The Research Laboratory of Periodontal Tissue Engineering

Current Research Grants (as of 2019)

  • Synergism of Heme Oxygenase-1 Inducer and Bone Morphogenetic Protein-2 Inducer with a 3D-Printed Hydroxyapatite-Based Scaffold Promotes Alveolar Ridge Regeneration (PI) (Ministry of Science and Technology, Taiwan, 2019-2021)
  • Waveform Micro-Channel Guided Tooth-Tissue Interfacial Reconstruction (PI) (NTUH, Taiwan, 2018-2019)
  • Alveolar Ridge Regeneration Using A Biomimetic Scaffold with Degradable Viscoelastic Substrate (PI) (NHRI, Taiwan, 2019-2021)
  • Development of a Rapid-Prototyped Dual-Compartmental Scaffold for Periodontal Regeneration (PI) (National Taiwan University, Taiwan, 2019-2021)
  • Evaluation of Dental Implant Placement in the Sloped Alveolar Ridge (Co-PI) (NTUH, Taiwan, 2019)
  • Acceleration of Alveolar Ridge Regeneration Using A Rapidly Prototyped Three-Dimensional Calcium Phosphate-Based Scaffold (PI) (ITI, Switzerland, 2019-2020)
  • Development of a novel tissue engineering approach using adipose-derived stem cells to enhance skin and oral mucosa healing in diabetic subjects (Co-PI) (NTUH, Taiwan, 2020-2022)

Previous Research Grants

  • Design of A Hybrid Regeneration System Composed of Microspheres with Dual Biomolecules and Three-Dimensional Biomimetic Scaffold For Alveolar Ridge Augmentation (PI) (Ministry of Science and Technology, Taiwan, 2017-2019)
  • LED Light As An Adjunctive Treatment Modality of Periodontal Diseases (PI) (NTUH, Taiwan, 2017)
  • Promotion of Peri-implant Osteogenesis and Osseointegration by Functional Modification of Regenerative Membrane (PI) (Ministry of Science and Technology, Taiwan, 2016-2017)
  • Development of a Point-of-Care Periodontal Diagnostic Modality Based on the Cytokines in Saliva (PI) (NTUH, Taiwan, 2015-2016)
  • Termo-sensitive and pH-responsive nanogel encapsulating anti-glycation agents for periodontal treatment and bone regeneration (PI) (Ministry of Science and Technology, Taiwan, 2014-2016)
  • Modulatory mechanism of periodontopathogen-induced inflammation by using naringin (PI) (NTUH, Taiwan, 2014-2015)
  • A four-component design to combine anti-glycation and bioactive agents for periodontal regeneration (PI) (NHRI, Taiwan, 2014-2017)
  • Local Anti-Glycation Agent Delivery for the Periodontal Treatment (PI) (National Science Council, Taiwan, 2013-2014)
  • Aminoguanidine: A prospective medicine for periodontal treatment and promoting osseointegration (PI) (National University Health System, Singapore, 2011-2012)
  • Advanced glycated end-products in periodontal destruction (PI) (NUS, Singapore, 2011-2012)
  • Mathematical modeling of the esthetic anterior crown-mucogingival profile (PI) (NUS, Singapore 2011-2012)
  • Dual compartmental growth factor delivery to achieve periodontal tissue regeneration (PI) (National Medical Research Council, Singapore, 2010-2012)
  • Synergetic biomolecules delivery to promote diabetic dentoalveolar regeneration (PI) (NUS, Singapore, 2010-2012)

Waveform micro-channel scaffold for periodontal ligament regeneration (NTUH 2018-2019; NTU 2019-2021)

A. The tooth structure. Periodontal ligament is located between the root surface and alveolar bone.B. Waveform micro-channels were designed for guiding the growth of periodontal ligament fibers.C. The waveform micro-channels on the fluid flow chamber of the bioreactor.D. The micro-channels were made by collagen using a bioprinter and were compatible with periodontal ligament fibroblasts.

Rapid-prototyped biomimetic scaffold with biodegradable substrate (NHRI 2019-2021; ITI 2019-2020)

A. The diagrams of rapidly prototyped biomimetic scaffold, viscoelastic artificial substrate loaded with stem cells, and the applications of scaffold+substrate for promoting supra-alveolar ridge augmentation. B. Examples of a biomimetic scaffold fabricated by a bioprinter, an alginate-based substrate, and a harvested scaffold-substrate treated specimen.

Multiphasic scaffold for periodontal regeneration (NHRI 2014-2017; MOST 2014-2016; MOST 2016-2017)

The scaffold (upper panel) was composed of a biphasic (lower panel, left) periodontal ligament (by gelatin)-bone (by gelatin-hydroxyapatite) component, a barrier (lower panel, middle) component with PDGF-metronidazole encapsulated nanofibers, and a inflammation-responsive (lower panel, right) hydrogel which was rapidly gelated in body temperature and allowed burst release of carried medicine in the acidic environment.