Publications

Xiao, M., C.H. Wu, G. Meek, B. Kelly, D.B. Castillo, L.E.A. Young, S. Martire, S. Dhungel, E. McCauley, P. Saha, A.L. Dube, M.S. Gentry, L.A. Banaszynski, R.C. Sun, and C.K. Kikani, PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence. Elife, 2023. 12. Full text

Kikani, CK ;Wu, X.;Fogarty, S ;Kang, SAW ;Dephoure, N ;Gygi, SP ;Sabatini, DM ;Rutter, J "Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program." Proceedings of the National Academy of Sciences of the United States of America 116, 21 (2019): 10382-10391. Details. Full text. Hide 

Kikani, CK ;Wu, X.;Paul, L ;Sabic, H ;Shen, Z ;Shakya, A ;Keefe, A ;Villanueva, C ;Kardon, G ;Graves, B ;Tantin, D ;Rutter, J "Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis." eLife 5, (2016): Details. Full text. Hide 

Wu, X.;Romero, D ;Swiatek, WI ;Dorweiler, I ;Kikani, CK ;Sabic, H ;Zweifel, BS ;McKearn, J ;Blitzer, JT ;Nickols, GA ;Rutter, J "PAS kinase drives lipogenesis through SREBP-1 maturation." Cell reports 8, 1 (2014): 242-55. Details. Full text. Hide 

Kikani, CK ;Verona, EV ;Ryu, J ;Shen, Y ;Ye, Q ;Zheng, L.;Qian, Z.;Sakaue, H ;Nakamura, K.;Du, J ;Ji, Q ;Ogawa, W ;Sun, LZ ;Dong, LQ ;Liu, F. "Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis." Science signaling 5, 249 (2012): ra80. Details. Full text. Hide 

Kikani, CK ;Antonysamy, SA ;Bonanno, JB ;Romero, R ;Zhang, FF ;Russell, M ;Gheyi, T ;Iizuka, M ;Emtage, S ;Sauder, JM ;Turk, BE ;Burley, SK ;Rutter, J "Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation." The Journal of biological chemistry 285, 52 (2010): 41034-43. Details. Full text. Hide 

Wang, C.;Xin, X ;Xiang, R ;Ramos, FJ ;Liu, M.;Lee, HJ ;Chen, H.;Mao, X.;Kikani, CK ;Liu, F.;Dong, LQ "Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells." The Journal of biological chemistry 284, 46 (2009): 31608-15. Details. Full text. Hide 

Wang, L.;Balas, B ;Christ-Roberts, CY ;Kim, RY ;Ramos, FJ ;Kikani, CK ;Li, C.;Deng, C ;Reyna, S ;Musi, N ;Dong, LQ ;DeFronzo, RA ;Liu, F. "Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo." Molecular and cellular biology 27, 18 (2007): 6497-505. Details. Full text. Hide 

Riojas, RA ;Kikani, CK ;Wang, C.;Mao, X.;Zhou, L ;Langlais, PR ;Hu, D ;Roberts, JL ;Dong, LQ ;Liu, F. "Fine tuning PDK1 activity by phosphorylation at Ser163." The Journal of biological chemistry 281, 31 (2006): 21588-93. Details. Full text. Hide 

Mao, X.;Kikani, CK ;Riojas, RA ;Langlais, P ;Wang, L.;Ramos, FJ ;Fang, Q ;Christ-Roberts, CY ;Hong, JY ;Kim, RY ;Liu, F.;Dong, LQ "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function." Nature cell biology 8, 5 (2006): 516-23. Details. Full text. Hide 

Kikani, CK ;Dong, LQ ;Liu, F. ""New"-clear functions of PDK1: beyond a master kinase in the cytosol?" Journal of cellular biochemistry 96, 6 (2005): 1157-62. Details. Full text. Hide 

Lim, MA ;Kikani, CK ;Wick, MJ ;Dong, LQ "Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function." Proceedings of the National Academy of Sciences of the United States of America 100, 24 (2003): 14006-11. Details. Full text. Hide