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LAB FOCUS
Our lab focuses on the circuitry mechanism of motor control and cognitive function from the cerebellar perspective. We specifically focus on mechanisms with:
1) Formula-level precision: precise mechanisms that are numerically precise and describable by equations.
2) Cross-individual uniformity: foundational mechanisms that can be applied to everyone uniformly without the need of individual calibration.
3) Engineerability: direct mechanisms that are beyond qualitative causality, but allowed quantitative tuning, achieving behavioral engineering.
As a lab of MD background, we also apply translational approaches to investigate the pathophysiology of movement disorders, such as Parkinson's disease, tremor and ataxia.
An engineerable neural equations for motor frequency control
Motor (frequency, time) = Cerebellum (frequency, time)
An engineerable neural equations for reward computation with single-trial precision
IPS (size, time) ∝ Reward-prediction error (size, time)
APPROACHES
Animal
Complex behavioral tracking
Fiber Photometry
In vivo electrophysiology
In vivo multi-photon imaging
Optogenetics
Tissue clearing
Human
Clinical Electrophysiology
MRI
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