Publications
1. Manov I, Odeh A, Shams I (2020) Aging without inflammaging. Aging (Albany NY). Aug 27;12(16):15875-15877
1. Manov I, Odeh A, Shams I (2020) Aging without inflammaging. Aging (Albany NY). Aug 27;12(16):15875-15877
2. Odeh A, Dronina M, Domankevich V, Shams I, Manov I (2020) Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. Aging Cell. 19(1) e13045. doi: 10.1111/acel.13045
2. Odeh A, Dronina M, Domankevich V, Shams I, Manov I (2020) Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. Aging Cell. 19(1) e13045. doi: 10.1111/acel.13045
3. Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G (2019) Telomeres and Longevity: A Cause or an Effect? Int J Mol Sci. 2019 Jul 1;20(13):3233.
3. Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G (2019) Telomeres and Longevity: A Cause or an Effect? Int J Mol Sci. 2019 Jul 1;20(13):3233.
4. Altwasser R, Paz A, Korol A, Manov I, Avivi A, Shams I (2019) The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms. BMC Genomics. 2019 Jan 8;20(1):17
4. Altwasser R, Paz A, Korol A, Manov I, Avivi A, Shams I (2019) The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms. BMC Genomics. 2019 Jan 8;20(1):17
5. Mamchur A, Leman E, Salah S, Avivi A, Shams I, Manov I (2018) Adipose-Derived Stem Cells of Blind Mole Rat Spalax Exhibit Reduced Homing Ability: Molecular Mechanisms and Potential Role in Cancer Suppression. Stem Cells. 2018 36(10):1630-1642.
5. Mamchur A, Leman E, Salah S, Avivi A, Shams I, Manov I (2018) Adipose-Derived Stem Cells of Blind Mole Rat Spalax Exhibit Reduced Homing Ability: Molecular Mechanisms and Potential Role in Cancer Suppression. Stem Cells. 2018 36(10):1630-1642.
6. Domankevich V, Opatowsky Y, Malik A, Korol AB, Frenkel Z, Manov I, Avivi A, Shams I (2016) Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax. BMC Evol Biol. 2016 Sep 2;16:177
6. Domankevich V, Opatowsky Y, Malik A, Korol AB, Frenkel Z, Manov I, Avivi A, Shams I (2016) Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax. BMC Evol Biol. 2016 Sep 2;16:177
7. Iancu TC, Arad T, Shams I, Manov I (2014) Iron-rich ferritin in the hypoxia-tolerant rodent Spalax ehrenbergi: a naturally-occurring biomarker confirms the internalization and pathways of intracellular macromolecules. J Struct Biol. 187(3):254-265
7. Iancu TC, Arad T, Shams I, Manov I (2014) Iron-rich ferritin in the hypoxia-tolerant rodent Spalax ehrenbergi: a naturally-occurring biomarker confirms the internalization and pathways of intracellular macromolecules. J Struct Biol. 187(3):254-265
8. Manov I, Hirsh M, Iancu T.C, Malik A, Sotnichenko N, Band M, Avivi A, Shams I (2013) Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence. BMC Biology 11:91: 1-17
8. Manov I, Hirsh M, Iancu T.C, Malik A, Sotnichenko N, Band M, Avivi A, Shams I (2013) Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence. BMC Biology 11:91: 1-17
9. Sarig O, Goldsher D, Nousbeck J, Fuchs-Telem D, Cohen-Katsenelson K, Iancu T.C, Manov I, Saada A, Sprecher E, and Mandel H (2013). Infantile mitochondrial hepatopathy is a cardinal feature of MEGDEL syndrome (3-Methylglutaconic aciduria type IV with sensorineural deafness, encephalopathy and leigh-Like Syndrome) caused by novel mutations in SERAC1. American Journal of Medical Genetics Part A. 61(9): 2204-15
9. Sarig O, Goldsher D, Nousbeck J, Fuchs-Telem D, Cohen-Katsenelson K, Iancu T.C, Manov I, Saada A, Sprecher E, and Mandel H (2013). Infantile mitochondrial hepatopathy is a cardinal feature of MEGDEL syndrome (3-Methylglutaconic aciduria type IV with sensorineural deafness, encephalopathy and leigh-Like Syndrome) caused by novel mutations in SERAC1. American Journal of Medical Genetics Part A. 61(9): 2204-15
10. Iancu T.C, Manov I, Shaoul R, Haimi M, Lerner A. (2013) What's in a name?-"Lipolysosome": ultrastructural features of a lipid-containing organelle. Ultrastructural Pathology. 37(5):293-303
10. Iancu T.C, Manov I, Shaoul R, Haimi M, Lerner A. (2013) What's in a name?-"Lipolysosome": ultrastructural features of a lipid-containing organelle. Ultrastructural Pathology. 37(5):293-303
12. Shams I, Malik A, Manov I, Joel A, Band M, Avivi A (2013) Expression of p53-targeted DNA repair genes in the Hypoxia-tolerant subterranean mole-rat, Spalax Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat Spalax. Journal of Molecular Biology. 425(7):1111-8
12. Shams I, Malik A, Manov I, Joel A, Band M, Avivi A (2013) Expression of p53-targeted DNA repair genes in the Hypoxia-tolerant subterranean mole-rat, Spalax Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat Spalax. Journal of Molecular Biology. 425(7):1111-8
11. Pollak Y, Mechlovich D, Amit T, Bar-Am O, Manov I, Mandel S.A, Weinreb O, Meyron-Holtz E.G, Iancu T.C, Youdim M.B (2013) Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism. Journal of Neural Transmission, 120 (1):37–48
11. Pollak Y, Mechlovich D, Amit T, Bar-Am O, Manov I, Mandel S.A, Weinreb O, Meyron-Holtz E.G, Iancu T.C, Youdim M.B (2013) Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism. Journal of Neural Transmission, 120 (1):37–48
13. Klionsky D.J, Abdalla F.C, Abeliovich H, Abraham R. T,... Manov I, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8 (4):445-544 (review)
13. Klionsky D.J, Abdalla F.C, Abeliovich H, Abraham R. T,... Manov I, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8 (4):445-544 (review)
14. Asleh R, Nakhoul F.M, Miller-Lotan R, Awad H., Farbstein D, Levy N.S, Nakhoul N, Iancu T.C, Manov I, Laue M, Traber M.G, Lebold K.M, Levy A.P (2012) Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus. Free Radical Biology & Medicine 53(4):779-86
14. Asleh R, Nakhoul F.M, Miller-Lotan R, Awad H., Farbstein D, Levy N.S, Nakhoul N, Iancu T.C, Manov I, Laue M, Traber M.G, Lebold K.M, Levy A.P (2012) Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus. Free Radical Biology & Medicine 53(4):779-86
15. Manov I, Pollak Y, Broneshter R, Iancu T.C (2011) Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib – the role of extracellular signal-regulated kinase counteraction. FEBS Journal, 278(18) 3494–507
15. Manov I, Pollak Y, Broneshter R, Iancu T.C (2011) Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib – the role of extracellular signal-regulated kinase counteraction. FEBS Journal, 278(18) 3494–507
16. Iancu T.C, Manov I (2010) Ultrastructural aspects of enterocyte defects in infancy and childhood. Ultrastructural Pathology, 34(3):117-25
16. Iancu T.C, Manov I (2010) Ultrastructural aspects of enterocyte defects in infancy and childhood. Ultrastructural Pathology, 34(3):117-25
17. Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S (2008) Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. Journal of Biological Chemistry, 283(6):3316-28
17. Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S (2008) Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. Journal of Biological Chemistry, 283(6):3316-28
18. Manov I, Bashenko Y, Eliaz-Wolkowicz A, Mizrahi M, Liran O, Iancu T.C (2007) High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway. Journal of Pharmacology and Experimental Therapeutics, 322(3):1013-22.
18. Manov I, Bashenko Y, Eliaz-Wolkowicz A, Mizrahi M, Liran O, Iancu T.C (2007) High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway. Journal of Pharmacology and Experimental Therapeutics, 322(3):1013-22.
19. Hirsh M.I, Manov I, Cohen-Kaplan V, Iancu T.C (2007) Ultrastructural features of lymphocyte suppression induced by anthrax lethal toxin and treated with chloroquine. Laboratory Investigation, 87(2):182-8
19. Hirsh M.I, Manov I, Cohen-Kaplan V, Iancu T.C (2007) Ultrastructural features of lymphocyte suppression induced by anthrax lethal toxin and treated with chloroquine. Laboratory Investigation, 87(2):182-8
20. Bar A, Riskin A, Iancu T Manov I, Arad A, Shaoul R (2007) A newborn infant with protracted diarrhea and metabolic acidosis. Journal of Pediatrics, 150(2):198-201
20. Bar A, Riskin A, Iancu T Manov I, Arad A, Shaoul R (2007) A newborn infant with protracted diarrhea and metabolic acidosis. Journal of Pediatrics, 150(2):198-201
21. Iancu T.C, Mahajnah M, Manov I, Shaoul R (2007) Microvillous inclusion disease: ultrastructural variability. Ultrastructural Pathology, 31(3):173-88
21. Iancu T.C, Mahajnah M, Manov I, Shaoul R (2007) Microvillous inclusion disease: ultrastructural variability. Ultrastructural Pathology, 31(3):173-88
22. Iancu T.C, Mahajnah M, Manov I, Cherurg S, Knopf C, Mandel H (2007) The liver in congenital disorders of glycosylation: ultrastructural features. Ultrastructural Pathology, 31(3):189-97
22. Iancu T.C, Mahajnah M, Manov I, Cherurg S, Knopf C, Mandel H (2007) The liver in congenital disorders of glycosylation: ultrastructural features. Ultrastructural Pathology, 31(3):189-97
23. Manov I, Bashenko Y, Hirsh M, Iancu T.C (2006) Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic & Clinical Pharmacology & Toxicology; 99(3):213 – 24
23. Manov I, Bashenko Y, Hirsh M, Iancu T.C (2006) Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells. Basic & Clinical Pharmacology & Toxicology; 99(3):213 – 24
24. Levanon D, Manov I, Iancu T.C (2004) Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro. Ultrastructural Pathology 28(1): 3 -14
24. Levanon D, Manov I, Iancu T.C (2004) Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro. Ultrastructural Pathology 28(1): 3 -14
25. Manov I, Hirsh M, Iancu T.C. (2004) N-acetylcysteine does not protect HepG2 cells against acetaminophen- induced apoptosis. Basic & Clinical Pharmacology & Toxicology 94(5): 213-25
25. Manov I, Hirsh M, Iancu T.C. (2004) N-acetylcysteine does not protect HepG2 cells against acetaminophen- induced apoptosis. Basic & Clinical Pharmacology & Toxicology 94(5): 213-25
26. Munichor M, Cohen H, Sarid R., Manov I, and Iancu T.C (2004). Human herpesvirus 8 inclusions in primary effusion lymphoma in an HIV-seronegative male. Acta Cytologica, 48(3): 425-30
26. Munichor M, Cohen H, Sarid R., Manov I, and Iancu T.C (2004). Human herpesvirus 8 inclusions in primary effusion lymphoma in an HIV-seronegative male. Acta Cytologica, 48(3): 425-30
27. Manov I, Hirsh M, Iancu T.C (2002) Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Experimental and Toxicologic Pathology, 53(6): 489-500
27. Manov I, Hirsh M, Iancu T.C (2002) Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Experimental and Toxicologic Pathology, 53(6): 489-500
28. Mandel H, Hartman C, Berkowitz D, Elpeleg O.N, Manov I, Iancu T.C (2001) The hepatic mitochondrial DNA depletion syndrome: ultrastructural changes in liver biopsies. Hepatology; 34: 776-8
28. Mandel H, Hartman C, Berkowitz D, Elpeleg O.N, Manov I, Iancu T.C (2001) The hepatic mitochondrial DNA depletion syndrome: ultrastructural changes in liver biopsies. Hepatology; 34: 776-8
29. Manova I.P, Kolotvinov S.V, Zhilinskaia I.N, Sukhinin V.P (1990) Isolation and comparative study of highly reproductive recombinant influenza A viruses with high antibody sensitivity. Voprosi Virusologii, (Moscow), 35(6): 458-61. [Article in Russian]
29. Manova I.P, Kolotvinov S.V, Zhilinskaia I.N, Sukhinin V.P (1990) Isolation and comparative study of highly reproductive recombinant influenza A viruses with high antibody sensitivity. Voprosi Virusologii, (Moscow), 35(6): 458-61. [Article in Russian]
30. Kolotvinov S.V, Akhmetova L.I, Manova I.P, Galitarov S.S (1990) The heterogeneity of an influenza A population in its capacity to induce the synthesis of avid antibodies. Voprosi Virusologii (Moscow), 35: 367-70. [Article in Russian]
30. Kolotvinov S.V, Akhmetova L.I, Manova I.P, Galitarov S.S (1990) The heterogeneity of an influenza A population in its capacity to induce the synthesis of avid antibodies. Voprosi Virusologii (Moscow), 35: 367-70. [Article in Russian]
31. Kolotvinov S.V, Manova I.P, Podcherniaeva R.Y, Akhmetova L.I, Elkin V, Berezin V, Zhilinskaia I.N, Grigoriev V (1990) Study of influenza A virus hemagglutinin H3 avidity using monoclonal antibodies, Voprosi Virusologii (Moscow), 35(1): 13-6 [Article in Russian]
31. Kolotvinov S.V, Manova I.P, Podcherniaeva R.Y, Akhmetova L.I, Elkin V, Berezin V, Zhilinskaia I.N, Grigoriev V (1990) Study of influenza A virus hemagglutinin H3 avidity using monoclonal antibodies, Voprosi Virusologii (Moscow), 35(1): 13-6 [Article in Russian]
32. Kolotvinov S.V, Manova I.P, Galitarov S.S, and Sukhinin V.P (1987) Structural characteristics of a population of antigenic variants of the influenza A (H3N2) virus. Voprosi Virusologii (Moscow), 32(4): 409-13 [Article in Russian]
32. Kolotvinov S.V, Manova I.P, Galitarov S.S, and Sukhinin V.P (1987) Structural characteristics of a population of antigenic variants of the influenza A (H3N2) virus. Voprosi Virusologii (Moscow), 32(4): 409-13 [Article in Russian]