CV

POSITIONS AND HONOURS

        • 12/2019 up to date, Assistant Professor (Competitive tender) Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM).

        • 12/2018 to 11/2019, Researcher (Investigador doutorado). (Competitive tender) LAQV. Chemistry Department.FCT. NOVA de Lisboa, Portugal. Funded by Fundação para a Ciência e a Tecnologia with FEDER co-funding.

        • 01/2018-09/2018, Post-doctoral fellow. (Renewal) LAQV. Chemistry Department.FCT. NOVA de Lisboa, Portugal.

        • 03/2015-12/2017, Post-doctoral fellow (Competitive tender UCIBIO. Chemistry Department.FCT. NOVA de Lisboa, Portugal. Funded by Fundação para a Ciência e a Tecnologia with FEDER co-funding.

        • 01/2015-02/2015 C.E.O of the Spanish Association of Crohn’s Diseases and Ulcerative Colitis Patients Associations

        • 01/2011-12/2014, Research Associate (Competitive tender). Dep. Biochemistry and Molecular Biology. Facultad de Ciencias. Funded by the Regional Government (Junta de Extremadura) with FEDER co-funding. Universidad de Extremadura, Badajoz, Spain

        • 01/2008-06/2011, Postdoctoral Researcher (Competitive tender). Environmental and Occupational Health Department. C. for Free Radical and Antioxidant Health. University of Pittsburgh, Pittsburgh, USA. Funded by the Regional Government (Junta de Extremadura) with FEDER co-funding

        • 08/2006-10/2006, Short term scholarship at the Institute of Aging (Competitive tender). University of Florida Gainesville (USA). Funded by University of Extremadura.

        • 04/2007-06/2007, Short term scholarship at the Institute of Aging (Competitive tender). University of Florida Gainesville (USA). Funded by University of Extremadura.

        • 12/2004-11/2008, Pre-doctoral fellow (Competitive tender). Dep. Biochemistry and Molecular Biology. Facultad de Ciencias. Universidad de Extremadura, Badajoz, Spain.

        • 04/2004- 11/2004, Research technician. Dep. Biochemistry and Molecular Biology. Facultad de Ciencias. Universidad de Extremadura, Badajoz, Spain.

        • 11/2002- 08/2003, Research technician. Dep. Biochemistry and Molecular Biology. Facultad de Ciencias. Universidad de Extremadura, Badajoz, Spain.

h-index: 22 (Web of Science)

PUBLICATIONS

Sources: Number of citations (C): Scopus; Impact Factor: Web of Science

ORIGINAL PUBLICATIONS AS CORRESPONDING AUTHOR ARE INDICATED WITH AN ASTERISC *.


1) Martínez-Costa OH, Rodrigues-Miranda L, Clemente SM, Parola AJ, Basilio N, Samhan-Arias AK *. The Use of Flavylium Salts as Dynamic Inhibitor Moieties for Human Cb5R. Molecules. 2022 Dec 23;28(1):123. doi: 10.3390/molecules28010123. Q1 (Biochemistry); C:0; Impact factor 4.9.

2) Gorospe B, Moura JJG, Gutierrez-Merino C, Samhan-Arias AK*. Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol. Int J Mol Sci. 2022 Dec 2;23(23):15203. doi: 10.3390/ijms232315203.Q1 (Biochemistry); C:0; Impact factor 6.1

3) Valério GN, Gutiérrez-Merino C, Nogueira F, Moura I, Moura JJG, Samhan-Arias AK*. Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2020 1861(2):148134. doi: 10.1016/j.bbabio.2019.148134. Q1 (Biochemistry); C:0; Impact factor 4.441.

4) Samhan-Arias AK*, Cordas CM, Carepo MS, Maia LB, Gutierrez-Merino C, Moura I, Moura JJG*. Ligand accessibility to heme cytochrome b5 coordinating sphere and enzymatic activity enhancement upon tyrosine ionization. J Biol Inorg Chem. 2019 Mar 5. doi: 10.1007/s00775-019-01649-2. Q1 (Inorganic Chemistry); C:0; Impact factor 3.632.

5) Samhan-Arias AK*, Fortalezas S, Cordas CM, Moura I, Moura JJG, Gutierrez-Merino C. *(2018) Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c. Redox Biol. 15:109-114. doi: 10.1016/j.redox.2017.11.021. Q1 (Biochemistry); C:2; Impact factor 7.79. (Open access)

6) Samhan-Arias Alejandro K. *, Maia, Luisa B., Cordas Cristina M., Moura Isabel, Gutierrez-Merino Carlos, Moura José J. G *(2018) Peroxidase like activity of cytochrome b5 is triggered upon a pH dependent hemichrome formation. Biochim Biophys Acta. (Proteins and Proteomics) 866(2):373-378. doi: 10.1016/j.bbapap.2017.09.010. Q1 (Biophysics); C:1; Impact factor 2.65

7) Samhan-Arias Alejandro K. *, Almeida R.M., Cordas Cristina M., Gutierrez-Merino Carlos, Moura José J. G *(2018) Topography of cytochrome b5 reductase interacting domain with cytochrome b5 and structural consequences for its reductase upon complex formation. Biochim Biophys Acta. (Bioenergetics) 1859(2):78-87. doi: 10.1016/j.bbabio.2017.10.005 Q1 (Biochemistry); C:2; Impact factor 4.36.

8) Samhan-Arias AK*, Gutierrez-Merino C (2014) Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite. Free Radic Biol Med 73: 174-189. Q1 (Biochemistry); C:11 Impact factor 5.735.

PUBLICATIONS

9) Jairo Salazar , Joana Poejo , Ana M Mata , Alejandro K Samhan-Arias , Carlos Gutierrez-Merino. Design and Experimental Evaluation of a Peptide Antagonist against Amyloid β(1-42) Interactions with Calmodulin and Calbindin-D28k. Int J Mol Sci . 2022; 23(4):2289. doi: 10.3390/ijms23042289. Q1 (Neurochemistry); C:0 Impact factor 5.924

10) Maria João Nunes,· Gabriel N. Valério,· Alejandro Samhan‑Arias, José J.G. Moura, · Carlos Rouco, · João Paulo Sousa, · Cristina M. Cordas. Screen‑Printed Electrodes Testing for Detection of Potential Stress Biomarkers in Sweat. Electrocatalysis (2022). https://doi.org/10.1007/s12678-022-00709-7

11) Gutiérrez-Merino C, Martínez-Costa OH, Monsalve M, Samhan-Arias AK. Structural Features of Cytochrome b5-Cytochrome b5 Reductase Complex Formation and Implications for the Intramolecular Dynamics of Cytochrome b5 Reductase. Int J Mol Sci. 2021; 23(1):118. doi: 10.3390/ijms23010118. Q1 (Neurochemistry); C:0 Impact factor 5.924

12) Sofia Fortalezas, Joana Poejo, Alejandro K Samhan-Arias and Carlos Gutierrez-Merino Cholesterol-Rich Plasma Membrane Submicrodomains Can Be a Major Extramitochondrial Source of Reactive Oxygen Species in Partially Depolarized Mature Cerebellar Granule Neurons in Culture. Journal of Neurophysiology and Neurological Disorders. J Neurophysiol Neurol Disord 2019 | Vol 5: 204. DOI:10.17303/jnnd.2019.5.204 Q1 (Neurochemistry); C:0 Impact factor 4.3.

13) Mohammadyani D, Yanamala N, Samhan-Arias AK, Kapralov AA, Stepanov G, Nuar N, Planas-Iglesias J, Sanghera N, Kagan VE, Klein-Seetharaman J. 2018 Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation. Biochim Biophys Acta. (Biomembranes) 1860(5):1057-1068. doi: 10.1016/j.bbamem.2018.01.009. Q1 (Biochemistry); C:4 Impact factor 3.498.

14) Lagoa R, Samhan-Arias AK, Gutierrez-Merino C (2017) Reduction of cytochrome c and inhibition of cardiolipin-induced peroxidase activity by flavonoids: implications for their anti-apoptotic actions. Biofactors. 2017 43(3):451-468. doi: 10.1002/biof.1357. Q1 (Clinical Biochemistry); C: 2; Impact factor 3.236.

15) Samhan-Arias AK, Lopez-Sanchez C, Marques-da-Silva D, Lagoa R, Garcia-Lopez V, Garcia-Martinez V, Gutierrez-Merino C (2015) High expression of cytochrome b reductase isoform 3/cytochrome b system in the cerebellum and pyramidal neurons of adult rat brain. Brain Struct Funct. Q1 (Neurosciences); C: 0; Impact factor 4.325.

16) Samhan-Arias AK, Ji J, Demidova OM, Sparvero LJ, Feng W, Tyurin V, Tyurina YY, Epperly MW, Shvedova AA, Greenberger JS, Bayir H, Kagan VE, Amoscato AA (2012) Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. Biochim Biophys Acta 1818: 2413-2423. Q1 (Biochemistry); C: 32 Impact factor 3.389.

17) Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JP, Alexander H, Clark RS, Kochanek PM, Wipf P, Kagan VE, Bayir H (2012) Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nat Neurosci 15: 1407-1413. Q1 (Neuroscience); C: 149; Impact factor 15.252.

18) Samhan-Arias AK, Marques-da-Silva D, Yanamala, N, Gutierrez-Merino C (2012) Stimulation and clustering of cytochrome b(5) reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons. J Proteomics 75: 2934-2949. Q1 (Biochemistry); C: 13; Impact factor 3.175.

19) Kapralov AA, Yanamala N, Tyurina YY, Castro L, Samhan-Arias A, Vladimirov YA, Maeda A, Weitz AA, Peterson J, Mylnikov D, Demicheli V, Tortora V, Klein-Seetharaman J, Radi R, Kagan VE (2011) Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Biochim Biophys Acta 1808: 2147-2155. Q1 (Biochemistry); C: 45; Impact factor 3.990.

20) Samhan-Arias AK, Tyurina YY, Kagan VE (2011) Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation. J Clin Biochem Nutr 48: 91-95. Q2 (Clinical Biochemistry): C: 26; Impact factor 1.975.

21) Tyurina YY, Kisin ER, Murray A, Tyurin VA, Kapralova VI, Sparvero LJ, Amoscato AA, Samhan-Arias AK, Swedin L, Lahesmaa R, Fadeel B, Shvedova AA, Kagan VE (2011) Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. ACS Nano 5: 7342-7353. Q1 (Nanoscience and Nanotechnology); C: 51; Impact factor 11.421.

22) Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova, II, Klein-Seetharaman J, Stoyanovsky DA, Bayir H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE (2011) A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death. Nat Commun 2: 497 Q1 (Biochemistry); C: 58; Impact factor 7.396.

23) Tiago T, Marques-da-Silva D, Samhan-Arias AK, Aureliano M, Gutierrez-Merino C (2011) Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration. Cell Calcium 49: 174-183 Q2 (Molecular Biology); C: 13; Impact factor 4.311.

24) Marques-da-Silva D, Samhan-Arias AK, Tiago T, Gutierrez-Merino C (2010) L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane. J Proteomics 73: 1502-1510 Q2 (Biochemistry); C: 11; Impact factor 5.

25) Pecina P, Borisenko GG, Belikova NA, Tyurina YY, Pecinova A, Lee I, Samhan-Arias AK, Przyklenk K, Kagan VE, Huttemann M (2010) Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation. Biochemistry 49: 6705-6714. Q1 (Biochemistry); C: 40; Impact factor 3.226.

26) Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otin M, Tanokura M, Prolla TA, Leeuwenburgh C (2010) Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One 5: e11468 Q1 (Biochemistry, Genetics and Molecular Biology); C: 143; Impact factor 4.411.

27) Belikova NA, Tyurina YY, Borisenko G, Tyurin V, Samhan Arias AK, Yanamala N, Furtmuller PG, Klein-Seetharaman J, Obinger C, Kagan VE (2009) Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria. J Am Chem Soc 131: 11288-11289 Q1 (Biochemistry); C: 45; Impact factor 8.580.

28) Samhan-Arias AK, Garcia-Bereguiain MA, Martin-Romero FJ, Gutierrez-Merino C (2009) Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane. Mol Cell Neurosci 40: 14-26. Q1 (Biochemistry); C: 28; Impact factor 3.569.

29) Lagoa R, Lopez-Sanchez C, Samhan-Arias AK, Ganan CM, Garcia-Martinez V, Gutierrez-Merino C (2009) Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid. J Neurochem 111: 473-487 Q1 (Biochemistry); C: 39; Impact factor 3.999.24)

30) Samhan-Arias AK, Garcia-Bereguiain MA, Gutierrez-Merino C (2009) Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of synaptic plasma membranes. Biochem Biophys Res Commun 388: 718-722 Q1 (Biophysics); C: 17; Impact factor 2.548.

31) Garcia-Bereguiain MA+, Samhan-Arias AK+ Martin-Romero FJ, Gutierrez-Merino C (2008) Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels. Antioxid Redox Signal 10: 31-42. Q1 (Biochemistry) C: 89; Impact factor 6.190.(+) These authors contributed equally to this work.

32) Samhan-Arias AK, Duarte RO, Martin-Romero FJ, Moura JJ, Gutierrez-Merino C (2008) Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain. Arch Biochem Biophys 469: 243-254 Q1 (Biophysics); C: 10; Impact factor 2.626.

33) Lopez-Sanchez C, Martin-Romero FJ, Sun F, Luis L, Samhan-Arias AK, Garcia-Martinez V, Gutierrez-Merino C (2007) Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. Brain Res 1182: 123-137 Q1 (Neurology);C: 49; Impact factor 2.027 (cites 45).

34) Samhan-Arias AK, Garcia-Bereguiain MA, Martin-Romero FJ, Gutierrez-Merino C (2006) Regionalization of plasma membrane-bound flavoproteins of cerebellar granule neurons in culture by fluorescence energy transfer imaging. J Fluoresc 16: 393-401 Q2 (Biochemistry); C 4; Impact factor 2.610.

35) Samhan-Arias AK, Martin-Romero FJ, Gutierrez-Merino C (2004) Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Free Radic Biol Med 37: 48-61. Q1 (Biochemistry); C 77; Impact factor 5.625.

REVIEWS

36)Gutiérrez-Merino C, Martínez-Costa OH, Monsalve M, Samhan-Arias AK. Structural Features of Cytochrome b5-Cytochrome b5 Reductase Complex Formation and Implications for the Intramolecular Dynamics of Cytochrome b5 Reductase. Int J Mol Sci. 2021 Dec 23;23(1):118. doi: 10.3390/ijms23010118. Q1 (Neurochemistry); C:31 Impact factor 6.1

37) Doblado L, Lueck C, Rey C, Samhan-Arias AK, Prieto I, Stacchiotti A, Monsalve M. Mitophagy in Human Diseases. Int J Mol Sci. 2021 Apr 9;22(8):3903. doi: 10.3390/ijms22083903. Q1 (Neurochemistry); C:31 Impact factor 6.1

38) Targeting Lipid Peroxidation for Cancer Treatment. Clemente SM, Martínez-Costa OH, Monsalve M, Samhan-Arias AK. Molecules. 2020 Nov 5;25(21):5144. doi: 10.3390/molecules25215144. Q1 (Neurochemistry); C:27 Impact factor 4.5

39) Samhan-Arias AK, López-Sánchez C, Marques-da-Silva D, Lagoa R, Garcia-Lopez V, García-Martínez V and Gutierrez-Merino C (2016) Biochemical and anatomical basis of brain dysfunctions caused by cytochrome b5 reductase deficiency or dysregulation. Journal of Neurology & Neuromedicine Vol 1 Iss 6. (Open access)

40) Gutierrez-Merino C, Marques-da-Silva D, Fortalezas S, and Samhan-Arias AK (2016) The critical role of lipid rafts nanodomains in the cross-talk between calcium and reactive oxygen and nitrogen species in cerebellar granule neurons apoptosis by extracellular potassium deprivation, AIMS Molecular Science 3: 12-29. (Open access)

41) Gutierrez-Merino C, Lopez-Sanchez C, Lagoa R, Samhan-Arias AK, Bueno C, Garcia-Martinez V (2011) Neuroprotective actions of flavonoids. Curr Med Chem 18: 1195-1212 Q1 (Pharmacology); C:74; Impact factor 4.859.

42) ★ Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, Bayir H (2009) Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Adv Drug Deliv Rev 61: 1375-1385 Q1 (Pharmacology); C:82; Impact factor 11.957 .

DISSEMINATION IN MAGAZINES

1) La importancia de la microbiota para la vida. Revista Crónica 109, page 20-21.

2) Butirato, ¿Un compuesto tóxico para nuestro organismo? Revista Crónica 110, página 18-19.

BOOK CHAPTERS

1) Cristina M. Cordas, M. João Nunes, Gabriel N. Valério, Alejandro Samhan-Arias, Ludwig Krippahl, José J.G. Moura, Gilda Santos, João P. Sousa, Carlos Rouco- “Stress biomarkers detection using non-invasive methods for textiles integrated sensors development” Book Chapter in Smart Innovation, Systems and Technologies, Vol. 255, Álvaro Rocha et al: DEVELOPMENTS AND ADVANCES IN DEFENSE AND SECURITY, 978-981-16-4883-0, 510970_1_En (21), accepted (publication date predicted November 29, 2021, https://www.springer.com/us/book/9789811648830

2) Samhan-Arias AK and Gutierrez-Merino C (2014) Cytochrome b5 as a Pleiotropic Metabolic Modulator in Mammalian Cells. In: Cytochromes b and c: Biochemical Properties, Biological Functions and Electrochemical Analysis. Thom R (ed) pp 39-80. New York: Nova Science Publishers Inc.

3) Gutierrez-Merino C, Marques-da-Silva D, Fortalezas S, Samhan-Arias AK (2014) Cytosolic Calcium Homeostasis in Neurons- Control Systems, Modulation by Reactive Oxygen and Nitrogen Species, and Space and Time Fluctuations. In: Neurochemistry. Heinbockel T (ed) pp 59-110 . InTech DOI: 10.5772/57576

4) Martin-Romero FJ, Samhan-Arias AK, Garcia-Bereguiain MA, Gutierrez-Merino C (2004) Molecular biology of mammalian AFR reductases. In: Recent. Research and Developments in Molecular Biology. Pandalai SG (ed) pp 29-52. Kerala: Research Signpost.

PROCEEDINGS

1) Samhan-Arias AK, Garcia-Bereguiain MA, Gutiérrez-Merino C. (2009) Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of the synaptic plasma membrane from rat brain. In: Proceedings of the European Meeting of the Society for Free Radical Research. Caporossi D, Pigozzi F, Sabatini S (eds) pp 61-64 Bologna: Medimont SRL.

2) Lagoa R, Lopez-Sanchez C, Samhan-Arias AK, Gañán CM, Garcia-Martinez V, Gutierrez-Merino C (2009) Neuroprotective effect of kaempferol in the 3-nitropropionic acid model of Huntington’s disease. In: Proceedings of the European Meeting of the Society for Free Radical Research. Caporossi D, Pigozzi F, Sabatini S (eds) pp 85-88 Bologna: Medimont SRL.

3) Silva DM, Samhan-Arias AK, Garcia-Bereguiain MA, Tiago T, Gutiérrez-Merino C (2009) Major plasma membrane-associated redox centres co-localize with L-type calcium channels in neuronal lipid rafts microdomains. In: Proceedings of the European Meeting of the Society for Free Radical Research. Caporossi D, Pigozzi F, Sabatini S (eds) pp127-130 Bologna: Medimont SRL.

4) Tiago T, Silva DM, Samhan-Arias AK, Aureliano M, Gutiérrez-Merino C (2009) Actin cytoskeleton disruption is an early event upon exposure of cerebellar granule neurons to SIN-1-induced oxidative stress”. In: Proceedings of the European Meeting of the Society for Free Radical Research. Caporossi D, Pigozzi F, Sabatini S (eds) pp141-144 Bologna: Medimont SRL.

5) Lopez-Sanchez C, Martin-Romero FJ, Sun F, Luis L, Samhan-Arias AK, Garcia-Martinez V, Gutierrez-Merino, C (2008) Intravenous injections of kaempferol afford protection against rat brain damage induced by transient focal ischemia. In: Proceedings of the European Meeting of the Society for Free Radical Research. Grune T (ed) pp 59-62 Bologna: Medimont SRL.

6) Tiago T, Samhan-Arias AK, Gutierrez-Merino C. (2008) Cytoskeleton dynamics modulates the regionalization of plasma membrane-bound cytochrome b5 reductase in cerebellar granule neurons in culture. In: Proceedings of the European Meeting of the Society for Free Radical Research. Grune T (ed) pp 91-94 Bologna: Medimont SRL.

7) Samhan-Arias AK, Gutierrez-Merino C (2008) Plasma Membrane-bound Cytochrome b5 Reductase Is Associated with Lipid Rafts in Cerebellar Granule Neurons in Culture In: Proceedings of the European Meeting of the Society for Free Radical Research. Grune T (ed) pp 75-78 Bologna: Medimont SRL.

8) Samhan-Arias AK, Garcia-Bereguiain, MA, Gutierrez-Merino C.“Plasma membrane-bound cytochrome b5 reductase forms a large network of rédox centres that co-localizes with cholera toxin B binding sites in cerebellar granule neurons in culture (2007) In: Proceedings of the European Meeting of the Society for Free Radical Research. Laranjinha J (ed) pp147-150 Bologna: Medimont SRL.

Invited speaker in conferences

ORAL COMMUNICATIONS

1) Purified NADH-cytochrome b5 reductase is a superoxide anion-producing enzyme that is sensitive to nitric oxide and peroxynitrite. MASSTRPLAN-Advances in the Study of Lipid and Protein Oxidation: From Methods to Targets. Ghent, March 12-15th

2) Apocynin inhibits purified Cytochrome b5 reductase by competition with NADH for its active site. XIV Congress of the Spanish Biophisycal Society (SBE 2014). Alcalá de Henares, June 11-13, 2014.

3) NADH dependent ascorbate free radical recycling at the plasma membrane from terminal synapses. XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular, Zaragoza, 2005 (Spain).

4) Plasma membrane-bound cytochrome b5 reductase is associated with lipid rafts in cerebellar granule neurons in culture. SFRR (Society for Free Radical Research) European Meeting. July 2008.

+32 additional contributions as posters or oral communications in other congresses.

Posters as main contributor ( 1st author)

- Modulation of cytochrome b5 reductase activity by 5-hydroxy-1,4-naphthoquinone. Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox Homeostasis - From Signaling to Damage. Ferrara (ITALY) JUN 19-21, 2019

- Caveolin-1-rich lipid rafts are a major extramitochondrial source of reactive oxygen species in mature cerebellar granule neurons. FEBS congress 2018. Prague July 7-12th, 2018

- Structural and functional characterization of the acid and alkaline transition of cytochrome b5. Congress of the Society for Free Radical Research-Europe and International. Lisbon, Portugal 2018.

Biochemical assessment of the enzymatic superoxide anion production of the enzyme. Congress of the Society for Free Radical Research-Europe and International. Lisbon, Portugal 2018.

- Cytochrome c stimulates the superoxide anion production by cytochrome b5 reductase in neuronal synaptic plasma membrane vesicles. Congress of the Society for Free Radical Research-Europe and International. Lisbon, Portugal 2018.

- Biochemical assessment of the enzymatic superoxide anion productions by cytochrome b5 reductase. 1st Meeting of the Inorganic and Bioinorganic Chemistry Division of the Portuguese Society of Chemistry 2016.

- Apocynin inhibits purified Cytochrome b5 reductase activity by competition with NADH for its binding site on the protein. XIV Congress of the Spanish Biophysical Society (SBE 2014). Alcalá de Henares, June 11-13, 2014

- Reduction of cytochrome c by flavonoids. Congress of the Society for Free Radical Research-Europe and International. London, UK 2012

- 2D-LC-MS analysis of oxidized lipid species: application to the study of cardiolipin in apoptosis and damaged tissue. The Society of Toxicology (SOT) 51st Annual Meeting, 2012.

- Cytochrome b5/cytochrome b5 reductase up-regulation is an early event in cerebellar granule neurons apoptosis induced by extracellular potassium deprivation. Congress of the Society for Free Radical Research-Europe 2010

- Plasma membrane-bound cytochrome b5 reductase forms a large network of redox centres that co-localizes with cholera toxin B binding sites in cerebellar granule neurons in culture. Congress of the Society for Free Radical Research-Europe 2007.

- Regionalization and activities of the neuronal plasma membrane redox chain. 8th International Conference on Membrane Redox Systems, and their Role in Biological Stress and Disease. 2006

- Reciclaje dependiente de NADH del radical libre de ascorbato por la membrana plasmática de terminales sinápticas. XXVIII Congress of the Spanish Society of Biochemistry and Molecular Biology. 2005

- Regionalization of membrane-bound flavoproteins of cerebellar granule neurons in culture by fluorescence energy transfer imaging. 9th International Conference on Methods and Applications of Fluorescence (Spectroscopy, Imaging and Probes). 2005.

- Compartmentation of the plasma membrane redox chain in cerebellar granule neurons in culture. 20th Biennial Meeting of the International Society for Neurochemistry. 2005

- Biochemical characterization of the NADH oxidase activity of the synaptic plasma membrane redox chain: XIV Congress of the Portuguese Society of Biochemistry. 2004

- Ascorbate free radical recycling by the plasma membrane redox chain in synaptic terminals from rat brain. 2nd Spanish and Portuguese Congress on Free Radicals. 2004

- Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. 4th Forum of European Neuroscience. 2004

AWARDS

  • Badajoz (Spain) Ph.D. Thesis Award for the best PhD thesis in the biomedical field at the University of Extremadura, 2008.

  • Vilamoura, (Portugal) "Young Investigator Award” at the Congress of the Society for Free Radical Research-European Region SFRR-Europe, 2007.