Research

Identifying therapeutic combinations in brain cancer

• We are using cerebellar granule cell progenitors (GCPS) to model cell cycle exit in the nervous system. Our time series models of GCP cell cycle exit have identified targets in medulloblastoma and neurite outgrowth.

• We are utilizing The Cancer Genome Atlas (TCGA) data and information from the Library of Integrated Cell Signatures (LINCS) consortium to identify therapeutic combinations in glioblastoma.