Brain neurons use electrical signals to communicate. These signals can powerfully modify neuronal function. We study how neurons decipher electrical signals and transform them into a form recognized by the intracellular signaling pathways that support the overall function and adaptability of the neuron.

Our research takes a multi-disciplinary approach, combining techniques such as electrophysiology and fluorescence microscopy with biochemical methods, including protein mass spectrometry and the generation and use of novel antibodies. We use these approaches to define the molecular mechanisms that couple neuronal firing to fundamental cellular processes including gene expression, metabolism, and ion channel function.