Publications

W. Lee, D.K. Hwang, H.Y. Kim, D.A. Brenner. Precision pathophysiology in steatotic liver disease. Clinical and Molecular Hepatology. Epub ahead of print.

S. Sakane, T. Nishio, H. Fuji, S.Y. Park, K. Ishizuka, C. Miciano, Y. Kimura, M. Hosseini, K. Diggle, V. Zhang, W. Lee, H.Y. Kim, X. Liu, A. Wang, D.A. Brenner, T. Kisseleva. Msln/Muc16 signaling in activated Portal Fibroblasts drives the development of cholestatic fibrosis and HCC in aged female Mdr2-/-mice. Cellular and Molecular Gastroenterology and Hepatology. 101785

H.Y. Kim, O. Mizrahi, W. Lee, S.B. Rosenthal, C. Han, B.A. Yee, S.M. Blue, J. Diaz, J. Jonnalagadda, K. Hokutan, H. Jang, C.-T. Ma, A. Bobkov, E. Sergienko, M.R. Jackson, B. Stefanovic, T. Kisseleva, G.W. Yeo, D.A. Brenner. RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis. The Journal of Clinical Investigation. 136(8):e197923

W. Lee, X. Liu, S.B. Rosenthal, C. Miciano, S. Chakraborty, D. Dhar, H.Y. Kim, D.A. Brenner, T. Kisseleva. Deletion of ETS1 in hepatic stellate cells accelerates development of liver fibrosis. JCI insight. 10(24):e195242 

H.Y. Kim¶, W. Lee¶, X. Liu, H. Jang, S. Sakane, R.C-G. Weber, K. Diggle, S.A. Kerk, C.M. Metallo, T. Kisseleva, D.A. Brenner. Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress. STAR Protocols. 5(2):103111

H.Y. Kim, S.B. Rosenthal, X. Liu, C. Miciano, X. Hou, M. Miller, J. Buchanan, O.B. Poirion, D.C. Fuentes, C. Han, M. Housseini, R.C.G. Weber, S. Sakane, W. Lee, H. Zhao, K. Diggle, S. Preissl, C.K. Glass, B. Ren, A. Wang, D.A. Brenner, T. Kisseleva. Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease. Journal of Hepatology. 82(5):882-897

G. Yamamoto, R.C.G. Weber, W. Lee, V. Zhang, H. Jang, S. Sakane, X. Liu, H.Y. Kim, D.A. Brenner, N. Li, T. Kisseleva. DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids. JHEP Reports. 7(7):101415 

Y.J. Choi, Y.A. Nam, J.Y. Hyun, J. Yu, Y. Mun, S.H. Yun, W. Lee, C.J. Park, B.W. Han, B.H. Lee. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis. Autophagy. 21(4):827-839

N.A. Osna, I. Tikhanovich, M. Ortega-Ribera, S. Mueller, C. Zheng, J. Mueller, S. Li, S. Sakane, R.C.G. Weber, H.Y. Kim, W. Lee, S. Ganguly, Y. Kimura, X. Liu, D. Dhar, K. Diggle, D.A. Brenner, T. Kisseleva, N. Attal, I.H. Mckillop, S. Chokshi, R. Mahato, K. Rasineni, G. Szabo, K.K. Kharbanda. Alcohol-associated liver disease outcomes: critical mechanisms of liver injury progression. Biomolecules. 14(4):404 

H.Y. Kim, S. Sakane, A. Eguileor, R.C.G. Weber, W. Lee, X. Liu, K. Lam, K. Ishizuka, S.B. Rosenthal, K. Diggle, D.A. Brenner, T. Kisseleva. The origin and fate of liver myofibroblasts. Cellular and Molecular Gastroenterology and Hepatology. 17(1):93-106

W. Lee, H.Y. Kim, Y.J. Choi, S.H. Jung, Y.A. Nam, Y. Zhang, S.H. Yun, T.S. Chang, B.H. Lee. SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation. Theranostics. 12(5): 2351-2369

W. Lee, Y. Mun, K.Y. Lee, J.M. Park, T.S. Chang, Y.J. Choi, B.H. Lee. Mefenamic acid-upregulated Nrf2/SQSTM1 protects hepatocytes against oxidative stress-induced cell damage. Toxics. 11(9):735

Y.J. Choi, S.H. Yun, J. Yu, Y. Mun, W. Lee, C.J. Park, B.W. Han, B.H. Lee. Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1. Molecular Metabolism. 76:101784

Y.J. Choi, H.S. Yang, Y. Zhang, W. Lee, S.H. Yun, Y.A. Nam, G. Lee, B.H. Jung, T.S. Chang, K. Lee, B.H. Lee. Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver. Ecotoxicology and Environmental Safety. 247:114213

H.Y. Kim, G.H. Baek, W. Lee, Y.J. Lee, W. Shim, Y.J. Choi, B.H. Lee, S.K. Kim, K.W Kang. CD44 is involved in liver regeneration through enhanced uptake of extracellular cystine. Clinical and Translational Medicine. 12(5):e873

Y.J. Choi, G. Lee, S.H. Yun, W. Lee, J. Yu, S.K. Kim, B.H. Lee. The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation. Amino Acids. 54(5):823-834

S.H. Jung, W. Lee, S.H. Park, K.Y. Lee, Y.J. Choi, S.H. Choi, D.M. Kang, T.S. Chang, S.S. Hong, B.H. Lee. Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity. Redox Biology. 37:101751

W.C. Sim, W. Lee, H. Sim, K.Y. Lee, S.H. Jung, Y.J. Choi, H.Y. Kim, K.W. Kang, J.Y. Lee, Y.J. Choi, S.K. Kim, D.W. Jun, W. Kim, B.H. Lee. Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. Metabolism 102:154000

W.C. Sim, D.G. Kim, W. Lee, H. Sim, Y.-J. Choi, B.-H. Lee.Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. Cell Biology and Toxicology. 35(5):457-470

K.Y. Lee, W. Lee, S.H. Jung, J.M. Park, H. Sim, Y.J. Choi, Y.J. Park, Y. Chung, B.H. Lee. Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice. Biochemical Pharmacology. 166:46-55

W.C. Sim, I. Han, W. Lee, Y.-J. Choi, D.G. Kim, S.H. Jung, S.H. Oh, B.H. Lee. Inhibition of homocysteine-induced endoplasmic reticulum stress and endothelial cell damage by l-serine and glycine. Toxicology in vitro. 34:138-145

W. Lee, H.R. Koo, Y.J. Choi, J.G. Choi, M.S. Oh, X. Jin, M. Choo, S. Park, Y.S. Jeong, S.J. Chung, B.H. Lee. Z-ligustilide and n-butylidenephthalide isolated from the aerial parts of Angelica tenuissima inhibit lipid accumulation in vitro and in vivo. Planta Medica. 85(9-10):719-728