Publications
Recent Publications
Yang H, Sui P, Guo Y, Chen S, Maloof ME, Ge G, Nihozeko F, Delma CR, Zhu G, Zhang P, Ye Z, Medina EA, Ayad NG, Mesa R, Nimer SD, Chiang CM, Xu M, Chen Y, Yang FC. Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping. EMBO Rep. 2023 Oct 9;24(10):e57032. doi: 10.15252/embr.202357032. Epub 2023 Aug 31. PMID: 37650863
Walter TJ, Suter RK, Ayad NG. An overview of human single-cell RNA sequencing studies in neurobiological disease. Neurobiol Dis. 2023 Aug;184:106201. doi: 10.1016/j.nbd.2023.106201. Epub 2023 Jun 13. PMID: 37321420
Yang F, Rodriguez-Blanco J, Long J, Swiderska-Syn M, Wynn DT, Li B, Shen C, Nayak A, Ban Y, Sun X, Suter RK, McCrea HJ, Capobianco AJ, Ayad NG, Robbins DJ. A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth. Mol Cancer Res. 2022 Nov 3;20(11):1598-1610. doi: 10.1158/1541-7786.MCR-22-0182. PubMed PMID: 35925047; PubMed Central PMCID: PMC9633409.
Cerqueira SR, Benavides S, Lee HE, Ayad NG, Lee JK. BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion. Exp Neurol. 2022 Jun;352:114035. doi: 10.1016/j.expneurol.2022.114035. Epub 2022 Mar 9. PubMed PMID: 35276206.
Govindarajan V, Shah AH, Di L, Rivas S, Suter R, Eichberg DG, Luther E, Lu V, Morell AA, Ivan ME, Komotar RJ, Ayad N, De La Fuente M. Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma. World Neurosurg. 2022 Mar 18:S1878-8750(22)00341-2. doi: 10.1016/j.wneu.2022.03.051. Epub ahead of print. PMID: 35314408.
Cerqueira SR, Benavides S, Lee HE, Ayad NG, Lee JK. BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion. Exp Neurol. 2022 Mar 9;352:114035. doi: 10.1016/j.expneurol.2022.114035. Epub ahead of print. PMID: 35276206.
Rybin, M. J., Laverde-Paz, M. J., Suter, R. K., Affer, M., Ayad, N. G., Feng, Y., & Zeier, Z. (2022). A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorganic & Medicinal Chemistry Letters, 61, 128614. https://doi.org/10.1016/j.bmcl.2022.128614
Shah AH, Suter R, Gudoor P, Doucet-O'Hare TT, Stathias V, Cajigas I, de la Fuente M, Govindarajan V, Morell AA, Eichberg DG, Luther E, Lu VM, Heiss J, Komotar RJ, Ivan ME, Schurer S, Gilbert MR, Ayad NG. A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines. Neurooncol Adv. 2022 Jan-Dec;4(1):vdab192. doi: 10.1093/noajnl/vdab192. eCollection 2022 Jan-Dec. PubMed PMID: 35118385; PubMed Central PMCID: PMC8807341.
Jermakowicz AM, Rybin MJ, Suter RK, Sarkaria JN, Zeier Z, Feng Y, Ayad NG. The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion. Sci Rep. 2021 Dec 3;11(1):23370. doi: 10.1038/s41598-021-02584-6. PMID: 34862404; PMCID: PMC8642539.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z. PubMed PMID: 34489457.
Rybin MJ, Ivan ME, Ayad NG, Zeier Z. Organoid Models of Glioblastoma and Their Role in Drug Discovery. Front Cell Neurosci. 2021;15:605255. doi: 10.3389/fncel.2021.605255. eCollection 2021. Review. PubMed PMID: 33613198; PubMed Central PMCID: PMC7892608.
Suter RK, Rodriguez-Blanco J, Ayad NG. Epigenetic pathways and plasticity in brain tumors. Neurobiol Dis. 2020 Nov;145:105060. doi: 10.1016/j.nbd.2020.105060. Epub 2020 Aug 30. Review. PubMed PMID: 32877743.
Cerqueira SR, Ayad NG, Lee JK. Neuroinflammation Treatment via Targeted Delivery of Nanoparticles. Front Cell Neurosci. 2020;14:576037. doi: 10.3389/fncel.2020.576037. eCollection 2020. Review. PubMed PMID: 33192321; PubMed Central PMCID: PMC7555434.
Kannan-Sundhari A, Abad C, Maloof ME, Ayad NG, Young JI, Liu XZ, Walz K. Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654. doi: 10.3389/fcell.2020.576654. eCollection 2020. PubMed PMID: 33015071; PubMed Central PMCID: PMC7509448.
Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG. Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis. Nat Commun. 2019 Jul 10;10(1):3028. doi: 10.1038/s41467-019-10799-5. PubMed PMID: 31292434; PubMed Central PMCID: PMC6620341.
Winterbottom EF, Moroishi Y, Halchenko Y, Armstrong DA, Beach PJ, Nguyen QP, Capobianco AJ, Ayad NG, Marsit CJ, Li Z, Karagas MR, Robbins DJ. Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner. Environ Health. 2019 Feb 28;18(1):18. doi: 10.1186/s12940-019-0455-9. PubMed PMID: 30819207; PubMed Central PMCID: PMC6396530.
Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 Feb 15;25(4):1379-1388. doi: 10.1158/1078-0432.CCR-18-1319. Epub 2018 Nov 28. PubMed PMID: 30487124; PubMed Central PMCID: PMC7142219.
Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG. Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nat Commun. 2018 Dec 14;9(1):5315. doi: 10.1038/s41467-018-07659-z. PubMed PMID: 30552330; PubMed Central PMCID: PMC6294341.
Chin C, Lunking ES, de la Fuente M, Ayad NG. Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme. Front Oncol. 2018;8:521. doi: 10.3389/fonc.2018.00521. eCollection 2018. Review. PubMed PMID: 30483476; PubMed Central PMCID: PMC6243054.
Rudman MD, Choi JS, Lee HE, Tan SK, Ayad NG, Lee JK. Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury. Exp Neurol. 2018 Nov;309:181-192. doi: 10.1016/j.expneurol.2018.08.005. Epub 2018 Aug 19. PubMed PMID: 30134146.