We are developing a capacity to link molecular sequence evolution to geochemical signatures of this evolution which may be found in the form of non-equilibrium isotope distributions in ancient sediments. If we're successful, we can learn about trajectories of sequence evolution through time, and the time frames of enzyme molecular evolution on the time scale of the geochemically available Earth. We can learn about enzyme mechanisms too.

Isotope ratio mass spectrometry ・protein purification ・ enzyme assay ・molecular ancestral state reconstruction ・