RNA targeting: First, the caRNA can target specific genomic sequences, which could be mediated by tethering molecules.

RNA confinement: Second, the spatial proximity of the genomic sequences in 3D space could bring the nascent transcripts of one gene to the genomic sequence of another gene.

Thus, the RNA-poise model can be regarded as a union of two submodels, depending on the process of RNA–DNA interaction. One submodel (targeting-poise model) could create fusion transcripts only by transsplicing.The other submodel(confinement-poise model)could create fusion transcripts by either transsplicing or creation of fusion genes.