Biophysical Chemistry Laboratory

Publications

Research Articles (251)

P. Kumar, T. Vaillant, M. Kianinia, H. Wen, A. Stewart, P. J. Reece, H. A. Girard, J.-C. Arnault, H.-C. Chang, I. Aharonovich, and S. L. Y. Chang*, “Disordered carbon shells enable shape dependent fluorescence enhancement in nanodiamond quantum sensors revealed by correlative TEM-fluorescence microscopy,” Adv. Funct. Mater. (2026) under revision.
T.-N. Le, X. M. Lam, Y.-X. Tang, Y. Y. Hui, A.-J. Liu, and H.-C. Chang*, “Quantum spin detection in microfiltration immunoassays for ultrasensitive and high-throughput diagnostics,” Anal. Chem. (2026) DOI: 10.1021/acs.analchem.5c05569.
Y. Y. Hui*, Y.-M. Tsui, Y.-X. Tang, and H.-C. Chang*, “Ultrathin fluorescent nanodiamond films for nanoscale quantum sensing in operando semiconductor devices,” Adv. Funct. Mater. 36, e13406 (2026).
N. Lu*, G. Gurumallappa, P. Y. Liu, K. L. Chan, Y.-C. Huang, Y.-C. Lin, Y.-T. Hsieh, P.-X. Zeng, Y. Gowda, M.-H. Tsai, E. Tessema, H.-C. Chang, and J. Francisco*, “Neutron diffraction and spectroscopic studies of intramolecular tetrel bonds in three fluorinated zinc complexes: Significant redshift in the sp3 C−H stretch confirmed by experiments and theory,” J. Am. Chem. Soc. 147, 45270–45282 (2025).
Y.-X. Tang, Y. Y. Hui, A.-J. Liu, W. W.-W. Hsiao, and H.-C. Chang*, “Quantitative laser-scanning lateral flow immunoassay of luteinizing hormone with a handheld analyzer,” J. Chin. Chem. Soc. 72, 693–701 (2025).
T.-I. Yang, Y. Y. Hui, P.-J. Wu, T.-P. Huang, B.-M. Cheng, Y.-Y. Lee, and H.-C. Chang*, “Light yields of diamonds with nitrogen-vacancy centers as scintillators for ionizing radiations from 80 to 1200 eV,” J. Phys. Chem. C 129, 2739–2746 (2025).
Y. Y. Hui, C.-Y. Ho, T.-I. Yang, T.-P. Huang, B.-M. Cheng, Y.-Y. Lee, and H.-C. Chang*, “Fluorescent nanodiamond scintillators for beam diagnostics of EUV and soft X-ray in photolithographic applications,” RSC Adv. 15, 1011–1019 (2025).
S. C. Wang, P.-Y. Lin, J.-C. Yang, J. L. Gutmann, H.-C. Chang H.-M. Huang*, and S.-C. Hsieh*, “Micro-CT evaluation of a nanodiamond irrigant for hard-tissue debris removal during sonic agitation,” Int. Endo. J. 58, 346–356 (2025).
G. Gurumallappa, C.-F. Chiu, C.-L. Ho, H.-C. Chang, H. M. Krishnegowda, N. K. Lokanath, and N. Lu*, “Synthesis, structure and non-covalent interactions of trans-[2-(HCF2(CF2)3CH2OCH2)2-py-PdCl2] complex: rare C−F⋯F−C halogen bonds and blue-shifting C−H⋯X hydrogen bonds,” J. Mol. Struct. 1322, 140303 (2025) (12pp).
D. Duan, V. K. Kavatamane, S. R. Arumugam, H.-C. Chang, and G. Balasubramanian*, “Nitrogen-vacancy centers as a self-gauged micro-scale heater and its application for multi-modal sensing,” App,. Phys. Lett. 125, 132202 (2024) (6pp).
W. W.-W. Hsiao*, S. Angela, T.-N. Le, G. Fadhilah, W.-H. Chiang, and H.-C. Chang, “Diagnostics of Alzheimer's disease using fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay,” Microchem. J. 205, 111315 (2024) (9pp).
S.-Y. Liang, M. I. C. Estayan, L.-W. Hsieh, M.-C. Pan, K. X. Li, H.-C. Chang, and W.-P. Peng*, “Real-time monitoring of the evaporation and fission of electrospray-ionized polystyrene beads and bacterial pellets at elevated temperatures,” Anal. Chem. 96, 7179–7186 (2024).
T.-N. Le, M. J. N. Descanzo, W. W.-W. Hsiao, P.-C. Soo, W.-P. Peng, and H.-C. Chang*, “Fluorescent nanodiamond immunosensors for clinical diagnostics of tuberculosis,” J. Mater. Chem. B 12, 3533–3542 (2024).
H.-Y. Wu*, G. Kabacaoğlu, E. Nazockdast, H.-C. Chang, M. J. Shelley, and D. J. Needleman, “Laser ablation and fluid flows reveal the mechanism behind spindle and centrosome positioning,” Nat. Phys. 20, 157–168 (2024).
N. Varkentina, Y. Auad, S. Y. Woo, F. Castioni, J.-D. Blazit, M. Tencé, H.-C. Chang, J. Chen, K. Watanabe, T. Taniguchi, M. Kociak, and L. H. G. Tizei*, “Excitation lifetime extracted from electron–photon (EELS-CL) nanosecond-scale temporal coincidences,”Appl. Phys. Lett. 123, 223502 (2023) (6pp).
T.-I. Yang, Y.Y. Hui, J.-I. Lo, Y.-W. Huang, Y.-Y. Lee, B.-M. Cheng*, and H.-C. Chang*, “Imaging extreme ultraviolet radiation using nanodiamonds with nitrogen-vacancy centers,” Nano Lett. 23, 9811–9816 (2023).
H.-H. Lin, C.-Y. Wang, F.-J. Hsieh, F.-Z. Liao, Y.-K. Su, M. D. Pham, C.-Y. Lee, H.-C. Chang*, and H.-H. Hsu*, “Nanodiamonds in oil emulsions elicit potent immune responses for effective vaccination and therapeutics,” Nanomedicine 18, 1045–1059 (2023).
H. Wen, D. Kordahl, I. Kuschnerous, P. Reineck, A. Macmillan, H.-C. Chang, C. Dwyer, and S. L. Y. Chang*, “Correlative fluorescence and transmission electron microscopy assisted by 3D machine learning reveals thin nanodiamonds fluoresce brighter,” ACS Nano 17, 16491–16500 (2023).
T.-N. Le, H.-Y. Chen, X. M. Lam, C.-C. Wang, and H.-C. Chang*, “Antibody-conjugated nanodiamonds Imaging extreme ultraviolet radiation using fluorescent nanodiamonds with nitrogen-vacancy centersas dual-functional immunosensors for in vitro diagnostics,” Anal. Chem. 95, 12080–12088 (2023).
C.-S. Huang, C.-H. Hsiao, Y.-C. Chang, C.-H. Chang, J.-C. Yang, J. L. Gutmann, H.‐C. Chang, H.-M. Huang*, and S.-C. Hsieh*, “A novel endodontic approach in removing smear layer using nano and submicron diamonds with intracanal oscillation irrigation,” Nanomaterials 13, 1646 (2023) (16pp).
V. Elakkat, E. Tessema, C.-H. Lin, X. Wang*, H.-C. Chang, Y.-N. Zheng, Y.-C. Huang, G. Gurumallappa, Z.-Y. Zhang, K. L. Chan, H. A. Rahayu, J. S. Francisco, and N. Lu*, “Unusual changes of C–H bond lengths in chiral zinc complexes induced by noncovalent interactions,” Angew. Chem. Int. Ed. 62, e202215438 (2023) (8pp).
T.-I. Yang, T. Azuma, Y.-W. Huang, Y.-Y. Hui, C.-T. Chiang, and H.-C. Chang*, “Stimulated emission cross sections and temperature-dependent spectral shifts of neutral nitrogen-vacancy centers in diamonds,” J. Chin. Chem. Soc. 70, 451–459 (2023).
T.-N. Le, W. W.-W. Hsiao*, Y.-Y. Cheng, C.-C. Lee, T.-T. Huynh, M. D. Pham, M. Chen, M.-W. Jen, H.-C. Chang*, and W.-H. Chiang*, “Spin-enhanced lateral flow immunoassay for high-sensitivity detection of nonstructural protein NS1 serotypes of dengue virus,” Anal. Chem. 94, 17819–17826 (2022).
T.-I. Yang, Y.-W. Huang, P. Bista, C.-F. Ding, J. Chen, Y.-H. Chan, C.-T. Chiang*, and H.-C. Chang*, “Photoluminescence of nitrogen-vacancy centers by ultraviolet one- and two-photon excitation of fluorescent nanodiamonds,” J. Phys. Chem. Lett. 13, 11280–11287 (2022).
W. W.-W. Hsiao*, N. Sharma, T.-N. Le, Y.-Y. Cheng, C.-C. Lee, D.-T. Vo, Y.-Y. Hui, H.-C. Chang, and W.-H. Chiang*, “Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variants,” Anal. Chim. Acta 1230, 340389 (2022) (8pp).
Y. Y. Hui, Y.-X. Tang, T. Azuma, H.-H. Lin, F.-Z. Liao, Q.-Y. Chen, J.-H. Kuo, Y.-L. Wang, and H.-C. Chang*, “Design and implementation of a low-cost portable reader for thermometric lateral flow immunoassay,” J. Chin. Chem. Soc. 69, 1356–1365 (2022).
T. Azuma, Y. Y. Hui, O. Y. Chen, Y.-L. Wang, and H.-C. Chang*, “Thermometric lateral flow immunoassay with colored latex beads as reporters for COVID-19 testing,” Sci. Rep. 12, 3905 (2022) (12pp).
A. A. Patil, M. J. N. Descanzo, J. B. A. Agcaoili, C.-K. Chiang, C.-L. Cheng, H.-C. Chang, and W.-P. Peng*, “Carboxylated/oxidized diamond nanoparticles for quantifying immunoglobulin G antibodies using mass spectrometry,” ACS Appl. Nano Mater. 4, 8922–8936 (2021).
S. Meuret*, L. H.G. Tizei, F. Houdellier, Y. Auad, S. Weber, H.-C. Chang, M. Kociak and A. Arbouet*, “Time-resolved cathodoluminescence in an ultrafast transmission electron microscope,” Appl. Phys. Lett. 119, 062106 (2021) (6pp).
J. Chen*, O. Y. Chen*, and H.-C. Chang*, “Relaxation of a dense ensemble of spins in diamond under a continuous microwave driving field,” Sci. Rep. 11, 16278 (2021) (12pp).
T. T. Ho, V. T. Pham, T. T. Nguyen, T. V. Bao, V. T. Trinh, Q. M. Dang, H.-H. Lin, H. T. Bui, P. T. M. Nguyen, N. B. Pham, T. B. L. Thi, C. V. Phan, H.-C. Chang, W. W.-W. Hsiao, H. H. Chu*, and M. D. Pham*, “Effects of size and surface properties of nanodiamonds on the immunogenicity of recombinant H5 protein of A/H5N1 virus in mice,” Nanomaterials 11, 1597 (2021) (15pp).
Y. Y. Hui, O. Y. Chen, H.-H. Lin, Y.-K. Su, K. Chen, C.-Y. Wang, W. W.-W. Hsiao, and H.-C. Chang*, “Magnetically modulated fluorescence of nitrogen-vacancy centers in nanodiamonds for ultrasensitive biomedical analysis,” Anal. Chem. 93, 7140–7147 (2021).
N. Prabhakar*, I. Belevich, M. Peurla, X. Heiligenstein, H.-C. Chang, C. Sahlgren, E. Jokitalo, and J. M. Rosenholm, “Cell volume (3D) correlative microscopy facilitated by intracellular fluorescent nanodiamonds as multi-modal probes,” Nanomaterials 11, 14 (2021) (10pp).
S. Meuret, Y. Auad, L. Tizei, H.-C. Chang, F. Houdellier, M. Kociak, and A. Arbouet, “Time-resolved cathodoluminescence in a transmission electron microscope applied to NV centers in diamond,” Microsc. Microanal. 26 (S2), 2022-2023 (2020).
D. Duan, V. K. Kavatamane, S. R. Arumugam, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Tapered ultra-high NA optical fiber tip for nitrogen-vacancy ensembles based endoscope in a fluidic environment,” Appl. Phys. Lett. 116, 113701 (2020) (6pp).
H.-C. Lu*, J.-I. Lo, Y.-C. Peng, S.-L. Chou, B.-M. Cheng*, and H.-C. Chang*, “Nitrogen-vacancy centers in diamond for high-performance detection of vacuum ultraviolet, extreme ultraviolet and X-rays,” ACS Appl. Mater. Interfaces 12, 3847−3853 (2020).
S.-J. Kuo, S.-W. Chang, Y. Y. Hui, O. Y. Chen, Y.-W. Chen, C.-C. Lin, D. Wan, H.-L. Chen*, and H.-C. Chang*, “Fluorescent microdiamonds conjugated with hollow gold nanoparticles as photothermal fiducial markers in tissue,” J. Mater. Chem. C 7, 15197−15207 (2019).
B.-M. Chang, L. Pan, H.-H. Lin, and H.-C. Chang*, “Nanodiamond-supported silver nanoparticles as potent and safe antibacterial agents,” Sci. Rep. 9, 13164 (2019) (11pp).
Y. Xu, Y. Su, Y. Yu, Y. Y. Hui, J. Cheng, H.-C. Chang, Y. Zhang, Y. R. Shen, and C. Tian*, “Mapping dynamical magnetic responses of ultra-thin superconducting films using nitrogen-vacancy centers in diamond,” Nano Lett. 19, 5697−5702 (2019).
L.-J. Su, H.-H. Lin, M.-H. Wu, L. Pan, K. Yadav, H.-H. Hsu, T.-Y. Ling, Y.-T. Chen, and H.-C. Chang*, “Intracellular delivery of luciferase with fluorescent nanodiamonds for dual-modality imaging of human stem cells,” Bioconjugate Chem. 30, 2228−2237 (2019).
Y. Y. Hui, O. Y. Chen, T. Azuma, B.-M. Chang, F.-J. Hsieh, and H.-C. Chang*, “All-optical thermometry with nitrogen-vacancy centers in nanodiamond-embedded polymer films,” J. Phys. Chem. C 123, 15366−15374 (2019).
F.-J. Hsieh, S. Sotoma, H.-H. Lin, C.-Y. Cheng, T.-Y. Yu, C.-L. Hsieh, C.-H. Lin*, and H.-C. Chang*, “Bioorthogonal fluorescent nanodiamonds for continuous long-term imaging and tracking of membrane proteins,” ACS Appl. Mater. Interfaces 11, 19774–19781 (2019).
D. Duan, V. K. Kavatamane, S. R. Arumugam, G. Rahane, G. Du, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Laser induced heating in a high-density ensemble of nitrogen-vacancy centers in diamond and its effects on quantum sensing,” Opt. Lett. 44, 2851–2854 (2019).
F.-J. Hsieh, Y.-W. Chen, Y. Y. Hui, C.-H. Lin, and H.-C. Chang*, “Quantification and imaging of antigens on cell surface with lipid-encapsulated fluorescent nanodiamonds,” Micromachines 10, 304 (2019) (10pp).
D. Duan, G. Du, V. K. Kavatamane, G. Rahane, S. R. Arumugam, Y.-K. Tzeng, H.-C. Chang, and G. Balasubramanian*, “Efficient nitrogen-vacancy centers' fluorescence excitation and collection from micrometer-sized diamond by a tapered optical fiber in endoscope-type configuration,” Opt. Express 27, 6734–6745 (2019).
S.-Y. Liang, A. A. Patil, C.-H. Han, S.-W. Chou, W. Chang, P.-C. Soo, H.-C. Chang, and W.-P. Peng*, “Ionization of submicron-sized particles by laser-induced RF plasma for mass spectrometric analysis,” Anal. Chem. 90, 13236–13242 (2018).
S.-J. Kuo, P.-C. Tsai, Y.-C. Lee, S.-W. Chang, S. Sotoma, C.-Y. Fang, H.-C. Chang, and H.-L. Chen*, “Manipulating the distribution of electric field intensity to effectively enhance the spatial and spectral fluorescence intensity of fluorescent nanodiamonds,” Nanoscale 10, 17576–17584 (2018).
S. Sotoma*, F.-J. Hsieh, and H.-C. Chang*, “Single-step metal-free grafting of cationic polymer brushes on fluorescent nanodiamonds,” Materials 11, 1479 (2018) (9pp).
Duan, V. K. Kavatamane, S. R. Arumugam, G. Rahane, Y.-K. Tzeng, H.-C. Chang, H. Sumiya, S. Onoda, J. Isoya, and G. Balasubramanian*, “Enhancing fluorescence excitation and collection from the nitrogen-vacancy center in diamond through a micro-concave mirror,” Appl. Phys. Lett. 113, 041107 (2018) (5pp).
P. R. Dolan, S. Adekanye, A. A. P. Trichet, S. Johnson, L. Flatten, Y. C. Chen, L. Weng, D. Hunger, H.-C. Chang, S. Castelletto, and J. M. Smith*, “Robust, tunable, and high purity triggered single photon source at room temperature using a nitrogen-vacancy defect in diamond in an open microcavity,” Opt. Express 26, 7056–7065 (2018).
J. Zhao, Y. Cheng, H. Shen, Y. Y. Hui, T. Wen, H.-C. Chang, Q. Gong, and G. Lu*, “Light emission from plasmonic nanostructures enhanced with fluorescent nanodiamonds,” Sci. Rep. 8, 3605 (2018) (8pp).
H. Lourenco-Martins, M. Kociak, S. Meuret, F. Treussart, Y. H. Lee, X. Y. Ling, H.-C. Chang, and L. H. G. Tizei*, “Probing plasmon-NV0 coupling at the nanometer scale with photons and fast electrons,” ACS Photonics 5, 324–328 (2018).
S. Sotoma*, F.-J. Hsieh, Y.-W. Chen, P.-C. Tsai, and H.-C. Chang*, “Highly stable lipid-encapsulation of fluorescent nanodiamonds for bioimaging applications,” Chem. Commun. 54, 1000–1003 (2018).
F.-J. Hsieh, Y.-W. Chen, Y.-K. Huang, H.-M. Lee, C.-H. Lin, and H.-C. Chang*, “Correlative light-electron microscopy of lipid-encapsulated fluorescent nanodiamonds for nanometric localization of cell surface antigens,” Anal. Chem. 90, 1566–1571 (2018).
N. Prabhakar, M. Peurla, S. Koho, T. Deguchi, T. Näreoja, H.-C. Chang, J. M. Rosenholm*, and P. E. Hänninen, “STED-TEM correlative microscopy leveraging nanodiamonds as intracellular dual-contrast markers,” Small 14, 1701807 (2018) (7pp).
H.-C. Lu*, Y.-C. Peng, S.-L. Chou, J.-I. Lo, B.-M. Cheng*, and H.-C. Chang*, “Far-UV excited luminescence of nitrogen-vacancy centers: Evidence for diamonds in space,” Angew. Chem. Int. Ed. 56, 14469–14473 (2017).
N. B. Pham, T. T. Ho, G. T. Nguyen, T. T. Le, N. T. Le, H.-C. Chang, M. D. Pham, U. Conrad, and H. H. Chu*, “Nanodiamond enhances immune responses in mice against recombinant HA/H7N9 protein,” J. Nanobiotechnol. 15, 69 (2017) (12pp).
V. I. Korepanov, H. Hamaguchi*, E. Osawa, V. Ermolenkov, I. Lednev, B. J. M. Etzold, O. Levinson, B. Zousman, C. P. Epperla, and H.-C. Chang, “Carbon structure in nanodiamonds elucidated from Raman spectroscopy,” Carbon 121, 322–329 (2017).
Y.-W. Chen, C.-H. Lee, Y.-L. Wang, T.-L. Li, and H.-C. Chang*, “Nanodiamonds as nucleating agents for protein crystallization,” Langmuir 33, 6521–6527 (2017).
N. Prabhakar, M. H. Khan, M. Peurla, H.-C. Chang, P. E. Hänninen, and J. M. Rosenholm*, “Intracellular trafficking of fluorescent nanodiamonds and regulation of their cellular toxicity,” ACS Omega 2, 2689–2693 (2017).
M. D. Pham, C. P. Epperla, C.-L. Hsieh, W. Chang, and H.-C. Chang*, “Glycosaminoglycans-specific cell targeting and imaging using fluorescent nanodiamonds coated with viral envelope proteins,” Anal. Chem. 89, 6527–6534 (2017).
S. Haziza*, N. Mohan, Y. Loe-Mie, A.-M. Lepagnol-Bestel, S. Massou, M.-P. Adam, X. L. Le, J. Viard, C. Plancon, R. Daudin, P. Koebel, E. Dorard, C. Rose, F.-J. Hsieh, C.-C. Wu, B. Potier, Y. Herault, C. Sala, A. Corvin, B. Allinquant, H.-C. Chang, F. Treussart*, and M. Simonneau*, "Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain disease-related genetic risk factors,” Nat. Nanotechnol. 12, 322–328 (2017).
L.-J. Su, M.-H. Wu, Y. Y. Hui, B.-M. Chang, L. Pan, P.-C. Hsu, Y.-T. Chen, H.-N. Ho, Y.-H. Huang, T.-Y. Ling*, H.-H. Hsu*, and H.-C. Chang*, “Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs,” Sci. Rep. 7, 45607 (2017) (11pp).
P.-C. Tsai, C. P. Epperla, J.-S. Huang, O. Y. Chen, C.-C. Wu, and H.-C. Chang*, “Measuring nanoscale thermostability of cell membranes with single gold-diamond nanohybrids,” Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
K.-K. Liu, W.-R. Qiu, E. N. Raj, H.-F. Liu, H.-S. Huang, Y.-W. Lin, C.-J. Chang, T.-H. Chen, C. Chen, H.-C. Chang, J.-K. Hwang, and J.-I. Chao*, “Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway,” Autophagy 13, 187–200 (2017).
C. Xiong, X. Zhou, Q. He, X. Huang, J. Wang, W.-P. Peng, H.-C. Chang, and Z. Nie*, “The development of visible-wavelength MALDI cell mass spectrometry (CMS) for high-efficiency single-cell analysis,” Anal. Chem. 88, 11913–11918 (2016).
H. Kaupp, T. Hümmer, B. Schlederer, H.-C. Chang, H. Fedder, R. Reuter, T. W. Hänsch, and D. Hunger*, “Purcell-enhanced single-photon emission from nitrogen-vacancy centers coupled to a tunable microcavity,” Phys. Rev. Appl. 6, 054010 (2016).
C. H. Nee, S. L. Yap, T. Y. Tou, H.-C. Chang, and S. S. Yap*, “Direct synthesis of nanodiamonds by femtosecond laser irradiation of ethanol,” Sci. Rep. 6, 33966 (2016) (8pp).
H. Shen, R. Y. Chou, Y. Y. Hui, Y. He, Y. Cheng, H.-C. Chang, L. Tong, Q. Gong, and G. Lu*, “Directional fluorescence emission from a compact plasmonic-diamond hybrid nanostructure,” Laser Photon. Rev. 10, 647–655 (2016).
N. Zhang, K. Zhu, C. Xiong, Y. Jiang, H.-C. Chang, and Z. Nie*, “Mass measurement of single intact nanoparticles in a cylindrical ion trap,” Anal. Chem. 88, 5958–5962 (2016).
S. Nagarajan, C. Pioche-Durieu, L. H. G. Tizei, C.-Y. Fang, J.-R. Bertrand, E. Le Cam, H.-C. Chang, F. Treussart*, and M. Kociak*, “Simultaneous cathodoluminescence and electron microscopy cytometry of cellular vesicles labeled with fluorescent nanodiamonds,” Nanoscale 8, 11588–11594 (2016).
M. D. Pham, T.-C. Wen, H.-C. Li, P.-H. Hsieh, Y.-R. Chen, H.-C. Chang*, and C.-C. Han*, “Streamlined membrane proteome preparation for shotgun proteomics analysis with Triton X-100 cloud point extraction and nanodiamond solid phase extraction,” Materials 9, 385 (2016) (17pp).
M. K. Pola, M. V. R. Raju, C.-M. Lin, R. Putikam, M.-C. Lin, C. P. Epperla, H.-C. Chang, S.-Y. Chen, and H.-C. Lin*, “A fully-aqueous red-fluorescent probe for selective optical sensing of Hg2+ and its application in living cells,” Dyes Pigments 130, 256–265 (2016).
C. P. Epperla, O. Y. Chen, and H.-C. Chang*, “Gold/diamond nanohybrids may reveal how hyperlocalized hyperthermia kills cancer cells,” Nanomedicine 11, 443–445 (2016).
B. Yang, C.-Y. Fang, H.-C. Chang, F. Treussart, J.-B. Trebbia, and B. Lounis*, “Polarization effects in lattice-STED microscopy,” Faraday Discuss. 184, 37–49 (2015).
C. P. Epperla, N. Mohan, C.-W. Chang, C.-C. Chen, and H.-C. Chang*, “Nanodiamond-mediated intercellular transport of proteins through membrane tunneling nanotubes,” Small 11, 6097–6105 (2015).
K.-H. Chen, D. J. Lundy, E. K. W. Toh, C.-H. Chen, C. Shih, P. Chen, H.-C. Chang, J. J. Lai, P. S. Stayton, A. S. Hoffman, and P. C. H. Hsieh*, “Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific,” Nanoscale 7, 15863–15872 (2015).
H.-H. Lin, H.-W. Lee, R.-J. Lin, C.-W. Huang, Y.-C. Liao, J.-M. Fang, Y.-T. Chen, T.-C. Lee, A. L. Yu*, and H.-C. Chang*, “Tracking and finding slow-proliferating/quiescent cancer stem cells with fluorescent nanodiamonds,” Small 11, 4394–4402 (2015).
P.-C. Tsai, O. Y. Chen, Y.-K. Tzeng, Y. Y. Hui, J. Y. Guo, C.-C. Wu, M.-S. Chang*, and H.-C. Chang*, “Gold/diamond nanohybrids for quantum sensing applications,” EPJ Quantum Technol. 2, 19 (2015) (12pp).
C.-L. Lin, C.-H. Lin, H.-C. Chang*, and M.-C. Su*, “Protein attachment on nanodiamonds,” J. Phys. Chem. A 119, 7704–7711 (2015).
Z. Chu, K. Miu, P. Lung, S. Zhang, S. Zhao, H.-C. Chang, G. Lin, and Q. Li*, “Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery,” Sci. Rep. 5, 11661 (2015) (8pp).
Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
T. Plakhotnik*, H. Aman, and H.-C. Chang, “All-optical single-nanoparticle ratiometric thermometry with a noise floor of 0.3 K•Hz–1/2,” Nanotechnology 26, 245501 (2015) (7pp).
R. Silbajoris, W. Linak, O. Shenderova, C. Winterrowd, H.-C. Chang, J. L. Zweier, A. Kota, L. A. Dailey, P. A. Bromberg, and J. M. Samet*, “Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation,” Diamond Relat. Mater. 58, 16–23 (2015).
S. Meuret, L. H. G. Tizei, T. Cazimajou, R. Bourrellier, H.-C. Chang, F. Treussart, and M. Kociak*, “Photon bunching in cathodoluminescence,” Phys. Rev. Lett. 114, 197401 (2015) (5pp).
T. Zhang, H. Cui, C.-Y. Fang, K. Cheng, X. Yang, H.-C. Chang, and M. L. Forrest*, “Targeted nanodiamonds as phenotype-specific photoacoustic contrast agents for breast cancer,” Nanomedicine 10, 573–587 (2015).
A. Singh, R. Singh, M. Shellaiah, E. C. Prakash, H.-C. Chang, P. Raghunath, M.-C. Lin, and H.-C. Lin*, “A new pyrene-based aggregation induced ratiometric emission probe for selective detections of trivalent metal ions and its living cell application,” Sensor. Actuat. B-Chem. 207, 338–345 (2015).
C.-Y. Fang, C.-C. Chang, C.-Y. Mou, and H.-C. Chang*, “Preparation and characterization of ion-irradiated nanodiamonds as photoacoustic contrast agents,” J. Nanosci. Nanotech. 15, 1037−1044 (2015).
Y.-A. Huang, C.-W. Kao, K.-K. Liu, H.-S. Huang, M.-H. Chiang, C.-R. Soo, H.-C. Chang, T.-W. Chiu*, J.-I. Chao*, and E. Hwang*, “The effect of fluorescent nanodiamonds on neuronal survival and morphogenesis,” Sci. Rep. 4, 6919 (2014) (10pp).
M. Kayci, H.-C. Chang, and A. Radenovic*, “Electron spin resonance of nitrogen-vacancy defects embedded in single nanodiamonds in an ABEL trap,” Nano Lett. 14, 5335–5341 (2014).
Y. Y. Hui, L.-J. Su, O. Y. Chen, Y.-T. Chen, T.-M. Liu, and H.-C. Chang*, “Wide-field imaging and flow cytometric analysis of cancer cells in blood by fluorescent nanodiamond labeling and time gating,” Sci. Rep. 4, 5574 (2014) (7pp).
T.-R. Kuo, W.-Y. Lai, C.-H. Li, Y.-Z. Wen, H.-C. Chang, J.-S. Chen, P.-C. Yang, and C.-C. Chen*, “AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging,” Nano Res. 7, 658–669 (2014).
T.-C. Hsu, K.-K. Liu, H.-C. Chang, E. Hwang, and J.-I. Chao*, “Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds,” Sci. Rep. 4, 5004 (2014) (11pp).
C. Xiong, X. Zhou, N. Zhang, L. Zhan, S. Chen, W.-P. Peng, H.-C. Chang, and Z. Nie*, “Quantitative assessment of protein adsorption on microparticles with particle mass spectrometry,” Anal. Chem. 86, 3876–3881 (2014).
Z. Chu, S. Zhang, B. Zhang, C. Zhang, C.-Y. Fang, I. Rehor, P. Cigler, H.-C. Chang, G. Lin, R. Liu, and Q. Li*, “Unambiguous observation of shape effects on cellular fate of nanoparticles,” Sci. Rep. 4, 4495 (2014) (9pp).
Y. Nawa, W. Inami, S. Lin, Y. Kawata*, S. Terakawa, C.-Y. Fang, and H.-C. Chang, “Multi-color imaging of fluorescent nanodiamonds in living HeLa cells using direct electron-beam excitation,” ChemPhysChem 15, 721–726 (2014).
X. Yang, Y.-K. Tzeng, Z. Zhu, Z. Huang, X. Chen, Y. Liu, H.-C. Chang, L. Huang*, W.-D. Li*, and P. Xi*, “Sub-diffraction imaging of nitrogen-vacancy centers in diamond by stimulated emission depletion and structured illumination,” RSC Adv. 4, 11305–11310 (2014).
M. V. R. Raju, E. C. Prakash, H.-C. Chang, and H.-C. Lin*, “A facile ratiometric fluorescent chemodosimeter for hydrazine based on Ing-Manske hydrazinolysis and its applications in living cells,” Dyes Pigments 103, 9–20 (2014).
T.-R. Kuo, D.-Y. Wang, Y.-C. Chiu, Y.-C. Yeh, W.-T. Chen, C.-H. Chen, C.-W. Chen, H.-C. Chang, C.-C. Hu, and C.-C. Chen*, “Layer-by-layer thin film of reduced graphene oxide and gold nanoparticles as an effective sample plate in laser-induced desorption/ionization mass spectrometry,” Anal. Chim. Acta 809, 97–103 (2014).
L. H. G. Tizei, S. Meuret, S. Nagarajan, F. Treussart, C.-Y. Fang, H.-C. Chang, and M. Kociak*, “Spatially and spectrally resolved cathodoluminescence with fast electrons: A tool for background subtraction in luminescence intensity second-order correlation measurements applied to subwavelength inhomogeneous diamond nanocrystals,” Phys. Status Solidi A 210, 2060–2065 (2013).
H. Kaupp, C. Deutsch, H.-C. Chang, J. Reichel, T. W. Hänsch, and D. Hunger*, “Scaling laws of the cavity enhancement for nitrogen-vacancy centers in diamond,” Phys. Rev. A 88, 053812 (2013) (8pp).
B.-M. Chang, H.-H. Lin, L.-J. Su, W.-D. Lin, R.-J. Lin, Y.-K. Tzeng, R. T. Lee, Y. C. Lee, A. L. Yu*, and H.-C. Chang*, “Highly fluorescent nanodiamonds protein-functionalized for cell labeling and targeting,” Adv. Funct. Mater. 23, 5737–5745 (2013).
H.-C. Li, F.-J. Hsieh, C.-P. Chen, M.-Y. Chang, P. C. H. Hsieh, C.-C. Chen, S.-U. Hung, C.-C. Wu, and H.-C. Chang*, “The hemocompatibility of oxidized diamond nanocrystals for biomedical applications," Sci. Rep. 3, 3044 (2013) (8pp).
T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nat. Nanotechnol. 8, 682–689 (2013).
Y. Kuo, T.-Y. Hsu, Y.-C. Wu*, and H.-C. Chang*, “Fluorescent nanodiamond as a probe for the intercellular transport of proteins in vivo,” Biomaterials 34, 8352–8360 (2013).
L.-J. Su, C.-Y. Fang, Y.-T. Chang, K.-M. Chen, Y.-C. Yu, J.-H. Hsu*, and H.-C. Chang*, “Creation of high density ensembles of nitrogen-vacancy centers in nitrogen-rich type Ib nanodiamonds,” Nanotechnology 24, 315702 (2013) (9pp).
A. Ermakova, G. Pramanik, J.-M. Cai, G. Algara-Siller, U. Kaiser, T. Weil, Y.-K. Tzeng, H.-C. Chang, L. P. McGuinness, M. B. Plenio, B. Naydenov*, and F. Jelezko, “Detection of a few metallo-protein molecules using color centers in nanodiamonds,” Nano Lett. 13, 3305−3309 (2013).
C. Xiong, X. Zhou, J. Wang, N. Zhang, W.-P. Peng, H.-C. Chang, and, Z. Nie*, “Ambient aerodynamic desorption/ionization method for microparticle mass measurement,” Anal. Chem. 85, 4370−4375 (2013).
C.-C. Hsieh, J. Y. Guo, S.-U. Hung, R. Chen, Z. Nie, H.-C. Chang, and C.-C. Wu*, “Quantitative analysis of oligosaccharides derived from sulfated glycosaminoglycans by nanodiamond-based affinity purification and MALDI MS,” Anal. Chem. 85, 4342–4349 (2013).
N. D. Lai*, O. Faklaris, D. Zheng, V. Jacques, H.-C. Chang, J.-F. Roch, and F. Treussart*, “Quenching nitrogen-vacancy center photoluminescence with infrared pulsed laser,” New J. Phys. 15, 033030 (2013) (14pp).
T. Zhang, H. Cui, C.-Y. Fang, L.-J. Su, S. Ren, H.-C. Chang, X. Yang, and M. L. Forrest*, “Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance,” J. Biomed. Opt. 18, 026018 (2013) (6pp).
C. M. T. Campbell, M. T. Fontana, B. C. Taggart, M.-C. Su*, C.-L. Lin, H.-C. Chang, and H.-J. Chen, “Acid denaturation and refolding of cytochrome c on silica surface,” J. Chin. Chem. Soc. 60, 140–152 (2013).
Y. Y. Hui, Y.-C. Lu, L.-J. Su, C.-Y. Fang, J.-H. Hsu, and H.-C. Chang*, “Tip-enhanced sub-diffraction fluorescence imaging of nitrogen-vacancy centers in nanodiamonds,” Appl. Phys. Lett. 102, 013102 (2013) (4pp).
S.-W. Chou, G.-R. Shiu, H.-C. Chang, and W.-P. Peng*, “Wavelet-based method for time-domain noise analysis and reduction in a frequency-scan quadrupole ion trap mass spectrometer,” J. Am. Soc. Mass Spectrom. 23, 1855–1864 (2012).
V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012).
L.-H. Chen, T.-S. Lim*, and H.-C. Chang, “Measuring the number of (N-V)− centers in single fluorescent nanodiamonds in the presence of quenching effects,” J. Opt. Soc. Am. B 29, 2309–2313 (2012).
B. Zhang, C.-Y. Fang, C.-C. Chang, R. Peterson, S. Maswadi, R. D. Glickman, H.-C. Chang, and J. Y. Ye*, “Photoacoustic emission from fluorescent nanodiamonds enhanced with gold nanoparticles,” Biomed. Opt. Express 3, 1662–1669 (2012).
R. Chen, C. Xiong, X. Zhou, C.-C. Wu*, X. Ding, Z. Nie*, and H.-C. Chang, “N-(1-naphthyl) ethylenediamine dinitrate: A new matrix for negative ion MALDI-TOF MS analysis of small molecules,” J. Am. Soc. Mass Spectrom. 23, 1454–1460 (2012).
X. Y. Zhou, C. Q. Xiong, J. N. Wang, R. Chen, Y. Tang, H. X. Qiao, W.-P. Peng, H.-C. Chang, and Z. X. Nie*, “The development of charge detection quadrupole ion trap mass spectrometry (CD-ITMS) driven by rectangular and triangular waves,” Analyst 137, 1199–1204 (2012).
R. Chen, W. J. Xu, C. Q. Xiong, X. Y. Zhou, S. X. Xiong, Z. X. Nie*, L. Q. Mao, and H.-C. Chang*, “High-salt-tolerance matrix for facile detection of glucose in rat brain microdialysates by MALDI mass spectrometry,” Anal. Chem. 84, 465–469 (2012).
C.-Y. Fang, V. Vaijayanthimala, C.-A. Cheng, S.-H. Yeh, C.-F. Chang, C.-L. Li, and H.-C. Chang*, “The exocytosis of fluorescent nanodiamond and its use as a long-term cell tracker,” Small 7, 3363–3370 (2011).
C. Q. Xiong, X. Y. Zhou, R. Chen, Y. M. Zhang, W.-P. Peng, Z. X. Nie*, H.-C. Chang, H. W. Liu*, and Y. Chen, “Characterization of column packing materials in high-performance liquid chromatography by charge-detection quadrupole ion trap mass spectrometry,” Anal. Chem. 83, 5400–5406 (2011).
M. Yamanaka, Y.-K. Tzeng, S. Kawano, N. I. Smith, S. Kawata, H.-C. Chang, and K. Fujita*, “SAX microscopy with fluorescent nanodiamond probes for high-resolution fluorescence imaging,” Biomed. Opt. Express 2, 1946–1954 (2011).
J.-H. Hsu*, W.-D. Su, K.-L. Yang, Y.-K. Tzeng, and H.-C. Chang, “Non-blinking green emission from single H3 color centers in nanodiamonds,” Appl. Phys. Lett. 98, 193116 (2011) (3pp).
Y.-Y. Chen, H. Shu, Y. Kuo, Y.-K. Tzeng, and H.-C. Chang*, “Measuring Förster resonance energy transfer between fluorescent nanodiamonds and near-infrared dyes by acceptor photobleaching,” Diamond Relat. Mater. 20, 803–807 (2011).
Y. Y. Hui*, Y.-R. Chang, N. Mohan, T.-S. Lim, Y.-Y. Chen, and H.-C. Chang*, “Polarization modulation spectroscopy of single fluorescent nanodiamonds with multiple nitrogen-vacancy centers,” J. Phys. Chem. A 115, 1878–1884 (2011).
Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
L. Rondin, G. Dantelle*, A. Slablab, F. Treussart, P. Bergonzo, S. Perruchas, T. Gacoin, H.-C. Chang, V. Jacques*, and J.-F. Roch, “Surface-induced charge state conversion of nitrogen-vacancy defects in nanodiamonds,” Phys. Rev. B 82, 115449 (2010) (5pp).
N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
Y.-C. Chang, C.-N. Huang, C.-H. Lin, H.-C. Chang, and C.-C. Wu*, “Mapping protein cysteine sulfonic acid modifications with specific enrichment and mass spectrometry: An integrated approach to explore the cysteine oxidation,” Proteomics 10, 2961−2971 (2010).
Y. Y. Hui, B. Zhang, Y.-C. Chang, C.-C. Chang, H.-C. Chang*, J.-H. Hsu, K. Chang, and F.-H. Chang, “Two-photon fluorescence correlation spectroscopy of lipid-encapsulated fluorescent nanodiamonds in living cells,” Opt. Express 18, 5896–5905 (2010).
N. Mohan, Y.-K. Tzeng, L. Yang, Y.-Y. Chen, Y. Y. Hui, C.-Y. Fang, and H.-C. Chang*, “Sub-20-nm fluorescent nanodiamonds as photostable biolabels and fluorescence resonance energy transfer donors,” Adv. Mater. 22, 843–847 (2010).
B. Zhang, Y. Li, C.-Y. Fang, C.-C. Chang, C.-S. Chen, Y.-Y. Chen, and H.-C. Chang*, “Receptor-mediated cellular uptake of folate-conjugated fluorescent nanodiamonds: A combined ensemble and single-particle study,” Small 5, 2716–2721 (2009).
X. L. Kong, C. Lin, G. Infusini, H.-B. Oh, H. Jiang, K. Breuker, C.-C. Wu, O. P. Charkin, H.-C. Chang, and F. W. McLafferty*, “Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy,” ChemPhysChem 10, 2603–2606 (2009).
V. Vaijayanthimala, Y.-K. Tzeng, H.-C. Chang*, and C.-L. Li*, “The biocompatibility of fluorescent nanodiamonds and their mechanism of cellular uptake,” Nanotechnology 20, 425103 (2009) (9pp).
A. Zyubin, A. M. Mebel*, M. Hayashi, H.-C. Chang, and S.-H. Lin, “Quantum chemical modeling of photoabsorption properties of the two- and three-nitrogen-vacancy point defects in diamond,” J. Phys. Chem. C 113, 10432–10440 (2009).
C.-K. Lin*, H.-C. Chang, M. Hayashi, and S. H. Lin, “Excitation properties of the H3 defect center in diamond: A theoretical study,” Chem. Phys. Lett. 475, 68–72 (2009).
Y.-K. Tzeng, Z. Zhu, and H.-C. Chang*, “Alkali-hydroxide-doped matrices for structural characterization of neutral underivatized oligosaccharides by MALDI time-of-flight mass spectrometry,” J. Mass Spectrom. 44, 375–383 (2009).
T.-S. Lim, C.-C. Fu, K.-C. Lee, H.-Y. Lee, K. Chen, W.-F. Cheng, W. W. Pai, H.-C. Chang*, and W. Fann, “Fluorescence enhancement and lifetime modification of single nanodiamonds near a nanocrystalline silver surface,” Phys. Chem. Chem. Phys. 11, 1508–1514 (2009).
T.-L. Wee, Y.-W. Mau, C.-Y. Fang, H.-L. Hsu, C.-C. Han, and H.-C. Chang*, “Preparation and characterization of green fluorescent nanodiamonds for biological applications,” Diamond Relat. Mater. 18, 567–573 (2009).
A. S. Zyubin, A. M. Mebel*, M. Hayashi, H.-C. Chang, and S. H. Lin, “Quantum chemical modeling of photoabsorption properties of the nitrogen-vacancy point defect in diamond,” J. Comput. Chem. 30, 119–131 (2009).
Y. Y. Hui*, Y.-R. Chang*, T.-S. Lim, H.-Y. Lee, W. Fann, and H.-C. Chang*, “Quantifying the number of color centers in single fluorescent nanodiamonds by photon correlation spectroscopy and Monte Carlo simulation,” Appl. Phys. Lett. 94, 013104 (2009) (3pp).
A. S. Zyubin, A. M. Mebel*, H.-C. Chang, and S. H. Lin, “Potential energy surfaces for the lowest excited states of the nitrogen-vacancy point defects in diamonds: A quantum chemical study,” Chem. Phys. Lett. 462, 251–255 (2008).
C.-K. Lin*, Y.-H. Wang, H.-C. Chang, and S. H. Lin, “One- and two-photon absorption properties of diamond nitrogen-vacancy defect centers: A theoretical study,” J. Chem. Phys. 129, 124714 (2008).
Y.-K. Tzeng, C.-C. Chang, C.-N. Huang, C.-C. Wu, C.-C. Han, and H.-C. Chang*, “Facile MALDI-MS analysis of neutral glycans in NaOH-doped matrices: Microwave-assisted deglycosylation and one-step purification with diamond nanoparticles,” Anal. Chem. 80, 6809–6814 (2008).
C.-K. Chang, C.-C. Wu*, Y.-S. Wang, and H.-C. Chang, “Selective extraction and enrichment of multi-phosphorylated peptides using polyarginine-coated diamond nanoparticles,” Anal. Chem. 80, 3791–3797 (2008).
Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nat. Nanotechnol. 3, 284–288 (2008).
W.-P. Peng, H.-C. Lin, M. Chu, H.-C. Chang, H.-H. Lin, A. L Yu, and C.-H. Chen*, “Charge monitoring cell mass spectrometry,” Anal. Chem. 80, 2524–2530 (2008).
Z. X. Nie, F. P. Cui, M. Chu, C.-H. Chen, H.-C. Chang*, and Y. Cai*, “Calibration of a frequency-scan quadrupole ion trap mass spectrometer for microparticle mass analysis,” Int. J. Mass Spectrom. 270, 8–15 (2008).
Z. X. Nie, F. P. Cui, Y.-K. Tzeng, H.-C. Chang*, M. Chu, H.-C. Lin, C.-H. Chen, H.-H. Lin, and A. L. Yu, “High-speed mass analysis of whole erythrocytes by charge detection quadrupole ion trap mass spectrometry,” Anal. Chem. 79, 7401–7407 (2007).
C. M. Kraning, T. L. Benz, K. S. Bloome, G. C. Campanello, V. S. Fahrenbach, S. A. Mistry, C. A. Hedge, K. D. Clevenger, K. M. Gligorich, T. A. Hopkins*, G. C. Hoops*, S. B. Mendes, H.-C. Chang, and M.-C. Su*, “Determination of surface coverage and orientation of reduced cytochrome c on a silica surface with polarized ATR spectroscopy,” J. Phys. Chem. C 111, 13062–13067 (2007).
T.-L. Wee, Y.-K. Tzeng, C.-C. Han, H.-C. Chang*, W. Fann, J.-H. Hsu*, K.-M. Chen, and Y.-C. Yu, “Two-photon excited fluorescence of nitrogen-vacancy centers in proton-irradiated type Ib diamond,” J. Phys. Chem. A 111, 9379–9386 (2007).
C.-K. Lin*, H.-C. Chang, and S. H. Lin, “Symmetric double-well potential model and its application to vibronic spectra: Studies of inversion modes of ammonia and nitrogen-vacancy defect centers in diamond,” J. Phys. Chem. A 111, 9347–9354 (2007).
O. P. Charkin*, N. M. Klimenko, D. O. Charkin, H.-C. Chang, and S. H. Lin, “Theoretical DFT study of fragmentation and association of heme and hemin,” J. Phys. Chem. A 111, 9207–9217 (2007).
S. Sabu, F.-C. Yang, Y.-S. Wang, W.-H. Chen, H.-C. Chang, and C.-C. Han*, “Peptide analysis: Solid phase extraction-elution on diamond (SPEED) combined with atmospheric pressure MALDI-FTICR mass spectrometry,” Anal. Biochem. 367, 190–200 (2007).
W.-P. Peng, H.-C. Lin, H.-H. Lin, M.-L. Chu, A. L. Yu, H.-C. Chang, and C.-H. Chen*, “Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement,” Angew. Chem. Int. Ed. 46, 3865–3869 (2007).
T. T. B. Nguyen, H.-C. Chang*, and V. W.-K. Wu, “Adsorption and hydrolytic activity of lysozyme on diamond nanocrystallites,” Diamond Relat. Mater. 16, 872–876 (2007).
K. K. Liang*, C.-K. Lin, H.-C. Chang, A. A. Villaeys, M. Hayashi, and S. H. Lin, “Calculation of the vibrationally non-relaxed photo-induced electron transfer rate constant in dye-sensitized solar cells,” Phys. Chem. Chem. Phys. 9, 853–861 (2007).
C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727–732 (2007).
W.-C. Chang, L.-C. L. Huang, Y.-S. Wang, W.-P. Peng, H.-C. Chang, N.-Y. Hsu, W.-B. Yang, and C.-H. Chen*, “Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited,” Anal. Chim. Acta 582, 1–9 (2007).
Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
K. K. Liang*, C.-K. Lin, H.-C. Chang, M. Hayashi, and S. H. Lin, “Theoretical treatments of ultrafast electron transfer from adsorbed dye molecule to semiconductor nanocrystalline surface,” J. Chem. Phys. 125, 154706 (2006) (16pp).
Y.-S. Wang, S. Sabu, S.-C. Wei, C.-M. J. Kao, X. L. Kong, S.-C. Liau, C.-C. Han, H.-C. Chang*, S.-Y. Tu, A. H. Kung, and J. Z. H. Zhang, “Dissociation of heme from gaseous myoglobin ions studied by infrared multiphoton dissociation spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry,” J. Chem. Phys. 125, 133310 (2006) (7pp).
W.-H. Chen, S.-C. Lee, S. Sabu, H.-C. Fang, S.-C. Chung, C.-C. Han*, and H.-C. Chang*, “Solid phase extraction and elution on diamond (SPEED): A fast and general platform for proteome analysis with mass spectrometry,” Anal. Chem. 78, 4228–4234 (2006).
X. L. Kong, I.-A. Tsai, S. Sabu, C.-C. Han, Y. T. Lee, H.-C. Chang*, S.-Y. Tu, A. H. Kung, and C.-C. Wu, “Progressive stabilization of zwitterionic structures in H+(Ser)2-8 studied by infrared photodissociation spectroscopy,” Angew. Chem. Int. Ed. 45, 4130–4135 (2006).
H.-C. Chang*, K. Chen, and S. Kwok*, “Nanodiamond as a possible carrier of extended red emission,” Astrophys. J. 639, L63–L66 (2006).
Z. X. Nie, C.-W. Lin, W.-P. Peng, Y. T. Lee, and H.-C. Chang*, “Frequency scan of a quadrupole mass analyzer in the third stability region for protein analysis,” J. Chin. Chem. Soc. 53, 47–52 (2006).
W.-P. Peng, Y.-C. Yang, M.-W. Kang, Y.-K. Tzeng, Z. X. Nie, H.-C. Chang*, W. Chang, and C.-H. Chen, “Laser-induced acoustic desorption mass spectrometry of single bioparticles,” Angew. Chem. Int. Ed. 45, 1423–1426 (2006).
S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
O. P. Charkin*, N. M. Klimenko, P. T. Nguyen, D. O. Charkin, A. M. Mebel, S. H. Lin, Y.-S. Wang, S.-C. Wei, and H.-C. Chang, “Fragmentation of heme and hemin+ with sequential loss of carboxymethyl groups: A DFT and mass-spectrometry study,” Chem. Phys. Lett. 415, 362–369 (2005).
W.-P. Peng, Y.-C. Yang, C.-W. Lin, and H.-C. Chang*, “Molar mass and molar mass distribution of polystyrene particle size standards,” Anal. Chem. 77, 7084–7089 (2005).
O. P. Charkin*, N. M. Klimenko, P. T. Nguyen, D. O. Charkin, Y.-S. Wang, S.-C. Wei, H.-C. Chang, and S. H. Lin, “Theoretical study of fragmentation of heme and its ion with successive removal of carboxymethyl groups,” Russ. J. Inorg. Chem. 50, 1398–1407 (2005).
X. L. Kong, L. C. L. Huang, S.-C. V. Liau, C.-C. Han, and H.-C. Chang*, “Polylysine-coated diamond nanocrystals for MALDI-TOF mass analysis of DNA oligonucleotides,” Anal. Chem. 77, 4273–4277 (2005).
C.-K. Lin, C.-C. Wu, Y.-S. Wang, Y. T. Lee, H.-C. Chang*, J.-L. Kuo*, and M. L. Klein, “Vibrational predissociation spectra and hydrogen-bond topologies of H+(H2O)9-11,” Phys. Chem. Chem. Phys. 7, 938–944 (2005).
C.-C. Wu, C.-K. Lin, H.-C. Chang*, J. C. Jiang, J.-L. Kuo*, and M. L. Klein, “Protonated clathrate cages enclosing neutral water molecules: H+(H2O)21 and H+(H2O)28,” J. Chem. Phys. 122, 074315 (2005) (9pp).
W.-P. Peng, Y. T. Lee, J. W. Ting*, and H.-C. Chang*, “Averaging peak-to-peak voltage detector for absolute mass determination of single particles with quadrupole ion traps,” Rev. Sci. Instrum. 76, 023108 (2005) (5pp).
X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
J.-W. Wang*, Y.-M. Chang, H.-C. Chang, S.-H. Lin, L.-C. L. Huang, X.-L. Kong, and M.-W. Kang, “Local structure dependence of the charge transfer band in nanocrystalline Y2O3: Eu3+,” Chem. Phys. Lett. 405, 314–317 (2005).
C. Chaudhuri, C.-C. Wu, J. C. Jiang, and H.-C. Chang*, “Comparative studies of H+(C6H6)(H2O)1,2 and H+(C5H5N)(H2O)1,2 by DFT calculations and IR spectroscopy,” Aust. J. Chem. 57, 1153–1156 (2004).
W.-P. Peng, Y.-C. Yang, M.-W. Kang, Y. T. Lee, and H.-C. Chang*, “Measuring masses of single bacterial whole cells with a quadrupole ion trap,” J. Am. Chem. Soc. 126, 11766–11767 (2004).
Y.-Y. Cheng, H.-C. Chang*, G. C. Hoops, and M.-C. Su, “Stabilization of yeast cytochrome c covalently immobilized on fused silica surfaces,” J. Am. Chem. Soc. 126, 10828–10829 (2004).
L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
C.-C. Wu, Y.-S. Wang, C. Chaudhuri, J. C. Jiang, and H.-C. Chang*, “Microsolvation of the lithium ion by methanol in the gas phase,” Chem. Phys. Lett. 388, 457–462 (2004).
C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “Structural isomerism and competitive proton solvation between methanol and water in H+(CH3OH)m(H2O)n, m + n = 4,” J. Phys. Chem. A 108, 2859–2866 (2004).
A. P. Jones*, L. B. d’Hendecourt, S.-Y. Sheu, H.-C. Chang, C.-L. Cheng, and H. G. M. Hill, “Surface C-H stretching features on meteoritic nanodiamonds,” Astron. Astrophys. 416, 235–241 (2004).
Y.-Y. Cheng, S. H. Lin, H.-C. Chang*, and M.-C. Su, “Probing adsorption, orientation and conformational changes of cytochrome c on fused silica surfaces with the Soret band,” J. Phys. Chem. A 107, 10687–10694 (2003).
Y.-R. Chen, H.-C. Chang*, C.-L. Cheng, C.-C. Wang, and J. C. Jiang, “Size dependence of CH stretching features on diamond nanocrystal surfaces: Infrared spectroscopy and density functional theory calculations,” J. Chem. Phys. 119, 10626–10632 (2003).
W.-P. Peng, Y. Cai, Y. T. Lee, and H.-C. Chang*, “Laser-induced fluorescence/ion trap as a detector for mass spectrometric analysis of nanoparticles,” Int. J. Mass Spectrom. 229, 67–76 (2003).
C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “Hydration-induced conformational changes in protonated 2,4-pentanedione in the gas phase,” Mol. Phys. 101, 1285–1298 (2003).
K.-Y. Kim, H.-C. Chang*, Y. T. Lee, U.-I. Cho, and D. W. Boo, “Vibrational predissociation spectroscopic and ab initio theoretical studies on protonated ethylenediamine-(water)3 complex,” J. Phys. Chem. A 107, 5007–5013 (2003).
Y.-S. Wang, C.-H. Tsai, Y. T. Lee, H.-C. Chang*, J. C. Jiang, O. Asvany, S. Schlemmer, and D. Gerlich, “Investigations of protonated and deprotonated water clusters using a low-temperature 22-pole ion trap,” J. Phys. Chem. A 107, 4217–4225 (2003).
Y. Cai, W.-P. Peng, and H.-C. Chang*, “Ion trap mass spectrometry of fluorescently labeled nanoparticles,” Anal. Chem. 75, 1805–1811 (2003).
S.-Y. Sheu, I.-P. Lee, Y. T. Lee, and H.-C. Chang*, “Laboratory investigations of hydrogenated diamond surfaces by infrared spectroscopy: Implications for the formation and size of interstellar nanodiamonds,” Astrophys. J. 581, L55–L58 (2002).
J. C. Jiang, C. Chaudhuri, Y. T. Lee, and H.-C. Chang*, “Hydrogen bond rearrangements and interconversions of H+(CH3OH)4H2O cluster isomers,” J. Phys. Chem. A 106, 10937–10944 (2002).
C.-C. Wu, C. Chaudhuri, J. C. Jiang, Y. T. Lee, and H.-C. Chang*, “On the first overtone spectra of protonated water clusters [H+(H2O)3-5] in the free-OH stretch region,” J. Chin. Chem. Soc. 49, 769–775 (2002).
Y. Cai, W.-P. Peng, S.-J. Kuo, S. Sabu, C.-C. Han, and H.-C. Chang*, “Optical detection and charge-state analysis of MALDI-generated particles with molecular masses larger than 5 MDa,” Anal. Chem. 74, 4434–4440 (2002).
Y. Cai, W.-P. Peng, S.-J. Kuo, and H.-C. Chang*, “Calibration of an audio-frequency ion trap mass spectrometer,” Int. J. Mass Spectrom. 214, 63–73 (2002).
C.-F. Chen, C.-C. Wu, C.-L. Cheng, S.-Y. Sheu, and H.-C. Chang*, “The size of interstellar nanodiamonds revealed by infrared spectra of CH on synthetic diamond nanocrystal surfaces,” J. Chem. Phys. 116, 1211–1214 (2002).
Y. Cai, W.-P. Peng, S.-J. Kuo, Y. T. Lee, and H.-C. Chang*, “Single-particle mass spectrometry of polystyrene microspheres and diamond nanocrystals,” Anal. Chem. 74, 232–238 (2002).
C. Chaudhuri, J. C. Jiang, C.-C. Wu, X. Wang, and H.-C. Chang*, “Characterization of protonated formamide-containing clusters by infrared spectroscopy and ab initio calculations: II. Hydration of formamide in the gas phase,” J. Phys. Chem. A 105, 8906–8915 (2001).
C. Chaudhuri, Y.-S. Wang, J. C. Jiang, Y. T. Lee, H.-C. Chang*, and G. Niedner-Schatteburg, “Infrared spectra and isomeric structures of hydroxide-water cluster ions OH–(H2O)1-5: A comparison with H3O+(H2O)1-5,” Mol. Phys. 99, 1161–1173 (2001).
Y. D. Glinka*, K.-W. Lin, H.-C. Chang, S. H. Lin, and Y. T. Chen, “Power laser light-induced photoluminescence from detonation-synthesized 5nm-sized diamonds,” Defect Diffusion Forum 186-187, 37–44 (2000).
C.-C. Wu, J. C. Jiang, I. Hahndorf, C. Chaudhuri, Y. T. Lee, and H.-C. Chang*, “Characterization of protonated formamide-containing clusters by infrared spectroscopy and ab initio calculations: I. O-protonation,” J. Phys. Chem. A 104, 9556–9565 (2000).
C. Chaudhuri, J. C. Jiang, X. Wang, Y. T. Lee, and H.-C. Chang*, “Identification of CH3OH2+- and H3O+-centered isomers from fragment-dependent vibrational predissociation spectra of H+(CH3OH)4H2O,” J. Chem. Phys. 112, 7279–7282 (2000).
J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
H.-C. Chang*, J. C. Jiang, H.-C. Chang, L. R. Wang, and Y. T. Lee, “Hydrogen bond rearrangement and intermolecular proton transfer in protonated methanol clusters,” Israel J. Chem. 39, 231–243 (2000).
C.-C. Wu, J. C. Jiang, D. W. Boo, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Behaviors of an excess proton in solute-containing water clusters: A case study of H+(CH3OH)(H2O)1-6,” J. Chem. Phys. 112, 176–188 (2000).
I. Hahndorf, J. C. Jiang, H.-C. Chang, C.-C. Wu, and H.-C. Chang*, “Proton-assisted hydration at hydrophobic sites in protonated ether and keto dimers,” J. Phys. Chem. A 103, 8753–8761 (1999).
H.-C. Chang*, J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, and Y. T. Lee, “On the search for H5O2+-centered water clusters in the gas phase,” J. Chin. Chem. Soc. 46, 427–434 (1999).
R. Chang, J. C. Jiang, P.-J. Hsieh, H.-C. Chang, and S. H. Lin*, “Theory of vibrational predissociation spectroscopy,” J. Chin. Chem. Soc. 46, 417–426 (1999).
Y. D. Glinka, K.-W. Lin, H.-C. Chang, and S. H. Lin*, “Multiphoton-excited luminescence from diamond nanoparticles,” J. Phys. Chem. B 103, 4251–4263 (1999).
H.-C. Chang, J. C. Jiang, I. Hahndorf, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Migration of an excess proton upon asymmetric hydration: H+[(CH3)2O](H2O)n as a model system,” J. Am. Chem. Soc. 121, 4443–4450 (1999).
J. C. Jiang, H.-C. Chang, Y. T. Lee, and S. H. Lin*, “Ab initio studies of NH4+(H2O)1-5 and the influence of hydrogen-bonding nonadditivity on geometries and vibrations,” J. Phys. Chem. A 103, 3123–3135 (1999).
H.-C. Chang, J. C. Jiang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Isomeric transitions between linear and cyclic H+(CH3OH)4,5: Implications for proton migration in liquid methanol,” J. Phys. Chem. A 103, 2941–2944 (1999).
H.-C. Chang, Y.-S. Wang, Y. T. Lee, and H.-C. Chang*, “Studying protonated ion hydration by infrared spectroscopy of size-selected NH4+(H2O)n clusters in a free jet expansion,” Int. J. Mass Spectrom. 179/180, 91–102 (1998).
C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Vibrational predissociation dynamics of ArHF (3000) and (3110): Lifetimes and HF product state distributions,” J. Chem. Phys. 109, 8836–8841 (1998).
Y.-S. Wang, H.-C. Chang, J. C. Jiang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Structures and isomeric transitions of NH4+(H2O)3-6: From single to double rings,” J. Am. Chem. Soc. 120, 8777–8788 (1998).
K.-W. Lin, C.-L. Cheng, and H.-C. Chang*, “Laser-induced intracluster reactions of oxygen-containing nanodiamonds,” Chem. Mater. 10, 1735–1737 (1998).
C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Vibrational predissociation of an inert gas cluster containing an active molecule: The vHF = 3 spectrum of Ar3HF,” J. Chem. Phys. 109, 484–491 (1998).
J. C. Jiang, J.-C. Chang, B.-C. Wang, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “The free-OH stretching frequencies of 3-coordinated H2O in water clusters and on ice surfaces,” Chem. Phys. Lett. 289, 373–382 (1998).
Y.-S. Wang, J. C. Jiang, C.-L. Cheng, S. H. Lin, Y. T. Lee, and H.-C. Chang*, “Identifying 2- and 3-coordinated H2O in protonated ion-water clusters by vibrational predissociation spectroscopy and ab initio calculations,” J. Chem. Phys. 107, 9695–9698 (1997).
C.-C. Chuang, S. N. Tsang, J. G. Hanson, W. Klemperer*, and H.-C. Chang, “Laser-induced fluorescence spectroscopy of Ar2HF at vHF = 3: An examination of three-body forces,” J. Chem. Phys. 107, 7041–7056 (1997).
C.-C. Chuang, S. N. Tsang, W. Klemperer*, and H.-C. Chang, “Reassignment of the 11537 cm-1 band of hydrogen fluoride dimer and observation of the intermolecular combination mode 3ν1+ν4,” J. Phys. Chem. 101, 6702–6708 (1997).
C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3713–3716 (1997).
C.-L. Cheng, J.-C. Lin*, and H.-C. Chang*, “The absolute absorption strength and vibrational coupling of CH stretching on diamond C(111),” J. Chem. Phys. 106, 7411–7421 (1997).
W.-K. Liu, M. Hayashi, J.-C. Lin, H.-C. Chang, S. H. Lin*, and J.-K. Wang, “Effect of temperature on the infrared and sum-frequency generation spectra of adsorbates,” J. Chem. Phys. 106, 5920–5927 (1997).
C.-L. Cheng, J.-C. Lin*, H.-C. Chang*, and J.-K Wang, “Characterization of CH stretches on diamond C(111) single- and nanocrystals by infrared absorption spectroscopy,” J. Chem. Phys. 105, 8977–8978 (1996).
S. N. Tsang, C.-C. Chuang, R. Mollaaghababa, W. Klemperer*, and H.-C. Chang, “Intermolecular state dependence of the vibrational predissociation of N2-HF,” J. Chem. Phys. 105, 4385–4387 (1996).
J.-C. Lin*, K.-H. Chen, H.-C. Chang*, C.-S. Tsai, C.-E. Lin, and J.-K. Wang*, “The vibrational dephasing and relaxation of CH and CD stretches on diamond surfaces: An anomaly,” J. Chem. Phys. 105, 3975–3983 (1996).
H.-C. Chang* and W. Klemperer*, “A phenomenological model for the vibrational dependence of hydrogen interchange tunneling in HF dimer,” J. Chem. Phys. 104, 7830–7835 (1996).
H.-C. Chang* and J.-C. Lin*, “Structure and bonding of C2H2 on diamond C(111)-1x1:H: Infrared spectroscopy and exciton calculations,” J. Phys. Chem. 100, 7018–7025 (1996).
H.-C. Chang* and J.-C. Lin, “Infrared spectroscopy of adsorbed CO2 as a probe for the surface heterogeneity of diamond C(111)-1x1:H,” Appl. Phys. Lett. 67, 2474–2476 (1995).
H.-C. Chang*, J.-C. Lin, J.-Y. Wu, and K.-H. Chen, “Infrared spectroscopy and vibrational relaxation of CHx and CDx stretches on synthetic diamond nanocrystal surfaces,” J. Phys. Chem. 99, 11081–11088 (1995).
H.-C. Chang*, D. J. Dai, and G. E. Ewing, “Vibrational spectroscopy as a probe of surface heterogeneity: CO on NaCl(100),” J. Chin. Chem. Soc. 42, 317–324 (1995).
H.-C. Chang, F.-M. Tao, S. N. Tsang, and W. Klemperer*, “Dependence of the intermolecular potentials of ArHF and N2HF on HF bond length,” J. Chin. Chem. Soc. 42, 141–148 (1995).
R. Mollaaghababa, H.-C. Chang, and W. Klemperer*, “Vibrational predissociation of HFHCl by overtone excitation of HF,” Can. J. Phys. 72, 693–696 (1994).
S. N. Tsang, H.-C. Chang, and W. Klemperer*, “Characterization of N2HF at 3ν1 HF stretch,” J. Phys. Chem. 98, 7313–7318 (1994).
H.-C. Chang and W. Klemperer*, “High overtone spectroscopy and photodissociation of hydrogen fluoride complexes,” Faraday Discuss. 97, 95–103 (1994).
H.-C. Chang and W. Klemperer*, “The vibrational second overtones of HF dimer: A quartet,” J. Chem. Phys. 100, 1–14 (1994).
H.-C. Chang, F.-M. Tao, W. Klemperer*, C. Healey, and J. M. Hutson, “The Ar-HF intermolecular potential: Overtone spectroscopy and ab initio calculations,” J. Chem. Phys. 99, 9337–9349 (1993).
H.-C. Chang and W. Klemperer*, “State-specific vibrational predissociation and interconversion tunneling quenching at 3ν1 and 3ν2 of (HF)2,” J. Chem. Phys. 98, 9266–9278 (1993).
H.-C. Chang and W. Klemperer*, “Observation of ArHF(3000) and its combination modes by laser-induced fluorescence,” J. Chem. Phys. 98, 2497–2506 (1993).
H.-C. Chang and G. E. Ewing*, “Vibrational relaxation of molecules on alkali halide surfaces,” Proceedings Vibrations at Surfaces, New York, 1990; also in J. Electron Spectrosc. Relat. Phenom. 54, 39–63 (1990).
R. S. Disselkamp, H.-C. Chang, and G. E. Ewing*, “Infrared spectroscopy of CO on NaCl(100): IV. Bandshape analysis,” Surf. Sci. 240, 193–210 (1990).
H.-C. Chang and G. E. Ewing*, “Infrared fluorescence from a monolayer of CO on NaCl(100),” Phys. Rev. Lett. 65, 2125–2128 (1990).
H.-C. Chang and G. E. Ewing*, “Vibrational energy transfer and population inversion in CO overlayers on NaCl(100),” J. Phys. Chem. 94, 7635–7641 (1990).
H.-C. Chang, C. Noda, and G. E. Ewing*, “CO on NaCl(100): Model system for investigating vibrational energy flow,” J. Vac. Sci. Technol. A8, 2644–2648 (1990).
H.-C. Chang and G. E. Ewing*, “The quantum efficiency of vibrationally induced desorption for a monolayer of CO on NaCl(100),” Chem. Phys. 139, 55–65 (1989).
H. H. Richardson, H.-C. Chang, C. Noda, and G. E. Ewing*, “Infrared spectroscopy of CO on NaCl(100): I. Photometry,” Surf. Sci. 216, 93–104 (1989).
H.-C. Chang, H. H. Richardson, and G. E. Ewing*, “Epitaxial growth of CO on NaCl(100) studied by infrared spectroscopy,” J. Chem. Phys. 89, 7561–7568 (1988).
H.-C. Chang and K.-H. Houng*, “DMSO intercalation as a method in the identification of kaolinite from chlorite in soil clay samples,” Bull. Inst. Chem. Acad. Sinica 31, 31–39 (1984).

Review Articles (20)

Y. Y. Hui*, T.-N. Le, T.-I. Yang, J. Chen*, and H.-C. Chang, “Emerging trends in fluorescent nanodiamond quantum sensing,” Nano Futures 8, 042001 (2024) (16pp).
W. W.-W. Hsiao*, X. M. Lam, T.-N. Le, C.-A. Cheng*, and H.-C. Chang, “Exploring nanodiamonds: Leveraging their dual capacities for anticancer photothermal therapy and temperature sensing,” Nanoscale 16, 14994–15008 (2024).
S. Angela, G, Fadhilah, H.-Y. Lin, J. Ko, S. C.-W. Lu, C.-C. Lee, Y.-S. Chang, C.-Y. Lin, H.-C. Chang, W. W.-W. Hsiao*, and W.-H. Chiang, “Nanomaterials in the treatment and diagnosis of rheumatoid arthritis: Advanced approaches,” SLAS Technol. 29, 100146 (2024) (13pp).
W. W.-W. Hsiao*, G. Fadhilah, C.-C. Lee, R. Endo, Y.-J. Lin, S. Angela, C.-C. Ku, H.-C. Chang, and W.-H. Chiang*, “Nanomaterial-based biosensors for avian influenza virus: A new way forward,” Talanta 265, 124892 (2023) (14pp).
W. W.-W. Hsiao*, T.-N. Le, D. M. Pham, H.-H. Ko, H.-C. Chang, C.-K. Lee*, and W.-H. Chiang*, “Recent advances in novel lateral flow technologies for detection of COVID-19,” Biosensors 11, 295 (2021) (26pp).
W.-Z. Zhuang, Y.-H. Lin, L.-J. Su, M.-S. Wu, H.-Y. Jeng, H.-C. Chang, Y.-H. Huang*, and T.-Y. Ling*, “Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications,” J. Biomed. Sci. 28, 1–38 (2021).
Y.-Y. Liu, B.-M. Chang, and H.-C. Chang*, “Nanodiamond-enabled biomedical imaging,” Nanomedicine 15, 1599–1616 (2020).
C. Bradac*, S. F. Lim, H.-C. Chang, and I. Aharonovich, “Optical nanoscale thermometry: from fundamental mechanisms to emerging practical applications,” Adv. Opt. Mater. 8, 2000183 (2020) (29pp).
S. Sotoma, F.-J. Hsieh, and H.-C. Chang*, “Biohybrid fluorescent nanodiamonds as dual-contrast markers for light and electron microscopies,” J. Chin. Chem. Soc. 65, 1136–1146 (2018).
S. Sotoma, C. P. Epperla, and H.-C. Chang*, “Diamond nanothermometry,” ChemNanoMat 4, 15–27 (2018).
Y. Y. Hui, W. W.-W. Hsiao, S. Haziza, M. Simonneau, F. Treussart*, and H.-C. Chang*, “Single particle tracking of fluorescent nanodiamonds in cells and organisms,” Curr. Opin. Solid State Mater. Sci. 21, 35–42 (2017).
W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
V. Vaijayanthimala, D. K. Lee, S. V. Kim, A. Yen, N. Tsai, D. Ho*, H.-C. Chang*, and O. Shenderova*, “Nanodiamond-mediated drug delivery and imaging: challenges and opportunities,” Expert Opin. Drug Deliv. 12, 735–749 (2015).
Y. Y. Hui* and H.-C. Chang*, “Recent developments and applications of nanodiamonds as versatile bioimaging agents,” J. Chin. Chem. Soc. 61, 67–76 (2014).
Y. Y. Hui*, C.-L. Cheng*, and H.-C. Chang*, “Nanodiamonds for optical bioimaging,” J. Phys. D: Appl. Phys. 43, 374021 (2010) (11pp).
C.-C. Wu, C.-C. Han, and H.-C. Chang*, “Applications of surface-functionalized diamond nanoparticles for mass-spectrometry-based proteomics,” J. Chin. Chem. Soc. 57, 583–594 (2010).
H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
V. Vaijayanthimala and H.-C. Chang*, “Functionalized fluorescent nanodiamonds for biomedical applications,” Nanomedicine 4, 47–55 (2009).
H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
W.-P. Peng, Y. Cai, and H.-C. Chang*, “Optical detection methods for mass spectrometry of macroions,” Mass Spectrom. Rev. 23, 443–465 (2004).

Book Chapters (13)

W. W.-W. Hsiao, T.-N. Le, and H.-C. Chang, “Applications of fluorescent nanodiamond in biology,” in Encyclopedia of Analytical Chemistry, ed. J.-R. Albani (Wiley, 2022), Chap. a9776.
C. P. Epperla, H.-H. Lin, and H.-C. Chang, “Nanodiamonds and their biological applications,” in Carbon Nanostructures for Bio-Medical Applications, eds. T. Da Ros, N. Martin, and J.-F. Nierengarten (RSC, 2021), 257–292.
Y. Y. Hui, O. Y. Chen, H.-C. Chang, and M.-C. Su, in 21st Century Nanoscience – A Handbook: Exotic Nanostructures and Quantum Systems (Volume Five), ed. K. D. Sattler (CRC Press, 2020), Chap. 26, 26-1–26-18.
W. W.-W. Hsiao, H.-H. Lin, and H.-C. Chang, “Diamond nanoparticles for drug delivery and monitoring,” in Carbon-Based Nanosensor Technology, Springer Series on Chemical Sensors and Biosensors, ed. C. Kranz (Springer, 2019), 17: 119–140.
B.-M. Chang, D. Ho, and H.-C. Chang, “Biomarkers and drug delivery applications,” in Nanodiamonds: Advanced Material Analysis, Properties and Applications, ed. J.-C. Arnault (Elsevier, 2017), Chap. 16, pp. 403–417.
Y. Y. Hui, C.-A. Cheng, O. Y. Chen, and H.-C. Chang, “Bioimaging and quantum sensing using NV centers in diamond nanoparticles,” in Carbon Nanoparticles and Nanostructures, Carbon Nanostructures, eds. N. Yang, X. Jiang, and D.-W. Pang (Springer, 2016), pp. 109–137.
W. W.-W. Hsiao, H.-H. Lin, F.-J. Hsieh, and H.-C. Chang, “Surface-modified nanodiamonds,” in Carbon Nanomaterials Sourcebook: Graphene, Fullerenes, Nanotubes, and Nanodiamonds, Vol. I, ed. K. D. Sattler (CRC Press, 2016), Chap. 22, pp. 517–533.
V. Vaijayanthimala, C. P. Epperla, and H.-C. Chang, “Nanodiamonds,” in Nanoparticles for Biotherapeutic Delivery, Vol. 2, eds. J. D. Ramsey and M. L. Forrest (Future Science, 2015), Chap. 11, pp. 30–42.
N. Mohan and H.-C. Chang, “Fluorescent nanodiamonds and their prospects in bioimaging,” in Optical Engineering of Diamond, eds. R. Mildren and J. Rabeau (Wiley, 2013), Chap. 13, pp. 445–471.
V. Vaijayanthimala, Y. Y. Hui, and H.-C. Chang, “Nanodiamonds for bioimaging and therapeutic applications,” in The Nanobiotechnology Handbook, ed. Y. Xie (CRC Press, 2012), Chap. 25, pp. 537–563.
W. K. Liu, A. Adnan, A. Kopacz, M. Hallikainen, D. Ho, R. Lam, J. Lee, T. Belytschko, G. Schatz, Y. Tzeng, Y.-J. Kim, S. Baik, M. K. Kim, T. Kim, J. Lee, E.-S. Hwang, S. Im, E. Osawa, A. Barnard, H.-C. Chang, and C.-C. Chang, “Design of nanodiamond based drug delivery patch for cancer therapeutics and imaging applications,” in Nanodiamonds: Applications in Biology and Nanoscale Medicine, ed. D. Ho (Springer, 2009), Chap. 12, pp. 249–284.
H.-C. Chang, “Development and use of fluorescent nanodiamonds as cellular markers,” in Nanodiamonds: Applications in Biology and Nanoscale Medicine, ed. D. Ho (Springer, 2009), Chap. 6, pp. 127–150.
C. Su, H.-C. Chang, J.-K. Wang, and J.-C. Lin, “Hydrogen chemistry on diamond surfaces: Adsorption, desorption, and vibrational spectroscopy,” in Handbook of Surfaces and Interfaces of Materials, Vol. 2, ed. H. S. Nalwa (Academic Press, 2001), Chap. 8, pp. 315–355.

Conference Proceedings (7)

S. Sotoma*, F.-J. Hsieh, Y.-W. Chen, J. Chen, K. Wardhani, P.-C. Tsai, and H.-C. Chang*, “Characterization and applications of fluorescent nanodiamonds surface-coated with photo-crosslinked lipids,” Proc. SPIE 10547, 1054704 (2018) (8pp).
H.-C. Chang*, “Diamonds in space: A brief history and recent laboratory studies,” J. Phys. Conf. Ser. 728, 062004 (2016) (6pp).
T. Zhang, H. Cui, C.-Y. Fang, J. Jo, X. Yang, H.-C. Chang, and M. L. Forrest*, “In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds,” Proc. SPIE 8815, 881504 (2013) (9pp).
Y. Kuo, T.-Y. Hsu, Y.-C. Wu, J.-H. Hsu*, and H.-C. Chang*, “Fluorescence lifetime imaging microscopy of nanodiamonds in vivo,” Proc. SPIE 8635, 863503 (2013) (7pp).
X. L. Le, A.-M. Lepagnol-Bestel, M.-P. Adam, A. Thomas, G. Dantelle, C.-C. Chang, N. Mohan, H.-C. Chang, F. Treussart*, and M. Simonneau, “Fluorescent diamond nanoparticle as a probe of intracellular traffic in primary neurons in culture,” Proc. SPIE 8232, 823203 (2012) (6pp).
C.-C. Chang, B. Zhang, C.-Y. Li, C.-C. Hsieh, G. Duclos, F. Treussart, and H.-C. Chang*, “Exploring cytoplasmic dynamics in zebrafish yolk cells by single particle tracking of fluorescent nanodiamonds,” Proc. SPIE 8272, 827205 (2012) (8pp).
N. Mohan, B. Zhang, C.-C. Chang, L. Yang, C.-S. Chen, C.-Y. Fang, H.-H. Hsieh, C.-Y. Cho, Y.-C. Wu, J.-H. Weng, B.-c. Chung, and H.-C. Chang*, “Fluorescent nanodiamond − A novel nanomaterial for in vivo applications,” MRS Proc. 1362, 25−35 (2011).

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