13. Efficient prime editing in vivo and in vitro using lipid nanoparticles

A.Y. Jiang*, A. Cristian*, D.L. Brooks, E.R. Feierman, P.Z. Chen, M.N. Whittaker, S.E. Pierce, H.A. Sakai, H. Chen, D. Liu, P.B. Randolph, A.H. Li, A. Hsu, S.O. Omo-Lamai, Y.A. Tao, B. Owusu-Amo, X. Wang, X. Wang, K. Musunuru, and D.R. Liu.

Nature Nanotechnology, In Press.

12. AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing

Y.A. Tao*, H.A. Sakai*, A.Y. Jiang*, N.A. Krasnow*, V.S. Vaganov, B. Shim, Z. Barsdale, N. Ahmed, M. Na, S. Pandey, A. Cristian, E. Zhang, J.A. Xu, M. Bulcaen, and D.R. Liu.

Nature Biotechnology, (2026)

11. Directed evolution of small RNA-stabilizing motifs that improve prime editing

H.A. Sakai*, S.E. Pierce*, A.Y. Jiang, A. Cristian, M. An, C.-R. Kim, N. Ahmed, C.F. Hemez, Y.A. Tao, E. Zhang, and D.R. Liu.

Nature Biotechnology, 1-11 (2026)

10. In vivo base editing rescues liver pathologies and peroxisome dysfunction in a mouse model of zellweger spectrum disorder

X.D. Gao*, M. Presa*, J.E. Duby, J. Ryan, P. Piec, A. Hsu, S. Banskota, A.Y. Jiang, L. Chen, G.A. Newby, E. Di Pietro, J.M. Levy, B.H. Steele, S. Lecordier, F. Qin, A.B. Moser, J. Xie, G. Gao, N.E. Braverman, A. Zuberi, J.G. Hacia, C.M. Lutz, and D.R. Liu.

Nature Biomedical Engineering, 1-20 (2026).

9. Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

J. Witten*, I. Raji*, R.S. Manan*, E. Beyer, S. Bartlett, Y. Tang, M. Ebadi, J. Lei, D. Nguyen, F. Oladimeji, A.Y. Jiang, E. MacDonald, Y. Hu, H. Mughal, A. Self, E. Collins, Z. Yan, J.F. Engelhardt, R. Langer, and D.G. Anderson.

Nature Biotechnology, 43: 1790-1799 (2024).

8. Zwitterionic polymer-functionalized lipid nanoparticles for the nebulized delivery of mRNA

A.Y. Jiang*, S. Lathwal*, S. Meng, J. Witten, E. Beyer, P. McMullen, Y. Hu, R. Manan, I. Raji, R. Langer, and D.G. Anderson.

Journal of the American Chemical Society, 146: 32567-32574 (2024).

7. Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry

B. Li*, I.O. Raji*, A. Gordon*, L. Sun, T. Raimondo, F. Oladimeji, A.Y. Jiang, A. Varley, R. Langer, and D.G. Anderson.

Nature Materials, 23: 1002-1008 (2024).

6. Combinatorial development of nebulized mRNA delivery formulations for the lungs

A.Y. Jiang*, J. Witten*, I.O. Raji*, F. Eweje, C. MacIsaac, S. Meng, F.A. Oladimeji, R. Langer, and D.G. Anderson.

Nature Nanotechnology, 19: 364-375 (2023).

5. Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA

B. Li*, A.Y. Jiang*, I. Raji*, C. Atyeo, T.R. Raimondo, A.G.R. Gordon, L.H. Rhym, T. Samad, C. MacIsaac, J. Witten, H. Mughal, T. Chicz, Y. Xu, R. McNamara, S. Bhatia, G. Alter, R. Langer, and D.G. Anderson.

Nature Biomedical Engineering, 9: 167-184 (2023).

4. A combinatorial library of biodegradable ionizable lipids enables efficient pulmonary delivery of mRNA and potent in vivo genome editing in lung epithelia

B. Li*, R. Manan*, S. Liang*, A.G.R. Gordon, A.Y. Jiang, A. Varley, G. Gao, R. Langer, W. Xue, and D.G. Anderson.

Nature Biotechnology, 41: 1410-1415 (2023).

3. Emerging immunomodulatory strategies for cell therapeutics

C.Y.X. Chua, A.Y. Jiang, T. Eufrasio-da-Silva, A. Dolatshahi-Pirouz, R. Langer, G. Orive, and A. Grattoni.

Trends in Biotechnology, 41: 358-373 (2023).

2. The clinical progress of mRNA vaccines and immunotherapies

A.J. Barbier, A.Y. Jiang, P. Zhang, R. Wooster, and D.G. Anderson.

Nature Biotechnology, 40: 840–854 (2022).

1. A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

B. Meksiriporn, M.B. Ludwicki, E.A. Stephens, A. Jiang, H.-C. Lee, D. Waraho-Zhmayev, L. Kummer, F. Brandl, A. Plückthun, and M.P. DeLisa.

Nature Communications, 10: 1830 (2019).