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Dr En-Pei Isabel Chiang received her PhD in Biochemical & Molecular Nutrition from Tufts University in 2000 (mentor: Jacob Selhub), and post-doctoral training at UC Berkeley in biochemistry and metabolism (mentor: Barry Shane) in 2003. Chiang initiated her career in 2003 as a tenure-track Assistant Professor, rose through the ranks to Associate Professor in 2007, and Professor in 2011. Currently Chiang is a life-time distinguished professor at National Chung Hsing University, Taiwan. Chiang works in the areas of folate mediated one carbon metabolic kinetics, nutrient-genome interactions, as well as fundamental aspects of nutrient metabolism and regulation. The current focus of her research also involves the mechanisms by which inflammatory mediators and anti-inflammatory therapies alter vitamin B6 synthesis and utilization. Her research program has been well funded through competitive extramural research grants since the establishment of her independent research career in 2003 and has published her research works in major nutrition, biochemistry, and medical journals. Up to now her publications have been cited over 1500 times (on average each cited >30); and has given/chaired >50 presentations at the FASEB, Asian Nutrition Congress, International Union of Nutritional Sciences, International Conference on Food Factors, International Symposium on Biocatalysis and Agricultural Biotechnology, and other major international conferences. She has received honors from American Society of Nutrition (E.L.R. Stokstad Award), American Association of Cancer Research (Scholar in Training Award); Arthritis Foundation (Doctoral Dissertation Award), Academia Sinica of Taiwan (Shang-Fa Yang Young Scholar Award), Ministry of Science & Technology of Taiwan (Future Technology Award; Outstanding Young Scholar Grant), Taiwan Food Science & Technology Society (Outstanding Young Scholar); Taiwan Nutrition Society (Prof Chen Award for Young Scholar; Outstanding Researcher) and many others.
chiangisabel@nchu.edu.tw +886-4-2285-3049
https://sites.google.com/email.nchu.edu.tw/chiang-lab-2021/pi?authuser=0
2023
The Sizes and Composition of HDL-Cholesterol Are Significantly Associated with Inflammation in Rheumatoid Arthritis Patients
Chang CK, Chiang EP, Chang KH, Tang KT, Chen PK, Yip HT, Chen CH, Chen DY
Int J Mol Sci (IF 6.208) 2023, 24(13) 10645. 2023 Jun. PMID- Full article 全文
Gender difference in MAT2A protein translocation and its prognostic relevance for female liver hepatocellular carcinoma
Chu PY, Chou DA, Chen PM, and Chiang EP* (Corresponding author).
Int J Mol Sci (IF 6.208) 2023, 24(10), 9103. 2023 May. PMID- Full article 全文
Novel probiotic formula for enhancing vitamin b6 content in vivo and use thereof as a vitamin B6 promoter . 技術轉移: 食生系蔣恩沛教授「提升體內維生素B6含量之新穎益生菌配方及其作為維生素B6促進劑之用途」 Technology Transfer 2023 May.
Docosahexaenoic Acid Alleviates Trimethylamine-N-oxide-mediated Impairment of Neovascularization in Human Endothelial Progenitor Cells
Syu JN , Lin HY, Huang TY , Lee DY, Chiang EP, Tang FY.
Nutrients (IF 6.706) 15(9), 2190; Full article
Novel probiotic formula for enhancing vitamin b6 content in vivo and use thereof as a vitamin B6 promoter 提升體內維生素B6含量之新穎益生菌配方及其作為維生素B6促進劑之用途 蔣恩沛 EP Chiang*; 梁孟群; MC Liang; CC Huang; 黃羽萱 YH Huang; 曾子芸 ZY Zeng; 彭建豪 JH Peng; DY Wu.
ROC Patent 中華民國專利 I688767 (2023 May) (2023/0?/??-20??/??/??) 領證中
Endophytic Biostimulants for Smart Agriculture: Burkholderia seminalis 869T2 Benefits Heading Leafy Vegetables In-Field Management in Taiwan
Hung SHW, Huang TC, Lai YC, Wu IC, Liu CH, Huarng YF, Hwang HH, Chiang EP, Kuo CH, Huang CC.
Microorganisms 2023, 13, 967. https://doi.org/10.3390/agronomy13040967
Conversion of Escherichia coli into Mixotrophic CO2 Assimilation with Malate and Hydrogen Based on Recombinant Expression of 2-Oxoglutarate:Ferredoxin Oxidoreductase Using Adaptive Laboratory Evolution
Cheng YC, Huang WH, Lo SC; Huang E, Chiang EP, Huang CC, Yang YT. Microorganisms 2023, 11(2), 253. Full article
Association of Metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese
Chen RF, Chen PM, Pan CS, Huang CC, Chiang EP* (Corresponding author).
Scientific Reports. 13, Article number: 1292 (2023) Full article
2022
N-3 polyunsaturated fatty acids block the trimethylamine-N-oxide- ACE2- TMPRSS2 cascade to inhibit the infection of human endothelial progenitor cells by SARS-CoV-2 (Nov, 2022)
Chiang EP*; Syu JN; Hung HC; Rodriguez RL; Wang WJ; Chiang ER; Chiu SC; Chao CY; Tang FY
J Nutr Biochem. (IF=6.117) 2022 Nov;109:109102. doi: 10.1016/j.jnutbio.2022.109102. Epub 2022 Jul 8.
Full article 全文 PMID: 35817244
Lipid metabolomic signature might predict subclinical atherosclerosis in patients with active rheumatoid arthritis
Chang CK, Chang, CH, Cheng WC, Chen PK, Chiang EP, Chang SH, Li YC, Chen CH, Chen DY. 2022 Oct 4. doi: 10.55563/clinexprheumatol/int08c. (Oct 2022)
(IF=4.862). PMID: 36200949 摘要
Ketogenic Diet Consumption Inhibited Mitochondrial One Carbon Metabolism. (IF 6.208)
Hsu F-Y, Liou J-Y, Tang FY, Sou NL, Peng JH, Chiang EP* (Corresponding author)
Int J Mol Sci (IF 6.208) 2022 Mar 26, 23(7), 3650 (Mar 2022)
Full article 全文 PMID: 35409009
Non-invasive analytic method for simultaneously quantifying and tracing metabolic fluxes in fatty acid syntheses in vivo by GC-CI/MS system 利用GC-CI/MS平台非侵入性同步定量及追蹤體內脂肪酸合成碳源路徑之分析方法 蔣恩沛 Chiang EnPei*; 蘇雅麗 Sou, Nga Lai; 黃羽萱 Yu-Hsuan Huang, 陳佳郁 Chia-Yu Chen, 周奕秀 Yi-Hsao Chow; Chieh Chen Huang. ROC Patent I759783 中華民國專利 (2022/04/01-2040/06/30)
Downregulation of methionine cycle gene MAT1A and GNMT enriches protein-associated translation process and worsens hepatocellular carcinoma prognosis. (IF 6.208)
Chen PM, Tsai CH, Huang CC, Hwang HH, Li JR, Liu CC, Ko HA, and Chiang EP* (Corresponding author)
Int J Mol Sci (IF 6.208) 2022 Jan 1;23(1):481.
full article 全文 PMID: 35008908
2021
Docosahexaenoic acid inhibits cell proliferation through a suppression of c-Myc protein in pancreatic ductal adenocarcinoma cells. (IF 7.675)
Syu JN, Lee DY, Hung HC, Li CY, Lin HY, Chiang EP, Chen YH, Huang SM,Tang FY.*
Antioxidants (IF 7.675) 2021 Oct 28;10(11):1721.
Full article 全文 PMID: 34829591
Tryptophan plays an important role in yeast’s tolerance to isobutanol. (IF 7.670)
Liu HL, Wang C, Chiang EP, Huang CC*, Li WH*.
Biotechnology for Biofuels (IF 7.670) 14: 200 (2021) (Sep, 2021)
Full article 全文 PMID: 34645498
MTHFR knockdown assists cell defense against folate depletion induced chromosome segregation and uracil misincorporation in the DNA. (IF 6.208)
Wu MT, Yeh WT, Wang YC, Chen PM, Liu JY, Tai CK, Tang FY, Li JR, Liu CC, Chiang EP* (Corresponding author)
Int J Mol Sci (IF 6.208) 2021 Aug 30;22(17):9392. (Aug, 2021).
PMID: 34502300 Full article 全文
A plant endophytic bacterium, Burkholderia seminalis strain 869T2, promotes plant growth in Arabidopsis, pai-tsai, Chinese amaranth, lettuces and other vegetables. (IF 4.926)
Hwang HH*, Chien PR, Huang FC, Hung SH, Kuo CH, Deng WL, Chiang EP, Huang CC*.
Microorganisms (IF 4.926) 2021, 9(8), 1703. (Aug, 2021)
Full article 全文 【學術亮點】植物內生菌Burkholderia seminalis 869T2可促進阿拉伯芥,青江菜,小白菜,萵苣,莧菜等作物生長
Growth enhancement facilitated by gaseous CO2 through heterologous expression of reductive tricarboxylic acid cycle genes in Escherichia coli. (IF 5.123)
Lo SC, Chiang EP, Yang YT, Li SY, Peng JH, Tsai SY, Wu DY, Yu CH, Huang CH, Su TT, Tsuge K, Huang CC.*
Fermentation (IF 5.123) 2021, 7(2), 98. (Jun, 2021).
Full article 全文
MAT2A localization and its independently prognostic relevance in breast cancer patients. (IF 6.208)
Chu PY, Wu HJ, Wang SM, Chen PM, Tang FY, Chiang EP*(Corresponding author).
Int J Mol Sci (IF 6.208) 22(10), 5382; (May, 2021).
https://www.mdpi.com/1117078 Full article 全文 metrics PMID:34065390
Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo (IF 6.208)
Sou NL, Huang YH, Chen DY, Chen YM, Tang FY, Ko HA, Fan YH, Lin YY, et al Chiang EP*(Corresponding author).
Int J Mol Sci (IF 6.208), 22(3), 1350 (Jan, 2021)
PMID: 33572934 full article 全文 metrics 【學術亮點】亞葉酸補充改善甲氨蝶呤引起的線粒體甲酸消耗
Treatment of 13-cis Retinoic Acid and 1,25-dihydroxyvitamin D3 Inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells
Chiang, EP* Cheng YH*, Syu JN*, Chao CY, Lin HY, Lin CC, Yang MD, Tsai SY, and Tang FY.
PLoS One. 2021 Mar 17;16(3):e0247550. (Mar, 2021)
PMID: 33730072 full article 全文
2020
Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo. (IF 6.208)
Int J Mol Sci (IF 6.208), 21(22), 8808. (2020, Dec).
Tan YL, Sou NL, Tang FY, Ko HA, Yeh WT, Peng JH, Chiang, EP*(Corresponding author).
PMID: 33233834 full article 全文 metrics
Docosahexaenoic acid inhibits the proliferation of Kras/TP53 double mutant pancreatic ductal adenocarcinoma cells through modulation of glutathione level and suppression of nucleotide synthesis.
Chiang, EP*, Hung WC*, Lee DY*, Syu JN, Chao CY, Yang MD, Tsai SY, Tang FY.
PLoS One. 2020;15(11):e0241186. doi: 10.1371/journal.pone.0241186. eCollection 2020. (2020 Nov)
PMID: 33137095
Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients (IF 4.964)
Chu PY; Wang SM; Chen PM; Tang FY; Chiang EPI*(Corresponding author).
J Clin Med. (IF 4.964) 2020 ;9(10):3153. doi: 10.3390/jcm9103153. (2020 Sep)
PMID: 33003428 Research Hightlight metrics 【學術亮點】MTDH 和 IL-10 的表達是 ER 陰性或 PR 陰性乳腺癌患者預後不良的獨立預測因子
Decyl caffeic acid inhibits the proliferation of colorectal cancer cells in an autophagy-dependent manner in vitro and in vivo
Chen C, Kuo YH, Lin CC, Chao CY, Pai MH, Chiang EPI, Tang FY.
PLoS One 2020 May 13;15(5):e0232832. doi: 10.1371/journal.pone.0232832. eCollection 2020. (2020 May)
PMID:32401800
Metabolic Pathways Enhancement Confers Poor Prognosis in P53 Exon Mutant Hepatocellular Carcinoma.
Chen PM, Li JR, Liu CC, Tang FY, Chiang EI*(Corresponding author).
Cancer Inform. 2020 Jan 7;19:1176935119899913. doi: 10.1177/1176935119899913. eCollection 2020.
PMID: 31933519
LCMS PLATFORM FOR TRACING SAM SYNTHESIS PATHWAY AND USE THEREOF IN DRUG DEVELOPMENT 追蹤Ｓ-腺苷甲硫胺酸合成路徑之液相層析質譜平台及其於藥物開發之應用 蔣恩沛 CHIANG, EN PEI ISABEL*;蘇雅麗 SOU, NGA LAI;林宜瑩 LIN, YI YING;范翊暄 FAN, YI HSUAN;張怡璟 CHING, CHANG YI; HUANG, CHIEH CHEN
ROC Patent 中華民國專利 I688767 (2020 Mar) (2020/03/21-2038/12/05)
2019
MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S-adenosylmethionine and de novo purine synthesis. (IF=6.876)
Wang YC, Wu MT, Tang FY, Chen DY, Ko HA, Shane B, Huang WN, Chiang EP*(Corresponding author).
Clin Sci (Lond). 2019 Jan 25;133(2):253-267. doi: 10.1042/CS20180932. 2019 Jan (IF=6.876)
PMID: 30606816 【學術亮點】MTHFR C677T基因多態性透過抑制S-腺苷甲硫氨酸和嘌呤合成提高疾病修飾抗風濕病藥物敏感性
FATTY ACID COMPOSITION OF OMEGA-3 FA AND OMEGA-6 FA AND USE THEREOF IN PROMOTING LEVEL OF ENDOGENOUS BIOACTIVE B6 VITAMIN. 含 Omega-3 脂肪酸Omega-6脂肪酸之組成物及其用於增進內源性活化型維生素Ｂ６合成之用途 (公告日 2019 Feb)
ROC Patent 中華民國專利 I650123 (2019/02/11-2037/08/30)
En-Pei Chiang*, Shyi-Dong Yeh , Feng-Yao Tang, Yan-Shan Wu, San-San Wong, Yi-Chun Chen
2017
N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo. (IF=6.117)
Chiu SC, Chao CY, Chiang EI, Syu JN, Rodriguez RL, Tang FY.
J Nutr Biochem. (IF=6.117) 2017 Jan 28;42:172-181. doi: 10.1016/j.jnutbio.2017.01.009.
Impact of diet-derived signaling molecules on human cognition : exploring thr food-brain axis .
Rodriguez RL, Albeck JG, Taha AY, Ori-Mckenney KM, Recanzone GH, Stradleigh TW, Hernandez BC, Tang FV, Chiang EI*(equal corresponding author).,Cruz-Orengo L. (IF=7.00)
NPJ Sci Food. (IF=7.00) 2017 Oct 30;1:2. doi: 10.1038/s41538-017-0002-4. eCollection 2017.
PMID: 31304244
S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. (IF=4.139)
Syu JN, Yang MD, Tsai SY, Chiang EI , Chiu SC, Chao CY, Rodriguez RL, Tang FY.
Cell Transplant. (IF=4.139) 2017 Oct;26(10):1636-1647. doi: 10.1177/0963689717724792.
PMID: 29251114
Dual inhibition of key proliferation signaling pathways in triple negative breast cancer cells by a novel derivative of Taiwanin A. (IF=6.009)
Chiang EI*, Kuo YH*, Chao CY*, Rodriguez RL, Chou PY, Tsai SY, Pai MH, Tang FY.
Mol Cancer Ther. 2016 Dec 12. pii: molcanther.0011.2016. (2017 Mar)(IF=6.009)
NEW USE OF LYCOPENE AND PREPARATION OF LYCOPENE BASED ON THE SAME 茄紅素之新用途及基於此新用途之製劑 蔣恩沛 CHIANG, EN PEI;葉錫東 YEH, SHYI DONG;唐烽堯 TANG, FENG YAO;黃珊珊 WONG, SAN-SAN;吳晏珊 WU, YAN SHAN;陳怡均 CHEN, YI CHUN
ROC Patent 中華民國專利 (公告日 2017/12/11) I607750 (2017/12/11-2035/10/06)
2015
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Wang YC, Wu MT, Lin YJ, Tang FY, Ko HA, Chiang EP*(Corresponding author).
J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S148-50. doi: 10.3177/jnsv.61.S148.
2014
Lower serum folate is associated with development and invasiveness of gastric cancer. (IF 5.374)
Lee TY, Chiang EP*(equal corresponding author)., Shih YT, Lane HY, Lin JT, Wu CY.
World J Gastroenterol. (IF 5.374) 2014 Aug 28;20(32):11313-20. doi: 10.3748/wjg.v20.i32.11313.
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways.
Chiang EP*, Tsai SY, Kuo YH, Pai MH, Chiu HL, Rodriguez RL, Tang FY.
PLoS One. 2014 Jun 24;9(6):e99631. doi: 10.1371/journal.pone.0099631.
Eicosapentaenoic acid induces neovasculogenesis in human endothelial progenitor cells by modulating c-kit protein and PI3-K/Akt/eNOS signaling pathways. (IF=6.117)
Chiu SC, Chiang EP*, Tsai SY, Wang FY, Pai MH, Syu JN, Cheng CC, Rodriguez RL, Tang FY.
J Nutr Biochem. (IF=6.117) 2014 Sep;25(9):934-45. doi: 10.1016/j.jnutbio.2014.04.007.
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage. (IF=7.316)
Wang YC, Lin WL, Lin YJ, Tang FY, Chen YM, Chiang EP*(Corresponding author).
Int J Cancer. 2014 Feb 15;134(4):799-810. doi: 10.1002/ijc.28420. (IF=7.316)
2013
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism. (IF=8.472)
Chang HY, Tang FY, Chen DY, Chih HM, Huang ST, Cheng HD, Lan JL, Chiang EP*(Corresponding author).
Am J Clin Nutr. 2013 Dec;98(6):1440-9. doi: 10.3945/ajcn.113.064477. (IF=8.472)
Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways. (IF 5.895)
Chiang EP*, Chiu SC, Pai MH, Wang YC, Wang FY, Kuo YH, Tang FY.
J Agric Food Chem. (IF 5.895) 2013 May 22;61(20):4839-49. doi: 10.1021/jf304951p.
2012
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. (IF 6.376)
Wang YC and Chiang EP* (*Corresponding author).
Molecular Medicine (IF 6.376) NSC97-2320-B-005-008-MY3 and NSC100-2628-B-005-002-MY4
Serine Hydroxymethyltransferase anchors the de novo thymidylate synthesis pathway to the nuclear lamina for DNA synthesis. (IF 5.486, Biochemistry & Molecular Biology)
Anderson D, Woeller C, Chiang EP, Shane B, Stover PJ.
Journal of Biological Chemistry (IF 5.486, Biochemistry & Molecular Biology), in Biochemistry & Molecular Biology 0
Consumption of high-fat diet induces tumor progression and epithelialmesenchymal transition of colorectal cancer in a mouse xenograft model. (IF=6.117)
Tang FY, Pai MH, Chiang EP.
Journal of Nutritional Biochemistry (IF=6.117) 2012 Jan
2011
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation. . (IF 6.376)
Wang YC, Chen YM, Lin YJ, Liu SP, Chiang EP* (*Corresponding author).
Molecular Medicine. (IF 6.376) Medicine Research & Experimental Top 10%). NSC97-2320-B-005-008-MY3
Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expressions in patients with and without methotrexate treatment (IF 11.15
Chen DR, Chih HM, Lan JL, Chang HY, Chen WW, Chiang EP*(Corresponding author).
BMC Medicine. 2011 Jan 13;9:4. (IF 11.15)
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
Wang YC, Tang FY, Chen SY, Chen YM, Chiang EP* (*Corresponding author).
Journal of Nutrition 2011 May;141(5):777-82. (IF 4.687 Nutrition & Dietetic). NSC97-2320-B-005-008-MY3
Long-term prednisolone treatments increase bioactive vitamin B6 synthesis in vivo. (IF 4.402)
Chang HY, Tzen JT, Lin SJ, Wu, YT, Chiang EP*(Corresponding author).
Journal of Pharmacology & Experimental Therapeutics 2011 Apr;337(1):102-9. (IF 4.402 Pharmacology & Pharmacy) NSC97-2320-B-005-008-MY3 andDOH 97-TD-D-113-97011
Low-dose methotrexate treatment is associated with increased total cholesterol and HDL-cholesterol in blood: a pilot study
Chih HM, Chang HY, Chen WW, Chen DR, Lan JL, Chiang EP*(Corresponding author).
Nutrition Science Journal 2010.Dec. DOH 97-TD-D-113-97011
S-Allylcysteine inhibits tumor progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer.
Pai MH, Kuo YH, Chiang EP, Tang FY.
British Journal of Nutrition. 2011 Oct 20:1-11.
2010
Isatis indigotica induces hepatocellular cancer cell death via caspase- independent, apoptosis inducing factor translocation apoptotic pathway in vitro and in vivo.
Chuang YC, Tang FY, Liao JW, Chuang CH, Jong TT, Chen SS, Tsai CH, Chiang EP* (Corresponding author).
Integrative Cancer Therapy. (2011 Mar).
PMID:21382959
Consumption of S-allylcysteine inhibits the growth of human non-small cell lung carcinoma in a mouse xenograft model. (IF 5.279)
Tang FY*, Chiang EP* (corresponding author), and Pai MH.
Journal of Agricultural and Food Chemistry (IF 5.279) (Agriculture Multidisciplinary 4.5%, Top 2)
PMID:20866043
2009
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation.
Chiang EP*(Corresponding author), Wang YC, Chen WW, Tang FY.
Journal of Clinical Endocrinology & Metabolism 2009 Mar;94(3):1017-25. (2010 SCI IF 6.495 Endocrinology & Metabolism 11%) supported by NSC97-2320-B-005-008-MY3) (cited by Cell Metabolism).
PMID:19088160
S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer (6.048)
Tang FY, Chiang EP and Chung JG, Lee HZ, Hsu CY.
Journal of Nutritional Biochemistry (6.048) 2009 Dec;20 (12) : 1013-20.
PMID:19088160
The methylenetetrahydrofolate reductase C677T mutation induces cell specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification. (IF=7.396)
Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang YJ, Cho RC, Yates Z, Lucock M, Chiang EP, Austin RC, Choi SW, Laird PW, Kim YI.
International Journal of Cancer. 2009 May 1;124(9):1999-2005. (IF=7.396).
PMID:19123462
2007
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate dependent remethylation in human transformed lymphoblasts. (IF 12.883)
Chiang EP*(Corresponding author), Wang YC, Tang FY.
Leukemia (IF 12.883) 2007 Apr;21(4):651-8.
PMID:17301815
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver (IF 17.298)
Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Hwang SF, Chen YM.
Hepatology (IF 17.298 Gastroenterology & Hepatology) 2007 Oct 15;46(5):1413-1425 NSC95-3112-B-010-010 (PMID:17937387)
Resveratrol inhibits heregulin-beta1 mediated matrix metalloproteinase 9 expression and cell invasion in human breast cancer cells. (IF=6.117)
Tang FY, Chiang EP.
Journal of Nutritional Biochemistry . 2008 19: 287-294. (IF=6.117)
PMID:17651959
Elevated plasma osteopontin associated with gastric cancer development, invasion and survival. (IF 31.793)
Wu CY, Wu MS, Chiang EP, Wu, CC, Chen YJ, Chen CJ, Chi NH, Chen GH, Lin JT.
Gut 2007 Jun;56(6):782-9. (IF 31.793)
PMID:17148500)
Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution. (IF 13.801)
Wu CY, Wu MS, Chiang EP, Chen YJ, Chen CJ, Chi NH, Shih YT, Chen GH, Lin JT.
Clinical Cancer Research 2007 Apr 1;13(7):2054-60 (IF 13.801)
PMID:17404086
Green tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells (6.117)
Tang FY, Chiang EP, Shih CJ
Journal of Nutritional Biochemistry 18(6) 391-399 (6.117)
PMID:17049832
2006
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase.
Anguera MC, Field MS, Perry C, Ghandour H, Chiang EP, Selhub J, Shane B, Stover PJ. (IF 5.486)
Journal of Biological Chemistry (IF 5.486, Biochemistry & Molecular Biology) 2006 Jul.7;281(27):18335-42. (cited by Science in 2010)
PMID:16627483
2005
Cell and stage of transformation -specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model
Stempak JM, Sohn KJ, Chiang EP, Shane B, Kim YI.
Carcinogenesis (IF=5.1) 2005 May;26(5):981-90. Supported in part by NSC-93-2320- B-005-006
PMID:15695236
Chiang EP* (Corresponding author), Smith DE, Selhub J, Dallal G, Wang YC, and Roubenoff R. Inflammation causes tissue specific depletion of vitamin B6. (IF 5.606)
Arthritis Research & Therapy (IF 5.606) 2005 Sep 7(6)R1254-1262 Supported in part by NSC 94-2320-B005-009 Highlighted article
PMID:16277678
Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. (IF 5.606)
Chiang EP*(Corresponding author), Selhub J, Bagley P, Dallal G, and Roubenoff R.
Arthritis Research & Therapy (IF 5.606) 2005 Oct 7:1404-1411. NSC 94-2320-B005-009 Highlighted article
PMID:16277693
2003
Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. IF 5.928
Chiang EP*(Corresponding author), Bagley P, Selhub J, Nadeau M, and Roubenoff R.
American Journal of Medicine (SCI 2010 IF 5.928 Medicine, General & Internal Top 9%)
PMID:12681455
Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
Chiang EP*(Corresponding author), Roubenoff R, Selhub J, Bagley PJ.
Journal of Nutrition 133:1056-1059 (IF 4.798 Nutrition & Dietetic)
PMID:12672918
2002
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate–dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. (IF 5.486)
Herbig K, Chiang E-P, Lee LR, Hills J, Shane B and Stover PJ.
Journal of Biological Chemistry (IF 5.486, Biochemistry & Molecular Biology) 2002 Oct. 277 (41):38381-9.
PMID:12161434 (cited>200) 全文