RESEARCH AND SCHOLARLY ACTIVITIES 

PUBLICATIONS

1. Lipschutz S., Kim Y, Curtis M, Friedrich L, Alimperti S. Development of multiparametric bioprinting method for generation of 3D printed cell-laden structures. Biotechnol Prog (Accepted) (IF: 2.9) 

2. Lee EJ, Lialios P, Curtis M, Kim Y, Williams J, Salipante P, Hudson S, Esch M, Levi M, Kitlinska J, Alimperti S. Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms, Advanced Healthcare Materials (Accepted) (IF: 10.0)

3. Lialios P, Alimperti S. Role of E-Cadherin in Epithelial Barrier Dysfunction: Implications for Bacterial Infection, Inflammation, and Disease Pathogenesis. Frontiers in Cellular and Infection Microbiology (Accepted) (IF: 4.6)

4. Serafini R, Curtis M, Alimperti S. Intellectual Property Management Training Should be Embedded in the Biomedical Education Process. Nature Biotechnology (Accepted) (IF: 33.1)

5. Patil R, Alimperti S. Graphene in 3D Bioprinting. J Funct Biomater. 2024;15(4). Epub 2024/04/26. doi: 10.3390/jfb15040082. PubMed PMID: 38667539; PMCID: PMC11051043.  (IF: 5.0)

6. Yang B, Alimperti S, Gonzalez MV, Dentchev T, Kim M, Suh J, Titchenell PM, Ko KI, Seykora J, Benakanakere M, Graves DT. Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors. Diabetes. 2024;73(1):120-34. Epub 2023/10/24. doi: 10.2337/db23-0258. PubMed PMID: 37874683; PMCID: PMC10784658 were reported.  (IF: 7.7)

7. Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proc Natl Acad Sci U S A. 2023;120(41):e2308941120. Epub 2023/10/02. doi: 10.1073/pnas.2308941120. PubMed PMID: 37782785; PMCID: PMC10576061. (IF: 12.7)

8. Lee, E.J., P. Salipante, A. Kotula, S. Lipshutz, D.T. Graves and Alimperti S. “Mechanical Regulation of  Oral epithelial barrier function” , Bioengineering,  https://doi.org/10.3390/bioengineering10050517. (IF: 5.1) * Cover Story at Bioengineering: https://www.mdpi.com/2306-5354/10/5

9. Kim Y, Lee EJ, Kotula AP, Takagi S, Chow L, Alimperti S. Engineering 3D Printed Scaffolds with Tunable Hydroxyapatite. J Funct Biomater. 2022;13(2). Epub 2022/04/26. doi: 10.3390/jfb13020034. PubMed PMID: 35466216; PMCID: PMC9036238. (IF: 5.0)

10. Kim Y, Alimperti S, Choi P, Noh M. An Inkjet Printed Flexible Electrocorticography (ECoG) Microelectrode Array on a Thin Parylene-C Film. Sensors (Basel). 2022;22(3). Epub 2022/02/16. doi: 10.3390/s22031277. PubMed PMID: 35162023; PMCID: PMC8838719. (IF: 3.7)

11.  Salipante PF, Hudson SD, Alimperti S. Blood vessel-on-a-chip examines the biomechanics of microvasculature. Soft Matter. 2021;18(1):117-25. Epub 2021/11/25. doi: 10.1039/d1sm01312b. PubMed PMID: 34816867; PMCID: PMC9001019. (IF: 4.1)

12.  Lee EJ, Jain M, Alimperti S. Bone Microvasculature: Stimulus for Tissue Function and Regeneration. Tissue Eng Part B Rev. 2021;27(4):313-29. Epub 2020/09/18. doi: 10.1089/ten.TEB.2020.0154. PubMed PMID: 32940150; PMCID: PMC8390780. (IF: 5.2)

13. Kim Y, Lee EJ, Davydov AV, Frukhtbeyen S, Seppala JE, Takagi S, Chow L, Alimperti S. Biofabrication of 3D printed hydroxyapatite composite scaffolds for bone regeneration. Biomed Mater. 2021;16(4). Epub 2020/12/01. doi: 10.1088/1748-605X/abcf03. PubMed PMID: 33254152; PMCID: PMC8164647. (IF: 4.1) 

14. Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Sci Adv. 2019;5(8):eaav6789. Epub 2019/09/07. doi: 10.1126/sciadv.aav6789. PubMed PMID: 31489365; PMCID: PMC6713506. (IF: 11.5) 

15. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 2019;33(1):132-47. Epub 2018/06/28. doi: 10.1038/s41375-018-0178-x. PubMed PMID: 29946193; PMCID: PMC6327052.

16. McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA. Inhibition of alphavbeta5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2017;28(6):1741-52. Epub 2017/01/08. doi: 10.1681/ASN.2016020200. PubMed PMID: 28062569; PMCID: PMC5461783. (IF: 10.2) 

17. Dang LTH, Aburatani T, Marsh GA, Johnson BG, Alimperti S, Yoon CJ, Huang A, Szak S, Nakagawa N, Gomez I, Ren S, Read SK, Sparages C, Aplin AC, Nicosia RF, Chen C, Ligresti G, Duffield JS. Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury. Biomaterials. 2017;141:314-29. Epub 2017/07/18. doi: 10.1016/j.biomaterials.2017.07.010. PubMed PMID: 28711779; PMCID: PMC5567800. (IF: 15.3)

18. Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS. Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Proc Natl Acad Sci U S A. 2017;114(33):8758-63. Epub 2017/08/03. doi: 10.1073/pnas.1618333114. PubMed PMID: 28765370; PMCID: PMC5565405. (IF: 12.7)

19. Row S, Liu Y, Alimperti S, Agarwal SK, Andreadis ST. Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics. J Cell Sci. 2016;129(15):2950-61. Epub 2016/06/18. doi: 10.1242/jcs.183772. PubMed PMID: 27311482; PMCID: PMC5004872. (IF: 5.2)

20. Alimperti S, Andreadis ST. CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem Cell Res. 2015;14(3):270-82. Epub 2015/03/17. doi: 10.1016/j.scr.2015.02.002. PubMed PMID: 25771201; PMCID: PMC4439315. (IF: 2.2)

21. Alimperti S, You H, George T, Agarwal SK, Andreadis ST. Cadherin-11 regulates both mesenchymal stem cell differentiation into smooth muscle cells and the development of contractile function in vivo. J Cell Sci. 2014;127(Pt 12):2627-38. Epub 2014/04/18. doi: 10.1242/jcs.134833. PubMed PMID: 24741067; PMCID: PMC4058109.(IF: 5.2)

22. Alimperti S, Lei P, Wen Y, Tian J, Campbell AM, Andreadis ST. Serum-free spheroid suspension culture maintains mesenchymal stem cell proliferation and differentiation potential. Biotechnol Prog. 2014;30(4):974-83. Epub 2014/03/13. doi: 10.1002/btpr.1904. PubMed PMID: 24616445; PMCID: PMC5081183.(IF: 2.6) 

23. Alimperti S, Lei P, Tian J, Andreadis ST. A novel lentivirus for quantitative assessment of gene knockdown in stem cell differentiation. Gene Ther. 2012;19(12):1123-32. Epub 2012/01/14. doi: 10.1038/gt.2011.208. PubMed PMID: 22241174. (IF: 4.1)

24. Tian J, Alimperti S, Lei P, Andreadis ST. Lentiviral microarrays for real-time monitoring of gene expression dynamics. Lab Chip. 2010;10(15):1967-75. Epub 2010/06/04. doi: 10.1039/c003153d. PubMed PMID: 20520864. (IF: 7.5)

PATENTS

1.  U.S. Patent Application 2021/0260249 “Three-dimensional printed hydroxyapatite composite scaffolds for bone regeneration, precursor compositions and methods of printing.” 

Link to: https://patents.google.com/patent/US20220401624A1/en

 RESEARCH FUNDING

      NIH/NCI -  R21CA294025 

Title of Project: 3D bioengineered microfluidic platform for research on Ewing sarcoma bone metastasis

Dates of Project Period: 07/01/2024- 06/30/2026

      Role: PI 

     Georgetown-Lombardi Center- Cancer Cell Biology (CCB) Program Pilot Fund Award

Title of Project: 3D in vitro model for testing Ewing sarcoma mechanisms of bone metastasis 

Dates of Project Period: 07/01/2024- 05/31/2025

Role: PI

     National Science Foundation

     Title: MRI: Track 1 Acquisition of a 3-Dimensional Nanolithography Instrument

     Funded June 2023

     Role: Co-PI

NIH/NIDCR - R01 DE031046

Title of Project: Regulation of epithelial barrier

Dates of Project Period: 08/10/2021- 05/31/2026

Role: PI

NIH/NIAMS - R21 AR076497

Title of Project: Engineering 3D biomimetic osteogenesis imperfecta models to dissect mechanisms of N-cadherin mediated osteoblast-endothelial function

Dates of Project Period: 09/01/2020- 07/15/2022

Role: PI

American Dental Association Foundation -9725000

Title of Project: Engineering oral tissue on-a chip models to study diabetic periodontal diseases.

Dates of Project Period: 07/01/2018- 07/01/2021

Role: PI