-Meredith Grey- 

Dr Merideth grey is a excellent general surgeon, who followed in the steps of her mother Ellis Grey. Along with being a excellent general surgeon she is a great daughter, friend,  colleague, mother, and eventually wife. Her character is a damaged but strong women who sees the world in a variety  of shades of gray, which leads her to be an emotionally complexed women.

-Ellis Grey-

Dr Ellis Grey, is a great role model for her daughter. In the show Ellis, Kate Burton, at a old age develops Alzheimer's and is put into a home because Meredith isn't there to help her all the time.  Not only is she a great role model and mother to Meredith but she is the ex - wife to Thatcher Grey. Ellis Grey was a world famous surgeon before the Alzheimer's. Being honored with harper avery awards twice.

-Derek Shepherd-

Dr Derek Shepherd one of the best neurosurgeons in the world. He eventually become Chief of Surgery in Grey Sloan Memorial hospital, and an amazing husband to Meredith grey. Later on after continuing being the best to Meredith he comes a great father towards their children. His character is mainly a charming, handsome and brilliant doctor. 

-Miranda Bailey-

Dr Miranda Bailey is a straightforward, tough, smart and confident women.  Dr Bailey was the first to teach Meredith and the four other interns in the start of the show. Just like Meredith she is an amazing general surgeon. Even though Miranda Bailey's character seems to be petty sometimes she still comes in contact with her own mistakes.

-Amelia Shepherd-

Amelia Shepherds character plays as the youngest sister of Derek Shepherd. She grows to be  the Head of Neurosurgery at Grey Sloan Memorial hospital.  Her character throughout the series has the traits of individualistic, sensitive, and reflective. Eventually in the show Amelia is diagnosed with a brain tumor that was undiagnosed for a long time. Later on she over comes the tumor along with surgery. 

-Cristina Yang-

In the show Dr Cristina Yang is known as Mereideths best friend or "her person". Before leaving Grey Sloan Memorial, she was a great cardiothoracic surgeon.  Cristina Yang was never afraid of showing off her talents and was known of being a confident, strong, women whom seemed to always speak her mind. 

-Richard Webber-

Dr Richard Webber is another General Surgeon who had a relationship with Ellis Grey  in the past when they were younger, as he became like a father to Meredith Grey. His character was always a strong and wise man. Dr Richard Webber has taught Dr Miranda Bailey and many of the other interns very good on how to be a great surgeon at Grey Sloan Memorial Hospital. 

-Alex Karev-

Dr Alex Karev is a pediatric surgeon.  He is a very egotistical and vain type of person. Alex Karev is known to his good looks, which he uses to attract the females, mostly throughout the hospital. Even though he is known to his good looks, he is also aware of the problems and insecurities he has.