Laboratory for Computational Cellular Mechanobiology
Padmini Rangamani
Department of Pharmacology, School of Medicine
Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering
University of California, San Diego
Mission Statement
We are broadly interested in the interplay of cell shape, signaling, and mechanics. We use principles of mechanics coupled with signal transduction to model and identify principles underlying biological phenomena. Our interests are rather broad. Current topics of research in my lab include the biophysics of membrane curvature generation, membrane-cytoskeleton interactions, systems modeling of exercise physiology, and biophysics of neurons. Our goal is to develop a fundamental understanding of how morphology and topology regulate cellular phenomena using theoretical foundations in mechanics, mathematical representations, and coupling them to biochemical processes.
Our goal is to provide insight into complex biological systems with rigorous application of engineering and physical sciences.
Want to join us? See here for details.
Featured Publications
Reaction and transport modeling software for biological systems
E. A. Francis*, J. G. Laughlin*, J. S. Dokken, H. N. T. Finsberg, C. T. Lee, M. E. Rognes$, and P. Rangamani$: Spatial modeling algorithms for reactions and transport (SMART) in biological cells (biorxiv link). Accepted Nat. Comp. Sci.
1. L. Qiao, M. Getz, B. Gross, B. Tenner, J. Zhang$, and P. Rangamani$: Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop (bioRxiv link). Accepted PLoS Comp Biol
2. L. Qiao*, A. Khalilimeybodi*, N. Linden-Santangeli*, and P. Rangamani$: The evolution of systems biology and systems medicine: From mechanistic models to uncertainty quantification (arXiv link). Accepted Annual Reviews of Biomedical Engineering
3. B. Debnath, B. N. Narasimhan, S. I. Fraley$, and P. Rangamani$: Modeling collagen fibril degradation as a function of matrix microarchitecture. (bioRxiv link) Accepted Soft Matter
