoll, D. R. “Selective Comprehensive Multi-dimensional Separation for Resolution Enhancement in High Performance Liquid Chromatography, Part II–Applications.” Journal of Chromatography, A. 2012, 1228, 41-50, doi: 10.1016/j.chroma.2011.06.038.
Johnson, A.; Johnson, C.*; Stoll, D.; Vitha, M. “Identifying orthogonal and similar reversed phase liquid chromatography stationary phases using the system selectivity cube and the hydrophobic subtraction model.” Journal of Chromatography A. 2012, 1249, 62-82, doi: 10.1016/j.chroma.2012.05.049.
Bailey, H..; Rutan, S.; Stoll, D. “Chemometric analysis of targeted 3DLC-DAD data for accurate and precise quantification of phenytoin in wastewater samples.” Journal of Separation Science 2012, 35, 1837–1843, doi: 10.1002/jssc.201200053.
Boswell, P., Stoll, D., Carr, P., Nagel, M., Vitha, M., Mabbott, G. “An Advanced, Interactive, High-Performance Liquid Chromatography Simulator and Instructor Resources.” Journal of Chemical Education 2013, 90, 198–202, doi: 10.1021/ed300117b.
Larson, E.*, Groskreutz, S.*, Harmes, D., Gibbs-Hall, I.*, Trudo, S., Allen, R., Rutan, S., Stoll, D. “Development of selective comprehensive two-dimensional liquid chromatography with parallel first-dimension sampling and second-dimension separation - application to the quantitative analysis of furanocoumarins in apiaceious vegetables.” Analytical and Bioanalytical Chemistry 2013, 405, 4639-4653, doi: 10.1007/s00216-013-6758-8.
Tran, T.*, Gibbs-Hall, I.*, Young, P.*, Thompson, J., Stoll, D. “Characterization of fullerene-modified silicas as a complement to existing graphite-like phases for use in two-dimensional liquid chromatography.” Analytical Chemistry 2013, 85, 11817-11825, doi: 10.1021/ac4023428.
Davis, J. M., Stoll, D. R. “Likelihood of total resolution in liquid chromatography: Evaluation of one-dimensional, comprehensive two-dimensional, and selective comprehensive two-dimensional liquid chromatography.” Journal of Chromatography A 2014, 1360, 128–142, doi:10.1016/j.chroma.2014.07.066.
Stoll, D., Talus, E.*, Harmes, D., Zhang, K. “Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants.” Analytical and Bioanalytical Chemistry 2014, 407, 265-277, doi:10.1007/s00216-014-8036-9.
Cook, D., Rutan, S., Stoll, D., Carr, P. “2D assisted liquid chromatography (2DALC) – A chemometric approach to improve accuracy and precision of quantitation in liquid chromatography using 2D separation, dual detectors, and multivariate curve resolution.” Analytica Chimica Acta 2015, 859, 87–95, doi:10.1016/j.aca.2014.12.009.
Talus, E.*, Witt, K., Stoll, D. “Effect of pressure pulses at the interface valve on the stability of second dimension columns in online comprehensive two-dimensional liquid chromatography.” Journal of Chromatography A 2015, 1378, 50–57, doi: 10.1016/j.chroma.2014.12.019.
Stoll, D., O’Neill, K.*, Harmes, D. “Effect of pH mismatch between the two dimensions of reversed-phase x reversed-phase two-dimensional separations on second dimension separation quality for ionogenic compounds – I. Carboxylic acids.” Journal of Chromatography, A 2015, 1383, 25-34, doi:10.1016/j.chroma.2014.12.054.
Abate-Pella, D., Stoll, D., Carr, P., Boswell, P. “An open-source simulator for exploring HPLC theory.”, LCGC North America 2015, 33, 200–207.
Stoll, D., Harmes, D., Danforth, J.*, Wagner-Rousset, E., Guillarme, D., Fekete, S., Beck, A. “Direct identification of rituximab main isoforms and subunit analysis by online selective comprehensive two-dimensional liquid chromatography – mass spectrometry.” Analytical Chemistry 2015, 87, 8307-8315. doi:10.1021/acs.analchem.5b01578.
Abate-Pella, D., Freund, D., Ma, Y., Simón-Manso, Y., Hollender, J., Broeckling, C., Huhman, D., Krokhin, O., Stoll, D., Hegeman, A., Kind, T., Fiehn, O., Schymanski, E., Prenni, J., Sumner, L., Boswell, P. “Retention projection enables accurate calculation of liquid chromatographic retention times across labs and methods.” Journal of Chromatography, A. 2015, 1412, 43–51. doi:10.1016/j.chroma.2015.07.108.
Stoll, D. “Recent advances in 2D-LC for bioanalysis.” Bioanalysis 2015, 7 (24), 3125-3142, doi: 10.4155/bio.15.223.
Stoll, D., Danforth, J.*, Zhang, K., Beck, A. “Characterization of therapeutic antibodies and related products by two-dimensional liquid chromatography coupled with UV absorbance and mass spectrometric detection.” Journal of Chromatography, B. 2016, 1032, 51-60. doi:10.1016/j.jchromb.2016.05.029.
Jeong, L., Sajulga, R.*, Forte, S., Stoll, D., Rutan, S. “Simulation of elution profiles in liquid chromatography—I: Gradient elution conditions, and with mismatched injection and mobile phase solvents.” Journal of Chromatography, A 2016, 1457, 41-49. doi:10.1016/j.chroma.2016.06.016.
Sorensen, M.*, Harmes, D., Stoll, D., Staples, G., Fekete, S., Guillarme, D., Beck, A. “Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry.” mAbs 2016, 8 (7), 1224-1234. doi:10.1080/19420862.2016.1203497.
Stoll, D., Carr, P.W. “Two-dimensional liquid chromatography: A state of the art tutorial.” Analytical Chemistry 2017, 89, 519–531. doi:10.1021/acs.analchem.6b03506.
Halvorson, J.*, Lenhoff, A., Dittmann, M., Stoll, D. “Implications of turbulent flow in connecting capillaries used in high performance liquid chromatography.” Journal of Chromatography, A 2016, In Press. doi:10.1016/j.chroma.2016.12.084.
Cook, D., Burnham, M.*, Harmes, D.C., Stoll, D., Rutan, S. “Comparison of multivariate curve resolution strategies in quantitative LCxLC: Application to the quantification of furanocoumarins in apiaceous vegetables.” Analytica Chimica Acta 2017, 961, 49–58. doi:10.1016/j.aca.2017.01.047.
Stoll, D., Shoykhet, K., Petersson, P., Buckenmaier, S. “Active solvent modulation – A valve-based approach to improve separation compatibility in two-dimensional liquid chromatography.” Analytical Chemistry 2016, 87, 9260-9267. doi: 10.1021/acs.analchem.7b02046.
Stoll, D., Sajulga, R.*, Voigt, B.*, Larson, E.*, Jeong, L., Rutan, S. “Simulation of elution profiles in liquid chromatography—II: Investigation of injection volume overload under gradient elution conditions applied to second dimension separations in two-dimensional liquid chromatography.” Journal of Chromatography, A 2017, 1523, 162-172. doi: 10.1016/j.chroma.2017.07.041.
Kim, J.D., Strapazzon, N., Gallaher, C.M., Stoll, D.R., Thomas, W., Gallaher, D.D., Trudo, S.P. “Comparison of short- and long-term exposure effects of cruciferous and apiaceous vegetables on carcinogen metabolizing enzymes in Wistar rats.” Food and Chemical Toxicology 2017, 108, 194–202. doi: 10.1016/j.fct.2017.07.057.
Stoll, D., Maloney, T. “Recent advances in two-dimensional liquid chromatography for pharmaceutical and biopharmaceutical analysis”, LCGC North America 2017, 35, 680-687.
Wang, X., Buckenmaier, S., Stoll, D. “The growing role of two-dimensional LC in the biopharmaceutical industry”, Journal of Applied Bioanalysis 2017, 3, 120-126. doi: 10.17145/jab.17.015.
Davis, J., Stoll, D. “Likelihood of total resolution in selective comprehensive two-dimensional liquid chromatography with parallel processing: Simulation and theory”, Journal of Chromatography, A 2017, 1537, 15-37. doi: 10.1016/j.chroma.2017.12.035.
Stoll, D., Harmes, D.C., Staples, G., Potter, O., Dammann, C.*, Guillarme, D., Beck, A. “Development of comprehensive online two-dimensional liquid chromatography-mass spectrometry using hydrophilic interaction and reversed-phase separations for rapid and deep profiling of therapeutic antibodies, Analytical Chemistry, 2018, 90, 5923–5929. doi:10.1021/acs.analchem.8b00776.
Lindsey, R., Eggimann, B., Stoll, D., Carr, P., Schure, M., Siepmann, I., Column selection for comprehensive two-dimensional liquid chromatography using the hydrophobic subtraction model, Journal of Chromatography A. 2018, In Press. doi:10.1016/j.chroma.2018.09.018.
D’Atri, V.; Fekete, S.; Stoll, D.; Lauber, M.; Beck, A.; Guillarme, D. Characterization of an Antibody-Drug Conjugate by Hydrophilic Interaction Chromatography Coupled to Mass Spectrometry. Journal of Chromatography B 2018, 1080, 37–41. doi: 10.1016/j.jchromb.2018.02.026.
Pirok, B. W. J.; Stoll, D., R.; Schoenmakers, P. J. Recent developments in two-dimensional liquid chromatography – Fundamental improvements for practical applications. Analytical Chemistry 2018, 91, 240-263. doi: 10.1021/acs.analchem.8b04841.
M. Eckberg N., L. Arroyo-Mora E., D. Stoll R., A. DeCaprio P., Separation and Identification of Isomeric and Isobaric Synthetic Cannabinoids Using Two-Dimensional Liquid Chromatography and High Resolution Mass Spectrometry, Journal of Analytical Toxicology 2018, In Press. doi:10.1093/jat/bky081.
V. D’Atri, L. Nováková, S. Fekete, D. Stoll, M. Lauber, A. Beck, D. Guillarme, Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass Spectrometry, Analytical Chemistry, 2019, 91, 873–880. doi:10.1021/acs.analchem.8b03584.
G. Leme, B. Madigan, J.* Eikens, D.C.* Harmes, D. Richardson, P. Carr, D. Stoll, In situ Measurement of pH in Liquid Chromatography Systems Using a Colorimetric Approach, Analytical Methods, 2019, 11, 381-386. doi:10.1039/C8AY02496K.
D.W. Cook, K.G. Oram, S.C.* Rutan, D.R. Stoll, Rational Design of Mixtures for Chromatographic Peak Tracking Applications via Multivariate Selectivity, Analytica Chimica Acta: X. 2019, In Press. doi:10.1016/j.acax.2019.100010.
C. Seidl, D. Bell, D.R. Stoll, A Study of the Re-Equilibration of Hydrophilic Interaction Columns with a Focus on Viability for Use in Two-Dimensional Liquid Chromatography, Journal of Chromatography, A. 2019, In Press. doi: 10.1016/j.chroma.2019.460484.
Stoll, D., Lhotka, H.*, Harmes, D. C., Madigan, B.*, Hsiao, J., Staples, G. O. High Resolution Two-Dimensional Liquid Chromatography Coupled with Mass Spectrometry for Robust and Sensitive Characterization of Therapeutic Antibodies at the Peptide Level. Journal of Chromatography B 2019, In Press. doi: 10.1016/j.jchromb.2019.121832.
Dunn, Z., Desai, J., Leme, G., Stoll, D., Richardson, D. Rapid two-dimensional Protein-A size exclusion chromatography for determination of titer and aggregation for monoclonal antibodies in harvested cell culture fluid samples. mAbs, 2020, 12 (1), xx-yy. doi: 10.1080/19420862.2019.1702263.
Desmet, G.; Song, H.; Makey, D.*; Stoll, D. R.; Cabooter, D. Experimental investigation of the retention factor dependency of eddy dispersion in packed bed columns and relation to Knox’s empirical model parameters. Journal of Chromatography A 2020, 1626, In Press. doi:10.1016/j.chroma.2020.461339.
Moussa, A., Lauer, T.*, Stoll, D., Desmet, G., Broeckhoven, K. Numerical and experimental investigation of analyte breakthrough from sampling loops used for multi-dimensional liquid chromatography. Journal of Chromatography A 2020, 1626, In Press. doi:10.1016/j.chroma.2020.461283.
Weatherbee, S. L.; Brau, T.*; Stoll, D. R.; Rutan, S. C.; Collinson, M. M. Simulation of elution profiles in liquid chromatography – IV: Experimental characterization and modeling of solute injection profiles from a modulation valve used in two-dimensional liquid chromatography. Journal of Chromatography A 2020, 1626, 461373. doi:10.1016/j.chroma.2020.461373.
Karongo, R.; Ikegami, T.; Stoll, D. R.; Lämmerhofer, M. A Selective Comprehensive Reversed-Phase×reversed-Phase 2D-Liquid Chromatography Approach with Multiple Complementary Detectors as Advanced Generic Method for the Quality Control of Synthetic and Therapeutic Peptides. Journal of Chromatography A 2020, 1627, In Press. doi:10.1016/j.chroma.2020.461430.
Cabooter, D.; Song, H.; Makey, D.*; Sadriaj, D.; Dittmann, M.; Stoll, D.; Desmet, G. Measurement and modelling of the intra-particle diffusion and b-term in reversed-phase liquid chromatography, Journal of Chromatography A. 2021 1637, In Press. doi.org/10.1016/j.chroma.2020.461852.
Shoykhet, K.; Stoll, D.; Buckenmaier, S. Constant pressure mode of operation in the second dimension of two-dimensional liquid chromatography: A proof of concept, Journal of Chromatography A. 2021 1639, In Press. doi.org/10.1016/j.chroma.2021.461880.
Stoll, D.; Dahlseid, T.; Rutan, S.; Taylor, T.; Serret J., Improvements in the predictive accuracy of the hydrophobic subtraction model of reversed-phase selectivity, Journal of Chromatography A. 2020, In Press. doi.org/10.1016/j.chroma.2020.461682.
den Uijl, M.; Schoenmakers, P.; Schulte, G.*; Stoll, D.; van Bommel, M.; Pirok, B. Measuring and using scanning-gradient data for use in method optimization for liquid chromatography, Journal of Chromatography A. 2021, 1636, In Press. doi.org/10.1016/j.chroma.2020.461780.
Molenaar, S.;. Dahlseid, T.; Leme, G.; Stoll, D.; Schoenmakers, P.; Pirok, B. Peak-tracking algorithm for use in comprehensive two-dimensional liquid chromatography – Application to monoclonal-antibody peptides, Journal of Chromatography A. 2021, 1639, In Press. doi.org/10.1016/j.chroma.2021.461922.
Gunnarson, C.*;. Lauer, T.*; Willenbring, H.*; Larson, E.*; Dittmann, M.; Broeckhoven, K.; Stoll, D. Implications of dispersion in connecting capillaries for separation systems involving post-column flow splitting, Journal of Chromatography A. 2021, In Press. doi:10.1016/j.chroma.2021.461893.
J. De Vos, D. Stoll, S. Buckenmaier, S. Eeltink, J.P. Grinias, Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows, Analytical Science Advances. 2 2021 171–192. https://doi.org/10.1002/ansa.202100007.
M. Pérez-Cova, C. Bedia, D.R. Stoll, R. Tauler, J. Jaumot, MSroi: a pre-processing tool for mass spectrometry-based studies, Chemometrics and Intelligent Laboratory Systems. 2021 104333. https://doi.org/10.1016/j.chemolab.2021.104333.
D.M. Makey, V. Shchurik, H. Wang, H.R. Lhotka, D.R. Stoll, A. Vazhentsev, I. Mangion, E.L. Regalado, I.A.H. Ahmad, Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling, Analytical Chemistry. 93 2021 964–972. https://doi.org/10.1021/acs.analchem.0c03680.
S.C. Rutan, L.N. Jeong, P.W. Carr, D.R. Stoll, S.G. Weber, Closed form approximations to predict retention times and peak widths in gradient elution under conditions of sample volume overload and sample solvent mismatch, Journal of Chromatography, A. 1653 2021 462376. https://doi.org/10.1016/j.chroma.2021.462376.
I.A. Haidar Ahmad, D.M. Makey, H. Wang, V. Shchurik, A.N. Singh, D.R. Stoll, I. Mangion, E.L. Regalado, In Silico Multifactorial Modeling for Streamlined Development and Optimization of Two-Dimensional Liquid Chromatography, Analytical Chemistry. 2021 acs.analchem.1c01970. https://doi.org/10.1021/acs.analchem.1c01970.
A. Moussa, T. Lauer, D. Stoll, G. Desmet, K. Broeckhoven, Modelling of analyte profiles and band broadening generated by interface loops used in multi-dimensional liquid chromatography, Journal of Chromatography, A. 2021 462578. https://doi.org/10.1016/j.chroma.2021.462578.
E.L. Regalado, I.A. Haidar Ahmad, G.L. Losacco, V. Shchurik, X. Wang, R. Cohen, A.N. Herron, S. Aiken, D. Fiorito, H. Wang, M. Reibarkh, T. Nowak, A.A. Makarov, D.R. Stoll, D. Guillarme, I. Mangion, V.K. Aggarwal, J.-Q. Yu, Trapping‐Enrichment Multidimensional Liquid Chromatography with On‐Line Deuterated Solvent Exchange for Streamlined Structure Elucidation at the Microgram Scale, Angewante Chemie, International Edition. 2022 anie.202117655. https://doi.org/10.1002/anie.202117655.
M. Pérez-Cova, S. Platikanov, D.R. Stoll, R. Tauler, J. Jaumot, Comparison of Multivariate ANOVA-Based Approaches for the Determination of Relevant Variables in Experimentally Designed Metabolomic Studies, Molecules, 27, 2022 3304. https://doi.org/10.3390/molecules27103304.
C. Seidl, J.M. de Lima, G.M. Leme, A.F. Pires, D.R. Stoll, C.L. Cardoso, A Comprehensive 2D-LC/MS Online Platform for Screening of Acetylcholinesterase Inhibitors, Frontiers in Molecular Biosciences. 9 2022 868597. https://doi.org/10.3389/fmolb.2022.868597.
T. Brau, B. Pirok, S. Rutan, D. Stoll, Accuracy of retention model parameters obtained from retention data in liquid chromatography, Journal of Separation Science. 2022 jssc.202100911. https://doi.org/10.1002/jssc.202100911.
D.R. Stoll, G. Kainz, T.A. Dahlseid, T. Kempen, T. Brau, B. Pirok, An Approach to High Throughput Measurement of Accurate Retention Data in Liquid Chromatography, Journal of Chromatography, A, 2022 463350. https://doi.org/10.1016/j.chroma.2022.463350.
J.K. Field, J. Bruce, S. Buckenmaier, M.Y. Cheung, M.R. Euerby, K.F. Haselmann, J.F. Lau, D. Stoll, M. Sylvester, H. Thogersen, P. Petersson, Method Development for Reversed-Phase Separations of Peptides: A Rational Screening Strategy for Column and Mobile Phase Combinations with Complementary Selectivity, LCGC Europe, 2022 440–449. https://doi.org/10.56530/lcgc.eu.qp3971p2.
S.W. Foster, D. Parker, S. Kurre, J. Boughton, D.R. Stoll, J.P. Grinias, A review of two-dimensional liquid chromatography approaches using parallel column arrays in the second dimension, Analytica Chimica Acta, 1228, 2022 340300. https://doi.org/10.1016/j.aca.2022.340300.
T.S. Bos, J. Boelrijk, S.R.A. Molenaar, B. van ’t Veer, L.E. Niezen, D. van Herwerden, S. Samanipour, D.R. Stoll, P. Forré, B. Ensing, G.W. Somsen, B.W.J. Pirok, Chemometric Strategies for Fully Automated Interpretive Method Development in Liquid Chromatography, Analytical Chemistry, 94, 2022 16060–16068. https://doi.org/10.1021/acs.analchem.2c03160.
Z. Liu, Y. Zhou, Q. Wang, J.P. Foley, D.R. Stoll, J.G. Shackman, Development of tandem-column liquid chromatographic methods for pharmaceutical compounds using simulations based on hydrophobic subtraction model parameters, Journal of Chromatography A, 1695, 2023 463925. https://doi.org/10.1016/j.chroma.2023.463925.
D.R. Stoll, M. Sylvester, M.R. Euerby, S.M.C. Buckenmaier, P. Petersson, A Strategy for assessing peak purity of pharmaceutical peptides in reversed-phase chromatography methods using two-dimensional liquid chromatography coupled to mass spectrometry. Part II: Development of second-dimension gradient conditions, Journal of Chromatography A. 1693, 2023 463873. https://doi.org/10.1016/j.chroma.2023.463873.
P. Petersson, S. Buckenmaier, M.R. Euerby, D.R. Stoll, A strategy for assessing peak purity of pharmaceutical peptides in reversed-phase chromatography methods using two-dimensional liquid chromatography coupled to mass spectrometry. Part I: Selection of columns and mobile phases, Journal of Chromatography A, 1693, 2023 463874. https://doi.org/10.1016/j.chroma.2023.463874.
T. Kempen, T. Dahlseid, T. Lauer, A.C. Florea, I. Aase, N. Cole-Dai, S. Kaur, C. Southworth, K. Grube, J. Bhandari, M. Sylvester, R. Schimek, B. Pirok, S. Rutan, D. Stoll, Characterization of a High Throughput Approach for Large Scale Retention Measurement in Liquid Chromatography, Journal of Chromatography A, 2023 464182. https://doi.org/10.1016/j.chroma.2023.464182.
S.R.A. Molenaar, J.H.M. Mommers, D.R. Stoll, S. Ngxangxa, A.J. De Villiers, P.J. Schoenmakers, B.W.J. Pirok, Algorithm for tracking peaks amongst numerous datasets in comprehensive two-dimensional chromatography to enhance data analysis and interpretation, Journal of Chromatography A. 1705 2023 464223. https://doi.org/10.1016/j.chroma.2023.464223.
S.C. Rutan, K. Cash, D.R. Stoll, Experimental design and re-parameterization of the Neue-Kuss model for accurate and precise prediction of isocratic retention factors from gradient measurements in reversed phase liquid chromatography, Journal of Chromatography A 1711 2023 464443. https://doi.org/10.1016/j.chroma.2023.464443.
D.M. Makey, R.C. Diehl, Y. Xin, B.E. Murray, D.R. Stoll, B.T. Ruotolo, J.P. Grinias, A.R.H. Narayan, V. Lopez-Carillo, M. Stark, P. Johnen, R.T. Kennedy, High-Throughput Liquid Chromatographic Analysis Using a Segmented Flow Injector with a 1 s Cycle Time, Analytical Chemistry 95 2023 17028–17036. https://doi.org/10.1021/acs.analchem.3c03719.
T. Dahlseid, A. Florea, G. Schulte, K. Cash, X. Xu, P. Tattersall, Q. Wang, D. Stoll, Changes in the cis-trans isomer selectivity of a reversed-phase liquid chromatography column during use with acidic mobile phase conditions, Journal of Chromatography A 1708 2023 464371. https://doi.org/10.1016/j.chroma.2023.464371.
R.S. Van Den Hurk, M. Pursch, D.R. Stoll, B.W.J. Pirok, Recent trends in two-dimensional liquid chromatography, TrAC Trends in Analytical Chemistry 166 2023 117166. https://doi.org/10.1016/j.trac.2023.117166.
D. Stoll, M. Sylvester, D. Meston, M. Sorensen, T.D. Maloney, Development of multiple heartcutting two-dimensional liquid chromatography with ion-pairing reversed-phase separations in both dimensions for analysis of impurities in therapeutic oligonucleotides, Journal of Chromatography A 1714 2024 464574. https://doi.org/10.1016/j.chroma.2023.464574.
Boelrijk, J.; Molenaar, S. R. A.; Bos, T. S.; Dahlseid, T. A.; Ensing, B.; Stoll, D. R.; Forré, P.; Pirok, B. W. J. Enhancing LC×LC Separations through Multi-Task Bayesian Optimization. Journal of Chromatography A 2024, 1726, 464941. https://doi.org/10.1016/j.chroma.2024.464941.
Meston, D.; Maloney, T. D.; Stoll, D. Effect of Flow Rate on Plate Height and Resolution for Antisense Oligonucleotides Under Hydrophilic Interaction Liquid Chromatography Conditions. Journal of Chromatography A 2024, 465643. https://doi.org/10.1016/j.chroma.2024.465643.
Stoll, D. R.; Ghimire, A.; Sorensen, M. J.; Maloney, T. D. Does Column Length Still Matter? A Case Study of the Effect of Column Length on Resolution of Therapeutic Oligonucleotides. Journal of Chromatography A 2025, 1744, 465687. https://doi.org/10.1016/j.chroma.2025.465687.
Modelling of analyte profiles and band broadening generated by interface loops used in two-dimensional liquid chromatography operated in the first-in-first-out mode. https://doi.org/10.1016/j.chroma.2025.466425
Editorials, Expert Advice, and Opinions
Editorials, Expert Advice, and Opinions
Stoll, D. “Filters and filtration in liquid chromatography – What to do?”, LCGC North America 2017, 35 (2), 98-103.
Stoll, D.R. Column care for the long haul – Considerations for column storage, LCGC North America 2017, 35 (7), 434-439.
Dolan, J., Stoll, D., Snyder, L. How to take maximum advantage of column-type selectivity, LCGC North America 2017, 35 (9), 660-667.
Stoll, D.R., Taylor, T. Liquid Chromatography in the Global Economy - Preparing for Successful Method Transfer, LCGC North America 2017, 35 (11), 802-809.
Stoll, D.R. Resources for LC Practitioners in 2017: What’s on Your Bookshelf and in Your Web Browser?, LCGC North America 2017, 35 (12), 854-861.
Lucy, C.A., Craven, C.B., Seidl, C., Stoll, D.R. Eluent Preparation for Hydrophilic Interaction Liquid Chromatography, Part I – Solvent Volumes and Buffer Counterions, LCGC North America 2018, 36 (1), 18-24.
Rutan, S., Venkatramani, C.J., Stoll, D.R., Peak Purity in Liquid Chromatography, Part I: Basic Concepts, Commercial Software, and Limitations, LCGC North America 2018, 36 (2), 100-110.
Stoll, D.R., Seidl, C., Eluent Preparation for Hydrophilic Interaction Liquid Chromatography, Part II: pH, Buffers, and Gradient Elution, LCGC North America 2018, 36 (3), 170-177.
Cook, D., Rutan, S., Venkatramani, C.J., Stoll, D.R., Peak Purity in Liquid Chromatography, Part II: Potential of Curve Resolution Techniques, LCGC North America 2018, 36 (4), 248-255.
Stoll, D.R., Fittings and Connections for Liquid Chromatography—So Many Choices!, LCGC North America 2018, 36 (5), 304-311.
Rutan, S., Venkatramani, C.J., Stoll, D.R., Peak Purity in Liquid Chromatography, Part III: Using Two-Dimensional Liquid Chromatography, LCGC North America 2018, 36 (6), 356-361.
Fekete, S., Guillarme, D., Stoll, D.R., Tips, Tricks, and Troubleshooting for Separations of Biomolecules, Part I: Contemporary Reversed-Phase Protein Separations, LCGC North America 2018, 36 (7), 440-447.
Stoll, D., Contaminants Everywhere! Tips and Tricks for Reducing Background Signals When Using LC–MS, LCGC North America 2018, 36 (8), 498-505.
Fekete, S., Guillarme, D., Stoll, D.R., Tips, Tricks, and Troubleshooting for Separations of Biomolecules, Part II: Contemporary Separations of Proteins by Size-Exclusion Chromatography, LCGC North America 2018, 36 (9), 662-667, 702.
Stoll, D.R., Mixing and Mixers in Liquid Chromatography—Why, When, and How Much? Part I, The Pump, LCGC North America 2018, 36 (10), 746-751.
Stoll, D.R., Troubleshooting for Two-Dimensional Liquid Chromatography: Breakthrough in the Second Dimension, LCGC North America 2018, 36 (11), 597-600.
Stoll, D.R., Letting the Chromatograph Talk, Part I: Looking for Troubleshooting Clues in Unexpected Places, LCGC North America 2018, 36 (12), 860-866.
Stoll, D.R., What’s Trending in LC Troubleshooting?, LCGC North America 2019, 37 (1), 18-23.
Stoll, D.R., Reversed-Phase Liquid Chromatography and Water, Part I: How Much is Too Much?, LCGC North America 2019, 37 (2), 80-90.
Stoll, D.R., Looking for New Selectivity in Reversed-Phase Liquid Chromatography? A View of the Selectivity Landscape Over the Past Two Years, LCGC North America 2019, 37 (3), 168-172.
Stoll, D.R., Reversed-Phase Liquid Chromatography and Water, Part II: Re-equilibration of the Stationary Phase Following Gradient Elution, LCGC North America 2019, 37 (4), 244-249.
Stoll, D.R., Taylor, T., Methods from Mars? Coping with Chromatographic Legacies, LCGC North America 2019, 37 (5), 292-296.
Breitbach, Z., Randstrom, C., Chang, J., Lesslie, M., Webster, G., Stoll, D.R., Mixing and Mixers in Liquid Chromatography, Part III: Solutions for Problems with Sample Diluents, LCGC North America 2019, 37 (6), 368-373.
Stoll, D.R., Makey, D., Mobile Phase Buffers in LC: Effect of Buffer Preparation Method on Retention Repeatability, LCGC North America 2019, 37 (7), 444-449.
Stoll, D.R., Pass the Salt: Evolution of Coupling Ion-Exchange Separations and Mass Spectrometry, LCGC North America 2019, 37 (8), 504-508.
Stoll, D.R., Mack, A., Mind the Diluent: Effects of Sample Diluent on Analyte Recovery in Reversed-Phase and HILIC Separations, LCGC North America 2019, 37 (9), 670-675.
Stoll, D.R., Column Re-equilibration Following Gradient Elution: How Long is Long Enough? Part I: Reversed-phase and HILIC Separations of Small Molecules, LCGC North America 2019, 37 (11), 790-795.
Stoll, D.R., Effects of Flow Rate on UV Detection in Liquid Chromatography, LCGC North America 2019, 37 (12), 846-850.
Stoll, D.R., Lauer, T.J., Effects of Buffer Capacity in Reversed-Phase Liquid Chromatography, Part I: Relationship Between the Sample- and Mobile-Phase Buffers, LCGC North America 2020, 38 (1), 10-15.
Stoll, D.R., Lauer, T.J., Effects of Buffer Capacity in LC, Part II: Visualization of pH Changes Inside the Column, LCGC North America 2020, 38 (2), 70-74.
Hsiao, J., Staples, G.O., Stoll, D.R., Troubleshooting LC Separations of Biomolecules, Part I: Background, and the Meaning of Inertness, LCGC North America 2020, 38 (3), 146-150.
Stoll, D.R., Selectivity in Reversed-Phase Liquid Chromatography: 20 Years of the Hydrophobic Subtraction Model, LCGC North America 2020, 38 (4), 205-210.
Stoll, D.R., Liquid Chromatography at Room Temperature: When Should the Column Temperature Be Specified in a Method?, LCGC North America 2020, 38 (5), 261-268.
Stoll, D.R., Taylor, T., Recovering from a COVID-19 Shutdown: Tips and Tricks for Starting Up, Part I, LCGC North America 2020, 38 (6), 320-324.
Stoll, D.R., Taylor, T., Recovering from a COVID-19 Shutdown: Tips and Tricks for Starting Up, Part II, LCGC North America 2020, 38 (7), 379-384.
Hsiao, J., Chu, T., Potter, O., Staples, G.O., Stoll, D.R., Troubleshooting LC Separations of Biomolecules, Part II: Passivation and Mobile-Phase Additives, LCGC North America 2020, 38 (8), 431-434.
Stoll, D.R., Rules of Thumb for Reversed-Phase LC: What’s In Your Chromatographic Mind?, LCGC North America 2020, 38 (9), 480-485.
Stoll, D.R., Troubleshooting 101: Some Essential Principles of Effective Troubleshooting, LCGC North America 2020, 38 (10), 544-547.
Stoll, D.R., Troubleshooting for Two-Dimensional Liquid Chromatography: Breakthrough in the Second Dimension, LCGC North America 2020, 38 (11), 597-600.
Haidar Ahmad, I., Stoll, D.R., Tips for Liquid Chromatography Coupled with Charged Aerosol Detection, LCGC North America 2020, 38 (12), 648-653.
Stoll, D.R., LC Troubleshooting Odds and Ends from 2020, LCGC North America 2021, 39 (1), 10-14.
Stoll, D.R., Surfing on Mobile Phase, Part I: Origins of Mobile-Phase Composition Waves and Their Effects on Detector Baselines, LCGC North America 2021, 39 (2), 52-55.
Stoll, D.R., Surfing on Mobile Phase, Part II: Impact of Mobile-Phase Composition Waves on Retention in LC, LCGC North America 2021, 39 (3), 117-119, 149.
Stoll, D.R., Broeckhoven, K., Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part I: Basic Concepts, LCGC North America 2021, 39 (4), 159-166.
Stoll, D.R., Broeckhoven, K., Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part II: Sample Injection, LCGC North America 2021, 39 (5), 208-212.
Stoll, D.R., Broeckhoven, K., Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part III: Tubing and Detectors, LCGC North America 2021, 39 (6), 252-257.
Stoll, D.R., Lauer, T.J., Broeckhoven, K., Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part IV: Gradient Elution, Flow Splitting, and a Holistic View, LCGC North America 2021, 39 (7), 308-314.
Stoll, D.R., But My Peaks Are Not Gaussian! Part I: Basic Concepts in Peak Shape, and the Effect of Extracolumn Connections, LCGC North America 2021, 39 (8), 353-362.
Stoll, D.R., But My Peaks Are Not Gaussian! Part II: Physical Causes of Peak Asymmetry, LCGC North America 2021, 39 (9), 409-412.
Stoll, D.R., Kempen, T., Retention Factor Is Independent of Pressure in LC, Right?, LCGC North America 2021, 39 (10), 471-477.
McCalley, D., Stoll, D.R., But My Peaks Are Not Gaussian! Part III: Physicochemical Causes of Peak Tailing, LCGC North America 2021, 39 (11), 526-531, 539.
Stoll, D.R., Essentials of LC Troubleshooting, Part I: Pressure Problems, LCGC North America 2021, 39 (12), 572-574, 585.
Broeckhoven, K., Stoll, D.R., But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part I: Basic Concepts, LCGC North America 2022, 40 (1), 9-12.
Broeckhoven, K., Stoll, D.R., But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part II: Making and Interpreting the Plots, LCGC North America 2022, 40 (2), 58-62.
Broeckhoven, K., Gunnarson, C., Stoll, D.R., But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part III: Pulling It All Together, LCGC North America 2022, 40 (3), 111-115.
Stoll, D.R., Essentials of LC Troubleshooting, Part II: Misbehaving Retention Times, LCGC North America 2022, 40 (4), 151-155.
Stoll, D., Pirok, B. Hot Topics in HPLC, Part V: Exciting New Developments in Two-Dimensional Liquid Chromatography, LCGC online, May 12, 2020. http://www.chromatographyonline.com/hot-topics-hplc-part-v-exciting-new-developments-two-dimensional-liquid-chromatography.
Stoll, D.R., Essentials of LC Troubleshooting, Part III: Those Peaks Don’t Look Right, LCGC North America 2022, 40 (6), 244-247.
Baghdady, Y., Stoll, D.R., Development of a System Suitability Test for Two-Dimensional Liquid Chromatography, LCGC North America 2022, 40 (7), 292-295.
Stoll, D.R., Essentials of LC Troubleshooting, Part IV: What Is Going On with the Baseline?, LCGC North America 2022, 40 (8), 338-342.
Metzger, B., Shoykhet, K., Buckenmaier, S., Stoll, D.R., Chemistry in a Bottle: Ester Formation in Acidified Mobile-Phase Solvents, LCGC North America 2022, 40 (9), 411-416.
Stoll, D.R., Essentials of LC Troubleshooting, Part V: What Happened to My Sensitivity?, LCGC North America 2022, 40 (10), 471-475, 483.
Meston, D., Stoll, D.R., Pitfalls in Proteomics: Avoiding Problems That Can Occur Before Data Acquisition Begins, LCGC North America 2022, 40 (11), 524-528.
Stoll, D.R., Essentials of LC Troubleshooting, VI: How Wide Should Those Peaks Be?, LCGC North America 2022, 40 (12), 562-565, 578.
Stoll, D.R., What Are My Options to Improve My Separation? Part I: Foundational Concepts, LCGC North America 2023, 41 (1), 8-12.
Stoll, D.R., What are Options to Improve My Separation? Part II: Likelihood of Separation, Adjusting Selectivity for Simple Mixtures, LCGC North America 2023, 41 (2), 44-49, 62.
Cash, K., Seid, E., Dahlseid, T., Stoll, D.R., Essentials of LC Troubleshooting, Part II, Continued: More Misbehaving Retention Times, LCGC North America 2023, 41 (3), 90-94.
Stoll, D.R., What Are Options to Improve My Separation? Part III: Options to Consider to Improve Resolution of Complex Mixtures, LCGC North America 2023, 41 (4), 124-128, 136.
Stoll, D.R., Initiating Method Development with Scouting Gradients—Where to Begin and How to Proceed?, LCGC North America 2023, 41 (5), 160-165.
Stoll, D.R., What Are Options to Improve My Separation? Part IV: Solutions to Consider for Improving Separation Speed, LCGC North America 2023, 41 (6), 202-205.
Stoll, D.R., Strongly Adsorbing Analytes: What, Why, and How to Fix It, LCGC North America 2023, 41 (7), 242-244.
Stoll, D.R., The Evolution of LC Troubleshooting: Protective Devices and Column Repair, LCGC North America 2023, 41 (8), 316-319.
Stoll, D.R., The Evolution of LC Troubleshooting: Degassing, LCGC North America 2023, 41 (9), 368-371.
Stoll, D.R., The Evolution of LC Troubleshooting: Strategies for Improving Peak Tailing, LCGC North America 2023, 41 (10), 404-408.
Stoll, D.R., Troubleshooting Odds and Ends to Close Out 2023: Questions from the Mailbag, and Second Opinions, LCGC North America 2023, 41 (11), 442-445.
Stoll, D.R., The Gradient Delay Volume, Part I: Theory, LCGC International 2024, 1 (1), 6-10.
Stoll, D.R., The Gradient Delay Volume, Part II: Practice – Effects on Method Transfer, LCGC International 2024, 1 (2), 6-10. https://doi.org/10.56530/lcgc.int.ia2675s7.
Stoll, D.R., The Gradient Delay Volume, Part III: Practice – Effects on Throughput, LCGC International 2024, 1 (3), 6-11. https://doi.org/10.56530/lcgc.int.ha5479i5.
Stoll, D.R., Grinias, J.P., Treat it Like a Circuit, Part I: Comparison of Concepts from Electronics to Flow in LC Systems, LCGC International 2024, 1 (4), 6-10. https://doi.org/10.56530/lcgc.int.ol2372p5.
Stoll, D.R., Grinias, J.P., Treat It Like a Circuit, Part II: Applications and Troubleshooting, LCGC International 2024, 1 (5), 6-12. https://doi.org/10.56530/lcgc.int.wy6073a3.
Stoll, D.R. Eyes on the Prize: Overcoming Uncertainty to Realize the Power of 2D-LC Separations, LCGC International 2024, 1 (6), 6-9. https://doi.org/10.56530/lcgc.int.ku8278q2.
Tsay, F-R., Henderson, D., Aldine, F., Stoll, D., Ahmad, I.A.H., Chromatographic Isolation of Sensitive Compounds: Challenges and Solutions, LCGC International 2024, 1 (7), 6-10. https://doi.org/10.56530/lcgc.int.pu7482t9.
Lin, Z., Wang, Q., Stoll, D., In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions, LCGC International 2024, 1 (8), 6-11. https://doi.org/10.56530/lcgc.int.ag7666q9.
Stoll, D.R., What’s New in Reversed-Phase Liquid Chromatography Selectivity? An Update from the Perspective of the Hydrophobic Subtraction Model, LCGC International 2024, 1 (9), 6-9. https://doi.org/10.56530/lcgc.int.op9974p8.
Stoll, D.R., Mobile Phase Buffers in Liquid Chromatography: A Review of Essential Ideas, LCGC International 2024, 1 (10), 6-11. https://doi.org/10.56530/lcgc.int.ug8880n3.
Stoll, D.R., Sontowski, E., Mobile Phase Buffers in Liquid Chromatography: The Buffer–Detector Battle, LCGC International 2025, 2 (1), 8-11. https://doi.org/10.56530/lcgc.int.iq2371m6.
Stoll, D.R., Matrix Effects on Quantitation in Liquid Chromatography: Sources and Solutions, LCGC International 2025, 2 (2), 8-14. https://doi.org/10.56530/lcgc.int.op2777i2
Stoll, D.R., Troubleshooting Everywhere! An Assortment of Topics from Pittcon 2025, LCGC International 2025, 2 (3), 8-11. https://doi.org/10.56530/lcgc.int.bw1277b4
Stoll, D.R., Essentials of Troubleshooting, Part VII: How Wide Should Those Peaks Be? (Large Molecule Edition), LCGC International 2025, 2 (5), 26-29. https://doi.org/10.56530/lcgc.int.zu2182c7
Stoll, D.R., Essentials of LC Troubleshooting, VIII: A Deeper Look Into Column Efficiency, LCGC International 2025, 2 (6), 8-13. https://doi.org/10.56530/lcgc.int.vk3573q9
Gilar, M., Stoll, D.R., Challenges and Solutions in Oligonucleotide Analysis, Part I: An Overview of Liquid Chromatography Methods and Applications, LCGC International 2025, 2 (7).
Stoll, D.R., Onboarding New LC Users: A Top Ten List, LCGC International 2025, 2 (8).
Gilar, M., Stoll, D.R., Challenges and Solutions in Oligonucleotide Analysis, Park II: A Detailed Look at Ion-Pairing Reversed-Phase Separations, LCGC International 2026, 2 (9).
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