The College of Science and Mathematics (CSM) - Natural Science Museum is a unit under the Office of the Dean of the CSM. It is headed by a Museum-in-charge who is tasked to maintain all the collected specimens, properly mounted, classified, and arranged to a generally accepted system of classification and systematic order of Philippine Flora and Fauna for both terrestrial and the aquatic.

The museum is also a vital center for scientific research, especially for taxonomic research of the country's flora and fauna. It also serves as a major repository of resources for research, conservation, and education.

The Museum has two display facilities and reference collections. The Terrestrial display area is located at the CSM Rooftop. The collections on display include the Majestic Philippine Eagle and a number of Ornithological, Mammalian, Entomological, and Herpetological species. The Marine and Botanical Collection is on the CSM rooftop (Annex) and houses a wide variety of marine and botanical specimens.