Publications
For a complete list, see Google Scholar
Embedded Files
Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling. Nicholas C Vierra, Luisa Ribeiro-Silva, Michael Kirmiz, Deborah van der List, Pradeep Bhandari, Olivia A Mack, James Carroll, Elodie Le Monnier, Sue A Aicher, Ryuichi Shigemoto, James S Trimmer. Nature Communications, 2023
We showed that a specialized protein kinase A (PKA) anchoring protein called SPHKAP directs PKA to ER-PM junctions in brain neurons, allowing for the reciprocal regulation of PKA and Ca2+ signaling.
Regulation of neuronal excitation–transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM junctions. Nicholas C Vierra, Samantha C O’Dwyer, Collin Matsumoto, L Fernando Santana, James S Trimmer. Proceedings of the National Academy of Sciences, 2021
A specific domain on Kv2.1 voltage-gated K+ channels promotes clustering of L-type Cav1.2 Ca2+ channels at ER-PM junctions, supporting depolarization-induced excitation-transcription coupling in hippocampal neurons.
Kv2. 1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons. Nicholas C Vierra, Michael Kirmiz, Deborah Van Der List, L Fernando Santana, James S Trimmer. eLife, 2019
We showed that Kv2.1 voltage-gated K+ channels play a structural role juxtaposing plasma membrane L-type Ca2+ channels with ER ryanodine receptor Ca2+ channels, providing a mechanism for compartmentalized Ca2+ signaling in the soma.
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